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Results for "

GlyRs

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aminoacyl-tRNA Synthetase (1) Apoptosis (4) Autophagy (4) Bacterial (1) Endogenous Metabolite (6) GABA Receptor (2) GlyT (1) Isotope-Labeled Compounds (4) Microtubule/Tubulin (4) nAChR (1) NOD-like Receptor (NLR) (4) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (5) Infection (1) Neurological Disease (12)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108940

GlyRS-IN-1	Aminoacyl-tRNA Synthetase Bacterial	Infection Cancer
GlyRS-IN-1 is a glycyl-tRNA synthase (GlyRS) inhibitor extracted from patent WO 2017066459 A1. GlyRS-IN-1 can also inhibit the growth of bacteria .

HY-41700

D-Alanine (R)-Alanine; Ba 2776; D-α-Alanine	Endogenous Metabolite	Neurological Disease
D-Alanine is a weak *GlyR* (inhibitory glycine receptor) and PMBA agonist, with an EC₅₀ of 9 mM for GlyR .

HY-161246

uPSEM792	Others	Neurological Disease
uPSEM792 is a pharmacologically selective effector molecules (PSEM) agonist for PSAM ⁴-GlyR, with an affinity of K_i of 0.7 nM. uPSEM792 is a substrate for efflux transporters in brains of wild type and dual P-gp and BCRP knockout mice. uPSEM7952 is a possible lead for developing the PET radioligand for PSAM ⁴-GlyR .

HY-41700S1

D-Alanine-d4 (R)-Alanine-d₄; Ba 2776-d₄; D-α-Alanine-d₄	Endogenous Metabolite	Others
D-Alanine-d₄ is the deuterium labeled D-Alanine. D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR.

HY-41700S

D-Alanine-d3 (R)-Alanine-d₃; Ba 2776-d₃; D-α-Alanine-d₃	Isotope-Labeled Compounds Endogenous Metabolite	Others
D-Alanine-d₃ is the deuterium labeled D-Alanine. D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR.

HY-41700S3

D-Alanine-d7 (R)-Alanine-d₇; Ba 2776-d₇; D-α-Alanine-d₇	Endogenous Metabolite	Neurological Disease
D-Alanine-d₇ is the deuterium labeled D-Alanine. D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR.

HY-107782

Picrotin	GABA Receptor	Neurological Disease
Picrotin is an active compound, also is one of the composition of picrotoxin (an antagonist of GABAA receptors (GABAARs) and glycine receptors (GlyRs)). Picrotin has sensitivity for *GlyRs* with IC₅₀ values range from 5.2 μM to 106 μM. Picrotin can be used for the research of neurotransmission .

HY-161182

uPSEM792 hydrochloride	Others	Others
uPSEM792 hydrochloride is a PSAM ⁴-GlyR agonist .

HY-41700S2

D-Alanine-d1 (R)-Alanine-d₁; Ba 2776-d₁; D-α-Alanine-d₁	Isotope-Labeled Compounds Endogenous Metabolite	Neurological Disease
D-Alanine-d is the deuterium labeled D-Alanine. D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR[1].

HY-RS05512

GLYR1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GLYR1 Human Pre-designed siRNA Set A contains three designed siRNAs for GLYR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GLYR1 Human Pre-designed siRNA Set A GLYR1 Human Pre-designed siRNA Set A

HY-16569S

Colchicine-d6	Isotope-Labeled Compounds Microtubule/Tubulin NOD-like Receptor (NLR) Autophagy Apoptosis	Cancer
Colchicine-d₆ is the deuterium labeled Colchicine. Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM[1][2][3]. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs)[4].

HY-16569S1

Colchicine-d3	Isotope-Labeled Compounds Microtubule/Tubulin NOD-like Receptor (NLR) Autophagy Apoptosis	Cancer
Colchicine-d₃ is the deuterium labeled Colchicine. Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM[1][2][3]. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs)[4].

HY-16569

Colchicine 30+ Cited Publications	Microtubule/Tubulin NOD-like Receptor (NLR) Autophagy Apoptosis	Cancer
Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research .

HY-107782R

Picrotin (Standard)	GABA Receptor	Neurological Disease
Picrotin (Standard) is the analytical standard of Picrotin. This product is intended for research and analytical applications. Picrotin is an active compound, also is one of the composition of picrotoxin (an antagonist of GABAA receptors (GABAARs) and glycine receptors (GlyRs)). Picrotin has sensitivity for GlyRs with IC₅₀ values range from 5.2 μM to 106 μM. Picrotin can be used for the research of neurotransmission .

HY-16569R

Colchicine (Standard)	Microtubule/Tubulin NOD-like Receptor (NLR) Autophagy Apoptosis	Cancer
Colchicine (Standard) is the analytical standard of Colchicine. This product is intended for research and analytical applications. Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research .

HY-136232

PSEM 308 hydrochloride	Others	Neurological Disease
PSEM 308 hydrochloride is a pharmacologically selective actuator module (PSAM) agonist. PSEM 308 Activates PSAML141F-GlyR chimeric ion channels .

HY-147367

AM-1488	Others	Neurological Disease
AM-1488 is a potent, orally active glycine receptor (GlyR) potentiator (hGlyRα3 EC₅₀=0.45 μM) .

HY-117547

Licostinel ACEA-1021	Others	Neurological Disease
Licostinel (ACEA-1021) is a glycine receptor antagonist (IC₅₀: 59 nM). Licostinel has neuroprotective activity .

HY-124550

Sarcophine (+)-Sarcophine	Endogenous Metabolite	Neurological Disease
Sarcophine ((+)-Sarcophine) is a potent glycine receptor (GlyR) inhibitor with an IC₅₀ value of 3.9 μM. Sarcophine is a nature product that could be isolated form the Red Sea soft coral Sarcophyton glaucum .

HY-112217A

PSEM 89S TFA	nAChR	Neurological Disease
PSEM 89S TFA is a selective and brain penetrant agonists for the resulting ion channels. PSEM 89S TFA is orthogonally selective for Q79G and L141F, respectively .

HY-107526

(Rac)-ALX 5407 (Rac)-NFPS	GlyT	Neurological Disease
NFPS is a selective, non-competitive glycine transporter-1 (GlyT1) inhibitor with IC₅₀s of 2.8 nM and 9.8 nM for hGlyT1 and rGlyT1, respectively . NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion .

D-Alanine (R)-Alanine; Ba 2776; D-α-Alanine	Structural Classification Microorganisms Classification of Application Fields Anti-aging Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
D-Alanine is a weak *GlyR* (inhibitory glycine receptor) and PMBA agonist, with an EC₅₀ of 9 mM for GlyR .

Picrotin	Structural Classification other families Iridoids Terpenoids Source classification Plants	GABA Receptor
Picrotin is an active compound, also is one of the composition of picrotoxin (an antagonist of GABAA receptors (GABAARs) and glycine receptors (GlyRs)). Picrotin has sensitivity for *GlyRs* with IC₅₀ values range from 5.2 μM to 106 μM. Picrotin can be used for the research of neurotransmission .

Colchicine 30+ Cited Publications	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields Cancer	Microtubule/Tubulin NOD-like Receptor (NLR) Autophagy Apoptosis
Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research .

Picrotin (Standard)	Structural Classification other families Iridoids Terpenoids Source classification Plants	GABA Receptor
Picrotin (Standard) is the analytical standard of Picrotin. This product is intended for research and analytical applications. Picrotin is an active compound, also is one of the composition of picrotoxin (an antagonist of GABAA receptors (GABAARs) and glycine receptors (GlyRs)). Picrotin has sensitivity for GlyRs with IC₅₀ values range from 5.2 μM to 106 μM. Picrotin can be used for the research of neurotransmission .

Colchicine (Standard)	Structural Classification Natural Products other families Source classification Plants	Microtubule/Tubulin NOD-like Receptor (NLR) Autophagy Apoptosis
Colchicine (Standard) is the analytical standard of Colchicine. This product is intended for research and analytical applications. Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research .

Sarcophine (+)-Sarcophine	Structural Classification Natural Products Neurological Disease Classification of Application Fields Animals Source classification Marine natural products Other marine organisms Disease Research Fields	Endogenous Metabolite
Sarcophine ((+)-Sarcophine) is a potent glycine receptor (GlyR) inhibitor with an IC₅₀ value of 3.9 μM. Sarcophine is a nature product that could be isolated form the Red Sea soft coral Sarcophyton glaucum .

Cat. No.	Compare	Product Name	Species	Source

HY-P74128

	GARS Protein, Human (sf9, His) Glycine--tRNA ligase; GlyRs; GARS1; GARS	Human	Sf9 insect cells
	The GARS protein performs ATP-dependent ligation of glycine to its tRNA, creating a Gly-AMP intermediate. It also produces diadenosine tetraphosphate (Ap4A) by condensing two ATP molecules, which is important for cellular regulation. GARS may have a specific role in maintaining Ap4A homeostasis. GARS Protein, Human (sf9, His) is the recombinant human-derived GARS protein, expressed by Sf9 insect cells , with N-His labeled tag.

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HY-41700S1

D-Alanine-d4
D-Alanine-d₄ is the deuterium labeled D-Alanine. D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR.

HY-41700S

D-Alanine-d3
D-Alanine-d₃ is the deuterium labeled D-Alanine. D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR.

HY-41700S3

D-Alanine-d7
D-Alanine-d₇ is the deuterium labeled D-Alanine. D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR.

HY-41700S2

D-Alanine-d1
D-Alanine-d is the deuterium labeled D-Alanine. D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR[1].

HY-16569S

Colchicine-d6
Colchicine-d₆ is the deuterium labeled Colchicine. Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM[1][2][3]. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs)[4].

HY-16569S1

Colchicine-d3
Colchicine-d₃ is the deuterium labeled Colchicine. Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM[1][2][3]. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs)[4].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83309

	GARS Antibody (YA3054) HMN5; CMT2D; DSMAV; GlyRs; SMAD1	WB, IHC-P	Human, Mouse, Rat
	GARS Antibody (YA3054) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3054), targeting GARS, with a predicted molecular weight of 83 kDa (observed band size: 75 kDa). GARS Antibody (YA3054) can be used for WB, IHC-P experiment in human, mouse, rat background.

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HY-RS05512

GLYR1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
GLYR1 Human Pre-designed siRNA Set A contains three designed siRNAs for GLYR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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GlyRs

Inhibitors & Agonists

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Natural
Products