IK | MedChemExpress (MCE) Life Science Reagents

By Targets:	5-HT Receptor (1) Endogenous Metabolite (1) HIV (1) mAChR (2) Potassium Channel (8) Small Interfering RNA (siRNA) (1) TNF Receptor (1) YAP (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (8) Infection (1) Inflammation/Immunology (2) Neurological Disease (5)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-153585

IK-930 1 Publications Verification	YAP	Cancer
IK-930 (compound I-32) is a potent and orally active TEAD inhibitor with an EC₅₀ value of <0.1 µM .

HY-112544

IK1 inhibitor PA-6 1 Publications Verification PA-6	Potassium Channel	Cardiovascular Disease
IK1 inhibitor PA-6 (PA-6), a pentamidine analogue, is a selective and potent *I_K1* (K_IR2.x ion-channel-carried inward rectifier current) inhibitor, with IC₅₀ values of 12-15 nM for human and mouse K_IR2.x currents. IK1 inhibitor PA-6 (PA-6) elevates K_IR2.1 protein expression and induces intracellular K_IR2.1 accumulation. IK1 inhibitor PA-6 (PA-6) has the potential to treat atrial fibrillation and arrhythmia .

HY-101253

AM-92016 hydrochloride 1 Publications Verification	Potassium Channel	Cardiovascular Disease
AM-92016 hydrochloride is a specific blocker of rectifier potassium current (IK). AM-92016 hydrochloride delays rectifier potassium channel (IK), repolarizes the membrane thereby restricting the duration of the nerve impulse thereby restricting the duration of the nerve impulse .

HY-15416

NS309	Potassium Channel	Cardiovascular Disease Neurological Disease
NS309 is a potent and selective activator of the Ca ²⁺-activated SK/IK potassium channels, but displays no activity at BK channels .

HY-100795A

Pirmenol hydrochloride (±)-Pirmenol hydrochloride; CI-845	mAChR Potassium Channel	Cardiovascular Disease
Pirmenol ((±)-Pirmenol) hydrochloride is an orally active antiarrhythmic agent. Pirmenol hydrochloride inhibits *I_K.ACh* (IC₅₀: 0.1 μM) by blocking mAchR. Pirmenol hydrochloride can be used in the research of cardiovascular disease, such as atrial fibrillation .

HY-118734

IK-862	TNF Receptor	Inflammation/Immunology
IK-862 is a selective inhibitor of TACE .

HY-RS06656

IK Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IK Human Pre-designed siRNA Set A contains three designed siRNAs for IK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IK Human Pre-designed siRNA Set A IK Human Pre-designed siRNA Set A

HY-120685

WAY-125971	Potassium Channel	Neurological Disease
WAY-125971, a propylamine analogue, is a potent and specific blocker of the rectifier potassium current (IK). WAY-125971 can be used for the study of arrhythmia .

HY-118317

Zacopride	Endogenous Metabolite	Cardiovascular Disease
Zacopride is a selective agonist with the activity of enhancing the inward rectifier potassium current (IK1) in rabbit hearts. Zacopride also exhibits significant antiarrhythmic effects, inhibiting ventricular arrhythmias by increasing IK1 without affecting atrial arrhythmias. Zacopride can hyperpolarize the resting membrane potential and shorten the action potential duration (APD) in a concentration-dependent manner. Zacopride significantly reduced the incidence of compound-induced early afterdepolarizations (EADs) at 1 μmol/L .

HY-100795

Pirmenol (±)-Pirmenol; CI-845 free base	mAChR Potassium Channel	Cardiovascular Disease
Pirmenol is an orally active antiarrhythmic agent. Pirmenol inhibits *I_K.ACh* (IC₅₀: 0.1 μM) by blocking mAchR. Pirmenol can be used in the research of cardiovascular disease, such as atrial fibrillation .

HY-120059

NS4591	Others	Neurological Disease
NS4591 is a modulator of calcium-activated potassium channels with activity that enhances small (SK) and intermediate (IK) conductivity. NS4591 doubled IK-mediated currents in whole-cell patch-clamp experiments at a concentration of 45 +/- 6 nM, and doubled SK3-mediated currents at a concentration of 530 +/- 100 nM. NS4591 inhibits the number of action potentials generated by suprathreshold depolarizing pulses in acutely isolated bladder primary afferent neurons. NS4591 also reduced carbakol-induced detrusor ring contraction in the rat bladder, demonstrating sensitivity to apamin .

HY-103137

Zacopride hydrochloride	5-HT Receptor	Neurological Disease
Zacopride hydrochloride is a highly potent 5-HT₃ receptor antagonist with K_is of 0.38 and 373 nM for 5-HT₃ and 5-HT₄ receptor, respectively. Zacopride hydrochloride is also a moderate *I_K1* channel agonist. Zacopride hydrochloride exerts significant antiarrhythmic and cardiac protective effects .

HY-118148

UK-66914	Potassium Channel	Cardiovascular Disease
UK-66914, is a class III antiarrhythmic agent that specifically acts on the delayed rectifier potassium current (I_K). UK-66914 is designed to prolong action potential duration (APD) and increase cardiac refractory period, thereby potentially terminating the reentry mechanism in arrhythmias without affecting the serious side effects of antiarrhythmic drugs associated with other ion channels such as Na+ and Ca2+ currents .

HY-126704

Tedisamil KC-8857	Potassium Channel	Cardiovascular Disease
Tedisamil (KC-8857) is an antiarrhythmic compound with important biological activities. Tedisamil exhibits a significant slowing effect on heart rate, which is achieved by inhibiting the transient outward potassium current (I(to)) in the atrium. Tedisamil inhibits multiple potassium currents, including IK, K(ATP), and PKA-activated chloride channels, thereby prolonging the cardiac action potential and QT interval, and increasing cardiac reentry. Tedisamil has antiarrhythmic effects on ventricular arrhythmias and atrial flutter in animal models .

HY-136805

Kv1.5-IN-1	Others	Neurological Disease
Kv1.5-IN-1 is a Kv1.5 channel inhibitor. Its target selectivity and pharmacodynamic effects were evaluated in an in vitro rat model. After the introduction of a methoxy group at the R5 position, Kv1.5-IN-1 showed inhibitory potency similar to that of the unsubstituted compound. Its IC50 value for hKv1.5 channels was 0.51 μM. Kv1.5-IN-1 exhibited a high degree of selectivity, nearly 2,600 times higher than compound Ik and 300 times higher than compound IId, indicating that it may be a safe inhibitor. Due to its good pharmacological behavior, Kv1.5-IN-1 deserves further pharmacodynamic and pharmacokinetic evaluation. These properties make Kv1.5-IN-1 a potential Kv1.5 channel inhibitor that may have application prospects in the treatment of related diseases.

HY-146365

HIV-1 inhibitor-30	HIV	Infection Inflammation/Immunology
HIV-1 inhibitor-30 (compound 10i) is a potent HIV-1 inhibitor with an EC₅₀ value of 40 nM and an IC₅₀ value of 80 nM for HIV-1 RT DNA polymerase. HIV-1 inhibitor-30 has highly antiretroviral activity against seven non-nucleoside reverse transcriptase inhibitor (NNRTI)-resistant HIV-1 strains (RT-K103N; RT-Y181C; RT-K103N,Y181C; RT-L100I,K103N; RT-Y188L; RT-K103N,G190A; RT-K103N,V108I) with IC₅₀s of 0.04~1.42 μM. HIV-1 inhibitor-30 can be used for researching AIDS .

Cat. No.	Product Name	Target	Research Area

HY-P990165

Anti-Mouse RANKL/CD254 Antibody (IK22/5)	Inhibitory Antibodies	Others
Anti-Mouse RANKL/CD254 Antibody (IK22/5) is a rat-derived IgG2a, κ type antibody inhibitor, targeting to mouse RANKL/CD254.

Cat. No.	Compare	Product Name	Species	Source

HY-P72178

	EEF1A1 Protein, Human (His-SUMO) CCS 3; CCS3; Cervical cancer suppressor 3; chunp6927; CTCL tumor antigen; EE1A1; EEF 1; EEF1A; eEF1A-1; EEF1A1; EF-1-alpha-1; EF-Tu; EF1A; EF1a lIKe protein; EF1A1_HUMAN; Elongation factor 1-alpha 1; Elongation factor Tu; GRAF 1EF; HNGC:16303; IK:tdsubc_2a3; IK:tdsubc_2b3; LENG7; member 7; PTI1; tdsubc_2a3; wu:fa91c07; wu:fa94b03; wu:fi13b09; xx:tdsubc_2a3; xx:tdsubc_2b3	Human	E. coli
	EEF1A1 is a translation elongation factor that catalyzes GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the ribosomal A site during protein synthesis. This involves mRNA codon-aa-tRNA anticodon base pairing, leading to GTP hydrolysis and aa-tRNA release in EEF1A1. EEF1A1 Protein, Human (His-SUMO) is the recombinant human-derived EEF1A1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of EEF1A1 Protein, Human (His-SUMO) is 462 a.a., with molecular weight of ~66.1 kDa.

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HY-P81282

	Ikaros Antibody (YA987) CLL associated antigen KW 6; DNA-binding protein IKaros; hIK 1; hIK-1; Hs.54452; IK1; IKaros (zinc finger protein); IKAROS; IKAROS family zinc finger 1 (IKaros); IKaros family zinc finger protein 1; IKzf1; IKZF1_HUMAN; LYF1; Lymphoid transcription factor LyF-1; PRO0758; Zinc finger protein subfamily 1A 1 (IKaros); zinc finger protein subfamily 1A 1; Zinc finger protein; subfamily 1A; member 1; ZNFN1A1.	WB, IP	Human
	Ikaros Antibody (YA987) is a mouse-derived non-conjugated IgG1 antibody (Clone NO.: YA987), targeting Ikaros, with a predicted molecular weight of 58 kDa (observed band size: 58 kDa). Ikaros Antibody (YA987) can be used for WB, IP experiment in human background.

HY-P81282A

	Ikaros Antibody (YA988) CLL associated antigen KW 6; DNA-binding protein IKaros; hIK 1; hIK-1; Hs.54452; IK1; IKaros (zinc finger protein); IKAROS; IKAROS family zinc finger 1 (IKaros); IKaros family zinc finger protein 1; IKzf1; IKZF1_HUMAN; LYF1; Lymphoid transcription factor LyF-1; PRO0758; Zinc finger protein subfamily 1A 1 (IKaros); zinc finger protein subfamily 1A 1; Zinc finger protein; subfamily 1A; member 1; ZNFN1A1.	IHC-P	Human
	Ikaros Antibody (YA988) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA988), targeting Ikaros. Ikaros Antibody (YA988) can be used for IHC-P experiment in human background.

HY-P82975

	Phospho-RPA2 (Thr21) Antibody (YA2720) 60S acidic ribosomal protein P1; AA409079; AI325195; AU020965; HSSB; IK:tdsubc_2g1; M(2)21C; MGC137236; OTTHUMP00000004008; p32; p34; RCJMB04_6d17 replication protein A2; 32kDa; REPA 2; REPA1; REPA2; Replication factor A protein 2; Replication protein A 32 kDa subunit; Replication protein A 32kDa subunit; Replication protein A 34 kDa subunit; Replication protein A; replication protein A1 (70kD); Replication Protein A2 (32kDa); Replication protein A2 32kD; Replication protein A2 32kDa; Replication protein A2; Replication protein A2; 32kDa; RF A; RF-A protein 2; Rf-A2; RFA; RFA2_HUMAN; RP A; RP-A p32; RP-A p34; RP21C; RPA 2; RPA 32; RPA; RPA2; RPA32; RPA34; RPA70; RpLP1; RpP2; xx:tdsubc_2g1; zgc:109822.	WB, IP	Human, Mouse, Rat
	Phospho-RPA2 (Thr21) Antibody (YA2720) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2720), targeting Phospho-RPA2 (Thr21), with a predicted molecular weight of 29 kDa (observed band size: 32 kDa). Phospho-RPA2 (Thr21) Antibody (YA2720) can be used for WB, IP experiment in human, mouse, rat background.

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Cat. No.	Product Name		Classification

HY-RS06656

IK Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
IK Human Pre-designed siRNA Set A contains three designed siRNAs for IK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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