UK-66914

Cat. No.: HY-118148: FAQs
Data Sheet Handling Instructions

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UK-66914, is a class III antiarrhythmic agent that specifically acts on the delayed rectifier potassium current (I_K). UK-66914 is designed to prolong action potential duration (APD) and increase cardiac refractory period, thereby potentially terminating the reentry mechanism in arrhythmias without affecting the serious side effects of antiarrhythmic drugs associated with other ion channels such as Na+ and Ca2+ currents.

For research use only. We do not sell to patients.

UK-66914 Chemical Structure

CAS No. : 113049-11-9

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Description	UK-66914, is a class III antiarrhythmic agent that specifically acts on the delayed rectifier potassium current (I_K). UK-66914 is designed to prolong action potential duration (APD) and increase cardiac refractory period, thereby potentially terminating the reentry mechanism in arrhythmias without affecting the serious side effects of antiarrhythmic drugs associated with other ion channels such as Na+ and Ca2+ currents^[1].
Molecular Weight	376.47
Formula	C₁₈H₂₄N₄O₃S
CAS No.	113049-11-9
SMILES	CS(=O)(NC1=CC=C(C=C1)C(CN2CCN(CC2)C3=CC=NC=C3)O)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (265 KB) Handling Instructions (2659 KB)
References	[1]. Rees S A, et al. Pharmacology of a methanesulfonamide IK blocker, UK66, 914[J]. Cardiovascular drug reviews, 1992, 10(2): 158-169.

UK-66914 Related Classifications

Cardiovascular Disease

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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UK-66914113049-11-9UK66914UK 66914Potassium ChannelKcsAInhibitorinhibitorinhibit

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UK-66914

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