Pirmenol hydrochloride (Synonyms: (±)-Pirmenol hydrochloride; CI-845)

Name: Pirmenol hydrochloride
Brand: MedChemExpress
SKU: HY-100795A
Rating: 4.5 (1 reviews)

Cat. No.: HY-100795A Purity: 99.06%: FAQs
Data Sheet SDS COA Handling Instructions

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Pirmenol ((±)-Pirmenol) hydrochloride is an orally active antiarrhythmic agent. Pirmenol hydrochloride inhibits I_K.ACh (IC₅₀: 0.1 μM) by blocking mAchR. Pirmenol hydrochloride can be used in the research of cardiovascular disease, such as atrial fibrillation.

For research use only. We do not sell to patients.

Pirmenol hydrochloride Chemical Structure

CAS No. : 61477-94-9

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 61	In-stock	Estimated Time of Arrival: December 31
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10 mM * 1 mL in DMSO	USD 61	In-stock	Estimated Time of Arrival: December 31
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5 mg	USD 55	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of Pirmenol hydrochloride:

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mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

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References
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Description

IC₅₀ & Target

IC50: 0.1 μM (I_K.ACh)^[1]

In Vitro

Pirmenol (1 μM) hydrochloride inhibits the I_K.ACh induced by carbachol or intracellular loading of GTPg S in in atrial cells^[1].
Pirmenol (5 μM) hydrochloride depresses the early part of the plateau and lengthened the final repolarization of the action potentials in ventricular myocytes^[3].
Pirmenol (1 μM) hydrochloride prolongs the action potential duration at 90% repolarization in atrial muscles and Purkinje fibers^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pirmenol (2.5 and 5 mg/kg, p.o.) hydrochloride is effective against the arrhythmias in conscious, coronary artery ligated dogs^[4].
Pirmenol (rats) hydrochloride shows LD₅₀s of 359.9 mg/kg (p.o), 23.6 mg/kg (i.v.)^[2].
Pirmenol (mice) hydrochloride shows LD₅₀s of 215.5 mg/kg (p.o), 20.8 mg/kg (i.v.)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Conscious, coronary artery ligated dogs^[4]
Dosage:	Oral administration (p.o.)
Administration:	2.5 and 5 mg/kg
Result:	Restored normal sinus rhythm, and showed a long duration of activity, wide safety margin.

Molecular Weight

374.95

Formula

C₂₂H₃₁ClN₂O

CAS No.

61477-94-9

Appearance

Solid

Color

White to yellow

SMILES

OC(C1=CC=CC=C1)(CCCN2[C@@H](C)CCC[C@H]2C)C3=CC=CC=N3.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (266.70 mM; Need ultrasonic)

DMSO : 66.67 mg/mL (177.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6670 mL	13.3351 mL	26.6702 mL
5 mM	0.5334 mL	2.6670 mL	5.3340 mL
10 mM	0.2667 mL	1.3335 mL	2.6670 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (5.55 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (5.55 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (5.55 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.34%

Select Batch:

Data Sheet (277 KB) SDS (393 KB)

COA (252 KB) HNMR (444 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Watanabe Y, et al. Pirmenol inhibits muscarinic acetylcholine receptor-operated K+ current in the guinea pig heart. Eur J Pharmacol. 1997 Oct 29;338(1):71-4. [Content Brief]

[2]. Schardein JL, et al. Preclinical toxicology studies with a new antiarrhythmic agent: Pirmenol hydrochloride (CI-845). Toxicol Appl Pharmacol. 1980 Nov;56(2):294-301. [Content Brief]

[3]. T Sawanobori, et al. Electrophysiologic and antiarrhythmic actions of pirmenol on rabbit and guinea pig cardiac preparations. J Cardiovasc Pharmacol. 1990 Dec;16(6):975-83. [Content Brief]

[4]. T E Mertz, et al. Pirmenol hydrochloride (CI-845): antiarrhythmic profile in coronary artery ligated conscious dogs. J Cardiovasc Pharmacol. 1980 Sep-Oct;2(5):527-41. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	2.6670 mL	13.3351 mL	26.6702 mL	66.6756 mL
	5 mM	0.5334 mL	2.6670 mL	5.3340 mL	13.3351 mL
	10 mM	0.2667 mL	1.3335 mL	2.6670 mL	6.6676 mL
	15 mM	0.1778 mL	0.8890 mL	1.7780 mL	4.4450 mL
	20 mM	0.1334 mL	0.6668 mL	1.3335 mL	3.3338 mL
	25 mM	0.1067 mL	0.5334 mL	1.0668 mL	2.6670 mL
	30 mM	0.0889 mL	0.4445 mL	0.8890 mL	2.2225 mL
	40 mM	0.0667 mL	0.3334 mL	0.6668 mL	1.6669 mL
	50 mM	0.0533 mL	0.2667 mL	0.5334 mL	1.3335 mL
	60 mM	0.0445 mL	0.2223 mL	0.4445 mL	1.1113 mL
	80 mM	0.0333 mL	0.1667 mL	0.3334 mL	0.8334 mL
	100 mM	0.0267 mL	0.1334 mL	0.2667 mL	0.6668 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Pirmenol hydrochloride Related Classifications

Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Pirmenol hydrochloride (Synonyms: (±)-Pirmenol hydrochloride; CI-845)

Customer Review

Other Forms of Pirmenol hydrochloride:

Pirmenol hydrochloride Related Antibodies

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All mAChR Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Pirmenol hydrochloride Related Antibodies

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Complete Stock Solution Preparation Table

Pirmenol hydrochloride Related Classifications

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