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Limonoids

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By Targets:	Akt (1) Apoptosis (5) Bacterial (3) Caspase (1) Cytochrome P450 (1) Dengue virus (1) EBV (1) Flavivirus (1) Fungal (2) Histamine Receptor (1) HSP (2) Influenza Virus (1) NO Synthase (1) P-glycoprotein (1) Parasite (5) Phosphatase (1) PPAR (1)
By Research Areas:	Cancer (9) Infection (10) Inflammation/Immunology (5) Metabolic Disease (5) Neurological Disease (2)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0547

Nomilin 1 Publications Verification	Others	Metabolic Disease
Nomilin is a limonoid compound obtained from the extracts of citrus fruits. Nomilin is an anti-obesity and anti-hyperglycemic agent .

HY-N3698

Deacetylsalannin	Others	Others
Deacetylsalannin is a limonoid on peach leaves .

HY-N3944

Glaucin B 6β-Acetoxy-5-epilimonin	Others	Others
Glaucin B is a bitter limonoid isolated from the root bark of Evodia glauca .

HY-N3150

Ohchinin acetate	Others	Others
Ohchinin acetate is a limonoid, that can be isolated from the fruit of M. azedarach Linn. var. japonica Makino .

HY-N3285

Methyl 6-acetoxyangolensate	Others	Others
Methyl 6-acetoxyangolensate (compound 37) is a limonoid, which can be isolated from isolated the leaves and twigs of Khaya senegalensis .

HY-N3444

Jangomolide	Others	Others
Jangomolide is a natural product, a limonoid isolated from flacourtia jangomas .

HY-N3151

Ohchinin	Others	Others
Ohchinin is a limonoid, that can be isolated from the fruit of Melia azedarach L. .

HY-122959

Kihadanin B	Akt PPAR	Metabolic Disease
Kihadanin B is a citrus limonoid that can be purified from the peels of immature Citrus unshiu. Kihadanin B suppresses adipogenesis through repression of the Akt-FOXO1-PPARγ axis in 3T3-L1 adipocytes .

HY-N1621

1-Deacetylnimbolinin B	Fungal Parasite	Infection
1-Deacetylnimbolinin B is a nimbolinin-type limonoid isolated from the fruits of Melia toosendan. Limonoids are a class of highly oxygenated nortriterpenoids that exhibit insecticidal, antifungal, nematicidal and cytotoxic properties .

HY-N9232

Rutaevin 7-acetate	Others	Others
Rutaevin 7-acetate (compound 1) is a limonoid .

HY-N0547R

Nomilin (Standard)	Others	Metabolic Disease
Nomilin (Standard) is the analytical standard of Nomilin. This product is intended for research and analytical applications. Nomilin is a limonoid compound obtained from the extracts of citrus fruits. Nomilin is an anti-obesity and anti-hyperglycemic agent .

HY-N8405

Isolimonexic acid	Cytochrome P450	Cancer
Isolimonexic acid is a limonoid isolated from lemon (Citrus lemon L. Burm) seed, has anti-cancer and anti-aromatase (IC₅₀=25.60 μM) properties .

HY-N9615

Azadiradione	HSP	Infection Neurological Disease Inflammation/Immunology
Azadiradione is a bioactive limonoid found in Azadirachta indica. Azadiradione is a HSF1 activator. Azadiradione has antimycobacterial, anti-nociceptive and anti-inflammatory activities .

HY-N3561

Cedrelone	Apoptosis	Cancer
Cedrelone, a limonoid, is a Phenazine biosynthesis-like domain-containing protein (PBLD) activator. Cedrelone induces cancer cell apoptosis, and possess antitumor effects .

HY-N3694

Deacetylnimbin Desacetyl nimbin	Others	Others
Deacetylnimbin is a limonoid isolated from Azadirachta indica. Deacetylnimbin can be used as a plant metabolite, a food repellent and as a growth regulator for insects such as S. litura, P. ricini and O. fscovittata .

HY-N10096

Epoxyazadiradione	Parasite	Infection
Epoxyazadiradione is a limonoid purified from neem (Azadirachta indica) fruits. Epoxyazadiradione inhibits the tautomerase activity of MIF of both human (huMIF) and malaria parasites (Plasmodium falciparum (PfMIF) and Plasmodium yoelii (PyMIF)) non-competitively in a reversible fashion (K_i, 2.11-5.23 μM). Epoxyazadiradione has the potential against proinflammatory reactions induced by MIF of both malaria parasites and human .

HY-N3187

Nimbin	Flavivirus Dengue virus Fungal Bacterial Histamine Receptor	Infection Neurological Disease Inflammation/Immunology Cancer
Nimbin is a intermediate limonoid isolated from Azadirachta. Nimbin prevents tau aggregation and increases cell viability. Nimbin is effective inhibits the envelope protein of dengue virus. Nimbin has anti-inflammatory, antipyretic, antifungal, antihistamine, antiseptic, antioxidant, anti-cancer and anti-viral properties. Nimbin can across blood-brain barrier .

HY-N10091

2,3-Dihydro-3α-methoxynimbolide	Apoptosis	Others
2,3-Dihydro-3α-methoxynimbolide is a limonoid compound isolated from the extracts of bark, leaves, roots, and seeds of Azadirachta indica A. Juss. var. siamensis Valeton. 2,3-Dihydro-3α-methoxynimbolide exhibits potent cyto-toxicities against one or more cell lines. 2,3-Dihydro-3α-methoxynimbolide activates caspases-3, -8, and -9, while increases the ratio of Bax/Bcl-2. 2,3-Dihydro-3α-methoxynimbolide induces apoptosis via both mitochondrial and death receptor pathways in AZ521 .

HY-N1075

Walsuronoid B	Parasite	Infection
Walsuronoid B is a limonoid can be isolated from Walsura robusta and has weak antimalarial activity .

HY-N7694

Isotoosendanin	Others	Inflammation/Immunology
Isotoosendanin is a limonoid that can be isolated from Melia toosendan fruit. Isotoosendanin displays significant anti-inflammatory and analgesic activities .

HY-N0689

Evodine	P-glycoprotein	Cancer
Evodine, the major limonoid of Evodiae Fuctus, is a potent P-gp inhibitor. Evodine has protection against glutamateinduced toxicity by preserving the antioxidant defense system .

HY-N8761

Kihadanin A	NO Synthase	Metabolic Disease
Kihadanin A (compound 3) is a limonoid NOS3 inhibitor that can be isolated from the methanol extract of Dictamnus dasycarpus root bark. Kihadanin A is useful in the study of hyperuricemia (HUA) [3].

HY-123026

Salannin	Bacterial	Infection
Salannin, a limonoid bitter principle of the seed oil of Azadirachta indica, shows antiulcer and spermicidal activities. Salannin displays antibacterial activity towards both Gram-positive and Gram-negative bacteria .

HY-N3283

6-Methylhydroxyangolensate	Parasite	Infection
6-Methylhydroxyyangolensate is a limonoid can be extracted from Khaya grandifoliola. 6-Methylhydroxyyangolensate has low antimalarial activity in vitro, with an IC₅₀ of 21.59 μg/ml against P. falciparum (W2/Indochina clone) .

HY-N0428

Obacunone 1 Publications Verification	Apoptosis	Cancer
Obacunone is a highly oxidized triterpenoid limonoid isolated from citrus plants. Obacunone exerts its anticancer effects by inducing apoptosis. Obacunone also protects retinal pigment epithelial (RPE) cells from ultraviolet (UV) radiation (UVR)-induced oxidative damage .

HY-126589

Rohitukin	Others	Others
Rohitukin is a limonoid, which can be isolated from Turraea obtusifolia. Rohitukin is an antagonist for insect hormone 20-hydroxyecdysone (20-E) with ED₅₀ of 125 μM. Rohitukin explains the strategy for plants defend against insect predation, and can be used for research about insect control .

HY-N1710

28-Deoxonimbolide	Apoptosis Caspase	Cancer
28-Deoxonimbolide is a nimbin (HY-N3187) type limonoid, that can be isolated from Azadirachta indica seed extracts. 28-Deoxonimbolide shows anticancer activity. 28-Deoxonimbolide induces apoptotic cell death in HL60 cells via both the mitochondrial- and the death receptor-mediated pathways .

HY-133108

Azadirachtin B	EBV Parasite Phosphatase Influenza Virus	Infection Metabolic Disease Inflammation/Immunology Cancer
Azadirachtin B is an limonoid isolated from seed kernels of Azadirachta indica. Azadirachtin B increases alkaline phosphatase (ALP) activity and stimulates osteoblast differentiation. Azadirachtin B is active against the Epstein-Barr virus early antigen (EBV-EA). Azadirachtin B has insecticidal, nematocidal, anticancer, anti-inflammatory, antiviral and osteogenic properties .

HY-107577

Gedunin	HSP	Infection Inflammation/Immunology Cancer
Gedunin is a limonoid with anti-cancer, anti-viral, anti-inflammatory and insecticidal activities. Gedunin acts as a potent Hsp90 inhibitor and induces the degradation of Hsp90-dependent client proteins. Geduni may obstructs the entry of SARS-CoV-2 virus into human host cells and can be used for COVID-19 research .

HY-N0428R

Obacunone (Standard)	Apoptosis	Cancer
Obacunone (Standard) is the analytical standard of Obacunone. This product is intended for research and analytical applications. Obacunone is a highly oxidized triterpenoid limonoid isolated from citrus plants. Obacunone exerts its anticancer effects by inducing apoptosis. Obacunone also protects retinal pigment epithelial (RPE) cells from ultraviolet (UV) radiation (UVR)-induced oxidative damage .

HY-117901

Sandoricin	Others	Others
Sandoricin is a limonoid compound that can be extracted from the seeds of Sandoricum koetjape. Sandoricin exhibits strong antifeedant properties in larvae of Fall Armyworm (Spodoptera frugiperda) and European Corn Borer (Ostrinia nubilalis) fed on artificial diets. Sandoricin induces reduced growth rate and delayed pupation at lower doses, while higher doses cause massive mortality of larvae. Sandoricin is a potential field insecticide .

HY-N1654

2',3'-Dehydrosalannol	Bacterial	Infection
2',3'-Dehydrosalannol is a potent antibacterial agent. 2',3'-Dehydrosalannol shows antibacterial activity against K. pneumonia ATCC 13883, P. aeruginosa ATCC 27853, S. aureus ATCC 25922, E. coli ATCC 11775, and E. faecalis ATCC 10541, with MIC values of 0.78, 1.56, 1.56, 6.25, and 25 µg/mL, respectively .

Nomilin 1 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Rutaceae Metabolic Disease Plants Citrus Disease Research Fields	Others
Nomilin is a limonoid compound obtained from the extracts of citrus fruits. Nomilin is an anti-obesity and anti-hyperglycemic agent .

Deacetylsalannin	Structural Classification Natural Products Source classification Rosaceae Plants Amygdalus persica L.	Others
Deacetylsalannin is a limonoid on peach leaves .

Glaucin B 6β-Acetoxy-5-epilimonin	Triterpenes Structural Classification Terpenoids Source classification Rutaceae Plants Tetradium ruticarpum (A. Jussieu) T. G. Hartley	Others
Glaucin B is a bitter limonoid isolated from the root bark of Evodia glauca .

Ohchinin acetate	Triterpenes Structural Classification Melia azedarach Linn. Terpenoids Source classification Plants Meliaceae	Others
Ohchinin acetate is a limonoid, that can be isolated from the fruit of M. azedarach Linn. var. japonica Makino .

Methyl 6-acetoxyangolensate	Structural Classification Natural Products Source classification Plants Meliaceae	Others
Methyl 6-acetoxyangolensate (compound 37) is a limonoid, which can be isolated from isolated the leaves and twigs of Khaya senegalensis .

Jangomolide	Triterpenes Structural Classification Terpenoids Source classification Plants Compositae Vachellia nilotica (L.) P. J. H. Hurter & Mabb.	Others
Jangomolide is a natural product, a limonoid isolated from flacourtia jangomas .

Ohchinin	Triterpenes Structural Classification Melia azedarach Linn. Terpenoids Source classification Plants Meliaceae	Others
Ohchinin is a limonoid, that can be isolated from the fruit of Melia azedarach L. .

Kihadanin B	Other Terpenoids Structural Classification Terpenoids Dictamnus dasycarpus Turcz. Source classification Rutaceae Plants	Akt PPAR
Kihadanin B is a citrus limonoid that can be purified from the peels of immature Citrus unshiu. Kihadanin B suppresses adipogenesis through repression of the Akt-FOXO1-PPARγ axis in 3T3-L1 adipocytes .

1-Deacetylnimbolinin B	Natural Products Melia azedarach Linn. Source classification Plants Meliaceae	Fungal Parasite
1-Deacetylnimbolinin B is a nimbolinin-type limonoid isolated from the fruits of Melia toosendan. Limonoids are a class of highly oxygenated nortriterpenoids that exhibit insecticidal, antifungal, nematicidal and cytotoxic properties .

Rutaevin 7-acetate	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Microula sikkimensis (Clarke) Hemsl. Plants Disease Research Fields Boraginaceae	Others
Rutaevin 7-acetate (compound 1) is a limonoid .

Nomilin (Standard)	Triterpenes Structural Classification Terpenoids Source classification Rutaceae Plants Citrus	Others
Nomilin (Standard) is the analytical standard of Nomilin. This product is intended for research and analytical applications. Nomilin is a limonoid compound obtained from the extracts of citrus fruits. Nomilin is an anti-obesity and anti-hyperglycemic agent .

Isolimonexic acid	Structural Classification Natural Products Classification of Application Fields Citrus limon (L.) Burm. F. Source classification Rutaceae Plants Disease Research Fields Cancer	Cytochrome P450
Isolimonexic acid is a limonoid isolated from lemon (Citrus lemon L. Burm) seed, has anti-cancer and anti-aromatase (IC₅₀=25.60 μM) properties .

Azadiradione	Triterpenes other families Neurological Disease Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields Biological Pesticide Research Agricultural Research	HSP
Azadiradione is a bioactive limonoid found in Azadirachta indica. Azadiradione is a HSF1 activator. Azadiradione has antimycobacterial, anti-nociceptive and anti-inflammatory activities .

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Limonoids

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