2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. HSP
  4. Gedunin

Gedunin is a limonoid with anti-cancer, anti-viral, anti-inflammatory and insecticidal activities. Gedunin acts as a potent Hsp90 inhibitor and induces the degradation of Hsp90-dependent client proteins. Geduni may obstructs the entry of SARS-CoV-2 virus into human host cells and can be used for COVID-19 research.

For research use only. We do not sell to patients.

Gedunin Chemical Structure

Gedunin Chemical Structure

CAS No. : 2753-30-2

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1 mg USD 500 In-stock
5 mg USD 1500 In-stock
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Based on 1 publication(s) in Google Scholar

Gedunin Related Antibodies

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Description

Gedunin is a limonoid with anti-cancer, anti-viral, anti-inflammatory and insecticidal activities. Gedunin acts as a potent Hsp90 inhibitor and induces the degradation of Hsp90-dependent client proteins. Geduni may obstructs the entry of SARS-CoV-2 virus into human host cells and can be used for COVID-19 research[3].

IC50 & Target[2]

HSP90

 

In Vitro

Gedunin (0.5-30 μM) inhibits CaCo-2 colon cancer cell proliferationin a dose-dependent manner, and the IC50 value is 16.83 µM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gedunin Related Antibodies
Molecular Weight

482.57

Formula

C28H34O7
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1[C@](O2)([H])[C@@]32[C@](CC[C@]4([H])[C@@]5(C)C=CC(C(C)(C)[C@]5([H])C[C@@H](OC(C)=O)[C@]43C)=O)(C)[C@H](C6=COC=C6)O1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 48.26 mg/mL (100.01 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0722 mL 10.3612 mL 20.7224 mL
5 mM 0.4144 mL 2.0722 mL 4.1445 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (262 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0722 mL 10.3612 mL 20.7224 mL 51.8060 mL
5 mM 0.4144 mL 2.0722 mL 4.1445 mL 10.3612 mL
10 mM 0.2072 mL 1.0361 mL 2.0722 mL 5.1806 mL
15 mM 0.1381 mL 0.6907 mL 1.3815 mL 3.4537 mL
20 mM 0.1036 mL 0.5181 mL 1.0361 mL 2.5903 mL
25 mM 0.0829 mL 0.4144 mL 0.8289 mL 2.0722 mL
30 mM 0.0691 mL 0.3454 mL 0.6907 mL 1.7269 mL
40 mM 0.0518 mL 0.2590 mL 0.5181 mL 1.2951 mL
50 mM 0.0414 mL 0.2072 mL 0.4144 mL 1.0361 mL
60 mM 0.0345 mL 0.1727 mL 0.3454 mL 0.8634 mL
80 mM 0.0259 mL 0.1295 mL 0.2590 mL 0.6476 mL
100 mM 0.0207 mL 0.1036 mL 0.2072 mL 0.5181 mL
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Gedunin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gedunin2753-30-2HSPHeat shock proteinsAlzheimer's diseaseneurodegenerative disorderADCOVID-19SARS-CoV-2HSP90Inhibitorinhibitorinhibit

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