NEDD8

By Targets:	Apoptosis (1) E1/E2/E3 Enzyme (2) Microtubule/Tubulin (1) NEDD8-activating Enzyme (6) PD-1/PD-L1 (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (10)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10484

Pevonedistat hydrochloride Maximum Cited Publications 142 Publications Verification MLN4924 hydrochloride	NEDD8-activating Enzyme	Cancer
Pevonedistat hydrochloride (MLN4924 hydrochloride) is a potent and selective NEDD8-activating enzyme (NAE) inhibitor, with an IC₅₀ of 4.7 nM .

HY-70062

Pevonedistat Maximum Cited Publications 142 Publications Verification MLN4924	NEDD8-activating Enzyme	Cancer
Pevonedistat (MLN4924) is a potent and selective NEDD8-activating enzyme (NAE) inhibitor with an IC₅₀ of 4.7 nM .

HY-115537

NAE-IN-M22	Apoptosis	Cancer
NAE-IN-M22 is a potent, selective and reversible inhibitor of NEDD8 activating enzyme (NAE), with potency in micromolar range. NAE-IN-M22 inhibits multiple cancer cell lines and induces apoptosis in A549 cells. NAE-IN-M22 also can inhibit tumor growth in vivo .

HY-128586

TAS4464 5 Publications Verification	NEDD8-activating Enzyme	Cancer
TAS4464 is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE), with an IC₅₀ of 0.955 nM .

HY-101790A

ZM223 hydrochloride	NEDD8-activating Enzyme	Cancer
ZM223 hydrochloride is an orally active, potent non-covalent NEDD8 activating enzyme (NAE) inhibitor with excellent anticancer activity .

HY-163105

Tubulin/NEDDylation-IN-1	Microtubule/Tubulin	Cancer
Tubulin/NEDDylation-IN-1 (compound C11) is a dual inhibitor of tubulin (Microtubule/Tubulin)-NEDDylation (IC₅₀ for tubulin=2.40 μM), which has strong anti-proliferative activity. Neddylation is a protein post-translational modification that covalently tags the ubiquitin-like protein NEDD8 to target proteins. Tubulin/NEDDylation-IN-1 forms hydrogen bonds with residues of tubulin and E1 NEDD8 activating enzyme (NAE) through methoxy and dithiocarbamate groups and inhibits NEDDylation and microtubulin in an ATP-dependent manner. tube polymerization .

HY-128586A

TAS4464 hydrochloride 5 Publications Verification	NEDD8-activating Enzyme	Cancer
TAS4464 (hydrochloride) is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE), with an IC₅₀ of 0.955 nM . TAS4464 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-RS09181

NEDD8 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NEDD8 Human Pre-designed siRNA Set A contains three designed siRNAs for NEDD8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NEDD8 Human Pre-designed siRNA Set A NEDD8 Human Pre-designed siRNA Set A

HY-101790

ZM223	NEDD8-activating Enzyme	Cancer
ZM223 is a potent non-covalent NEDD8 activating enzyme (NAE) inhibitor, orally active .

HY-159601

CSN5-IN-1	PD-1/PD-L1 E1/E2/E3 Enzyme	Cancer
CSN5-IN-1 (compound Ac-11) is an inhibitor of CSN5, with IC₅₀ values of 12.56 μM and 19 μM as measured by FP assay and fluorescence assay, respectively. CSN5-IN-1 can also downregulate the expression of PD-L1 and upregulate the expression of NEDD8-Cul1 in cells .

HY-108702

ML-792 20+ Cited Publications	E1/E2/E3 Enzyme	Cancer
ML-792 is a potent and selective inhibitor of SAE/SUMO1 and SAE/SUMO2 in enzymatic assays (IC₅₀ values of 3 and 11 nM, respectively) compared with NAE/NEDD8 and UAE/ubiquitin (IC₅₀> values of 32 μM and >100 μM, respectively) .

Cat. No.	Product Name	Target	Research Area

HY-P5022

*Cullin-Associated NEDD8-Dissociated Protein 1 (548-566)*	Peptides	Others
Cullin-Associated NEDD8-Dissociated Protein 1 (548-566) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

Recombinant Proteins Recommended:

NEDD8

Species:	Human (4)
Tag:	His (2) Tag Free (2)
Source:	E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P70843

	NEDD8 Protein, Human Neural precursor cell expressed developmentally down-regulated protein 8; NEDD8; NEDDylin; Ubiquitin-like protein NEDD8	Human	E. coli
	NEDD8 is an important ubiquitin-like protein that plays a key role in cell cycle regulation and embryogenesis by binding to specific proteins such as cullin and p53/TP53. Its binding to cullin is critical for recruiting E2 enzymes to the cullin-RING-based E3 ubiquitin-protein ligase complex, thereby enabling degradation of regulatory proteins. NEDD8 Protein, Human is the recombinant human-derived NEDD8 protein, expressed by E. coli , with tag free. The total length of NEDD8 Protein, Human is 76 a.a., with molecular weight of ~9.0 kDa.

HY-P71406

	UBE2M Protein, Human NEDD8-conjugating enzyme Ubc12; NEDD8 carrier protein; NEDD8 protein ligase; Ubiquitin-conjugating enzyme E2 M; UBC12; UBE2M;	Human	E. coli
	UBE2M Protein is a crucial mediator in the ubiquitin-like protein NEDD8 conjugation pathway. It accepts NEDD8 from the UBA3-NAE1 E1 complex, covalently attaching it to target proteins like CUL1, CUL2, CUL3, and CUL4, particularly interacting with the E3 ubiquitin ligase RBX1. This specificity in neddylating specific targets suggests a pivotal role in regulating cellular processes, notably contributing to cell proliferation. UBE2M Protein, Human is the recombinant human-derived UBE2M protein, expressed by E. coli , with tag free. The total length of UBE2M Protein, Human is 183 a.a., with molecular weight of 19-25.0 kDa.

HY-P76688A

	UBE2F Protein, Human (His, Solution) NEDD8-conjugating enzyme UBE2F; NCE2	Human	E. coli
	The UBE2F protein accepts NEDD8 from the UBA3-NAE1 E1 complex and covalently links it to various target proteins in the ubiquitin-like NEDD8 conjugation pathway. The RBX2-UBE2F complex specifically interacts with the E3 ubiquitin ligase RBX2, but not RBX1, for the neddylation of specific targets, especially CUL5. UBE2F Protein, Human (His, Solution) is the recombinant human-derived UBE2F, expressed by E. coli , with N-6*His labeled tag. ,

HY-P71290

	SENP8 Protein, Human (His) Sentrin-Specific Protease 8; DeNEDDylase-1; NEDD8-Specific Protease 1; Protease Cysteine 2; Sentrin/SUMO-Specific Protease SENP8; SENP8; DEN1; NEDP1; PRSC2	Human	E. coli
	SENP8 protein, a pivotal protease in the NEDD8 pathway, plays a dual role in catalyzing the processing of full-length NEDD8 into its mature form and facilitating the deconjugation of NEDD8 from specific target proteins, including cullins and p53. SENP8's dual functionality underscores its crucial role in regulating NEDD8 modification, impacting various cellular pathways and functions. SENP8 Protein, Human (His) is the recombinant human-derived SENP8 protein, expressed by E. coli , with N-6*His labeled tag. The total length of SENP8 Protein, Human (His) is 212 a.a., with molecular weight of ~22.0 kDa.

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HY-P80240

	NEDD8 Antibody	WB, ICC/IF, IHC-P, IP	Human, Rat
	NEDD8 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 9 kDa, targeting to NEDD8. It can be used for WB,ICC/IF,IHC-P,IP assays with tag free, in the background of Human, Rat.

HY-P82386

	APPBP1 Antibody (YA2131) NEDD8 activating enzyme E1 subunit 1; HPP1; ula-1; APPBP1; A-116A10.1	WB, IP	Human
	APPBP1 Antibody (YA2131) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2131), targeting APPBP1, with a predicted molecular weight of 60 kDa (observed band size: 60 kDa). APPBP1 Antibody (YA2131) can be used for WB, IP experiment in human background.

HY-P83551

	NEDD8 Activating Enzyme E1C Antibody (YA3296) NAE2; UBE1C; hUBA3	WB	Human, Mouse
	NEDD8 Activating Enzyme E1C Antibody (YA3296) is a biotin-conjugated non-conjugated IgG antibody, targeting NEDD8 Activating Enzyme E1C, with a predicted molecular weight of 52 kDa (observed band size: 52 kDa). NEDD8 Activating Enzyme E1C Antibody (YA3296) can be used for WB experiment in human, mouse background.

HY-P83546

	NCE2 Antibody (YA3291) NCE2; NEDD8 carrier protein UBE2F; NEDD8 protein ligase UBE2F; NEDD8-conjugating enzyme 2	WB, IHC-F, IHC-P, ICC/IF	Human
	NCE2 Antibody (YA3291) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3291), targeting NCE2, with a predicted molecular weight of 21 kDa (observed band size: 21 kDa). NCE2 Antibody (YA3291) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human background.

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Cat. No.	Product Name		Classification

HY-RS09181

NEDD8 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
NEDD8 Human Pre-designed siRNA Set A contains three designed siRNAs for NEDD8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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