Palmitoyl CoA

By Targets:	Endogenous Metabolite (4) GCGR (2) GLP Receptor (2) Mitochondrial Metabolism (1) Neuropeptide FF Receptor (2)
By Research Areas:	Cardiovascular Disease (1) Inflammation/Immunology (2) Metabolic Disease (7) Neurological Disease (3)

Targets Recommended: Stearoyl-CoA Desaturase (SCD) HMG-CoA Reductase (HMGCR) Acetyl-CoA Carboxylase Acyltransferase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-134427

Palmitoyl coenzyme A lithium Palmitoyl CoA lithium	Endogenous Metabolite	Metabolic Disease
Palmitoyl coenzyme A lithium is an acyl-CoA thioester that can be transported into the mitochondrial matrix via the carnitine shuttle system and is involved in β-oxidation. Palmitoyl coenzyme A lithium can also be used as a substrate for sphingosine biosynthesis .

HY-136408

Malonyl CoA lithium Malonyl coenzyme A lithium	Mitochondrial Metabolism	Metabolic Disease
Malonyl CoA (Malonyl Coenzyme A) lithium is an inhibitor of carnitine palmitoyl transferase 1 (CPT1). High Malonyl CoA lithium concentrations suppress fatty acid oxidation, while low Malonyl CoA lithium concentrations are permissive for fat oxidation .

HY-E70264

16:0 Coenzyme A triammonium	Endogenous Metabolite	Metabolic Disease
16:0 Coenzyme A triammonium is palmitoyl-CoA, which can serve as a reaction substrate to transfer the palmitoyl group to the free thiol group of the target protein through palmitoylation catalyzed by protein acyl transferases (PATs) .

HY-139451

ELOVL6-IN-3	Others	Neurological Disease
ELOVL6-IN-1 is a potent, orally active and selective ELOVL6 inhibitor. ELOVL6-IN-1 dose-dependently inhibits mouse ELOVL6 activities, with an IC₅₀ value of 0.350 μM. ELOVL6-IN-1 inhibits ELOVL6 in a noncompetitive manner for malonyl-CoA (K_i=994 nM) and palmitoyl-CoA .

HY-154922

Palmitoyl coenzyme A Palmitoyl CoA	Endogenous Metabolite	Metabolic Disease
Palmitoyl coenzyme A is an acyl-CoA thioester that can be transported into the mitochondrial matrix via the carnitine shuttle system and is involved in β-oxidation. Palmitoyl coenzyme A can also be used as a substrate for sphingosine biosynthesis .

HY-166328

Palmitoyl coenzyme A potassium Palmitoyl CoA potassium	Others	Metabolic Disease
Palmitoyl coenzyme A (potassium) (Palmitoyl CoA (potassium)) is an ester product.

HY-E70252

1-Pyrenebutanoyl-CoA	Endogenous Metabolite	Cardiovascular Disease
1-Pyrenebutanoyl-CoA is a type of coenzyme A that can non-competitively inhibit (K_i = 2 μM) phosphorylating (ADP-stimulated) respiration in rat liver mitochondria, and competitively inhibit (K_i = 2.1 μM and 15 μM) *carnitine palmitoyl-CoA* transferase and octanoyl-CoA transferase** .

HY-P10379

palm-PrRP31	Neuropeptide FF Receptor	Others Neurological Disease
palm-PrRP31 is a potent dual receptor agonist for both GPR10 (EC₅₀=72 pM) and NPFF-R2. palm-PrRP31 activates downstream signaling pathways through binding to its receptors, GPR10 and NPFF-R2, which results in reduced appetite and increased energy expenditure. Utilizing palm-PrRP31 facilitates the study of the mechanism of action in the nervous system, thereby elucidating the complex biological processes that regulate appetite and energy expenditure .

HY-P10380

palm11-PrRP31	Neuropeptide FF Receptor	Neurological Disease
palm11-PrRP31 is a lipidized endogenous appetite inhibitory neuropeptide (PrRP) analogue. palm11-PrRP31 is GPR10 (EC₅₀=39 pM) and NPFF-R2 effective dual agonists. palm11-PrRP31 is able to mimic the natural function of PrRP by binding to these receptors to reduce food intake. palm11-PrRP31 can be used as a potential anti-obesity agent and for the study of neuropeptide-receptor interaction .

HY-P10031

SAR441255	GLP Receptor GCGR	Metabolic Disease
SAR441255 is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. SAR441255 displays high potency with balanced activation of all three target receptors.?SAR441255 shows positive acute glucoregulatory effectss in diabetic obese monkeys .

HY-P10031A

SAR441255 TFA	GLP Receptor GCGR	Metabolic Disease
SAR441255 TFA is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. SAR441255 TFA displays high potency with balanced activation of all three target receptors. SAR441255 TFA shows positive acute glucoregulatory effectss in diabetic obese monkeys .

Cat. No.	Product Name	Type

HY-134427

Palmitoyl coenzyme A lithium Palmitoyl CoA lithium	Drug Delivery
Palmitoyl coenzyme A lithium is an acyl-CoA thioester that can be transported into the mitochondrial matrix via the carnitine shuttle system and is involved in β-oxidation. Palmitoyl coenzyme A lithium can also be used as a substrate for sphingosine biosynthesis .

HY-154922

Palmitoyl coenzyme A Palmitoyl CoA	Enzyme Substrates
Palmitoyl coenzyme A is an acyl-CoA thioester that can be transported into the mitochondrial matrix via the carnitine shuttle system and is involved in β-oxidation. Palmitoyl coenzyme A can also be used as a substrate for sphingosine biosynthesis .

Cat. No.	Product Name	Target	Research Area

HY-P0064

Palmitoyl Tetrapeptide-3	Peptides	Inflammation/Immunology
Palmitoyl Tetrapeptide-3 is a synthetic peptide corresponding to amino acids 341-344 of the human immunoglobulin heavy chain, with the ability to stimulate phagocytosis. It also has anti-inflammatory and anti-aging effects, reducing skin wrinkles by promoting the production of elastic fibers in the papillary dermis .

HY-P10031A

SAR441255 TFA	GLP Receptor GCGR	Metabolic Disease
SAR441255 TFA is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. SAR441255 TFA displays high potency with balanced activation of all three target receptors. SAR441255 TFA shows positive acute glucoregulatory effectss in diabetic obese monkeys .

HY-P10441

*S-palm* P0(180–199)**	Peptides	Inflammation/Immunology
S-palm P0(180-199) is a polypeptide that increases MHC Class II limiting reactions. S-palm P0(180-199) can be used to establish a model of chronic inflammatory demyelinating multiple radiculopathy (CIDP) .

HY-P10379

palm-PrRP31	Neuropeptide FF Receptor	Others Neurological Disease
palm-PrRP31 is a potent dual receptor agonist for both GPR10 (EC₅₀=72 pM) and NPFF-R2. palm-PrRP31 activates downstream signaling pathways through binding to its receptors, GPR10 and NPFF-R2, which results in reduced appetite and increased energy expenditure. Utilizing palm-PrRP31 facilitates the study of the mechanism of action in the nervous system, thereby elucidating the complex biological processes that regulate appetite and energy expenditure .

HY-P10380

palm11-PrRP31	Neuropeptide FF Receptor	Neurological Disease
palm11-PrRP31 is a lipidized endogenous appetite inhibitory neuropeptide (PrRP) analogue. palm11-PrRP31 is GPR10 (EC₅₀=39 pM) and NPFF-R2 effective dual agonists. palm11-PrRP31 is able to mimic the natural function of PrRP by binding to these receptors to reduce food intake. palm11-PrRP31 can be used as a potential anti-obesity agent and for the study of neuropeptide-receptor interaction .

HY-P5954

PLTX-II	Peptides	Others
PLTX-II is a calcium channel blocker. PLTX-II has a 44-residue peptide containing ten Cys residues and an O-palmitoylated threonine amide at the carboxy-terminus .

HY-P10381

palm11-TTDS-PrRP31	Peptides	Others
palm11-TTDS-PrRP31 is a strong agonist of GPR10 (EC₅₀: 84 pM). palm11-TTDS-PrRP31 has long-lasting anorexigenic effects .

HY-P10031

SAR441255	GLP Receptor GCGR	Metabolic Disease
SAR441255 is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. SAR441255 displays high potency with balanced activation of all three target receptors.?SAR441255 shows positive acute glucoregulatory effectss in diabetic obese monkeys .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-154922

Palmitoyl coenzyme A Palmitoyl CoA	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Palmitoyl coenzyme A is an acyl-CoA thioester that can be transported into the mitochondrial matrix via the carnitine shuttle system and is involved in β-oxidation. Palmitoyl coenzyme A can also be used as a substrate for sphingosine biosynthesis .

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Palmitoyl CoA

Inhibitors & Agonists

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