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Results for "

TAZ

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Hippo (MST) (2) LPL Receptor (1) Myosin (1) YAP (21)
By Research Areas:	Cancer (20) Cardiovascular Disease (1) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (1)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-125016

TT-10 1 Publications Verification TAZ-K	YAP	Cardiovascular Disease Cancer
TT-10 (TAZ-K) is an activator of YES-associated protein (YAP)-transcriptional enhancer factor domain (TEAD) activity. TT-10 can be used for the research of heart diseases accompanied by cardiomyocyte loss .

HY-147322

*YAP/TAZ* inhibitor-2**	YAP	Cancer
YAP/TAZ inhibitor-2 is a potent and orally active *TEAD-YAP/TAZ* inhibitor with an EC₅₀ value of 3 nM. YAP/TAZ inhibitor-2 shows anti-proliferative activity. YAP/TAZ inhibitor-2 shows antitumor activity .

HY-400902

*YAP/TAZ* inhibitor-3**	YAP	Cancer
YAP/TAZ inhibitor-3 (Compound 24) is a *YAP/TAZ* inhibitor. YAP/TAZ inhibitor-3 shows firefly luciferase inhibitory activity, with an IC₅₀ < 0.1 μM .

HY-111429

*YAP/TAZ* inhibitor-1** 5+ Cited Publications	YAP	Cancer
YAP/TAZ inhibitor-1 is a *YAP/TAZ* inhibitor extracted from patent WO2017058716A1, Compound 1, has an IC₅₀ of <0.100 μΜ in firefly luciferase assay .

HY-134955

VT103 2 Publications Verification	YAP	Cancer
VT103, an analog of VT101, is an orally active and selective TEAD1 protein palmitoylation inhibitor. VT103 inhibits *YAP/TAZ-TEAD* promoted gene transcription, blocks TEAD auto-palmitoylation, and disrupts interaction between *YAP/TAZ* and TEAD. VT103 can be used for the research of cancer .

HY-138565

K-975 10+ Cited Publications	YAP	Cancer
K-975 is a potent, selective and orally active TEAD inhibitor, with a strong inhibitory effect against protein-protein interactions between *YAP1/TAZ* and TEAD. K-975 covalently binds to Cys359 located in the palmitate-binding pocket of TEAD via an acrylamide structure. K-975 exhibits antitumor activity on malignant pleural mesothelioma .

HY-161573

BAY-593	YAP	Cancer
BAY-593 is an orally active GGTase-I inhibitor. BAY-593 has anti-tumor activity and blocks YAP1/TAZ signaling in vivo .

HY-169316

*YAP/TAZ* inhibitor-4**	YAP	Cancer
YAP/TAZ inhibitor-4 (Compound 45) is an inhibitor of *YAP/TAZ, exhibiting TEAD* transcriptional activation inhibitory activity by suppressing the binding of YAP or *TAZ* to TEAD .

HY-W1005067

EN171	Others	Others
EN171 is a covalent ligand that covalently targets both C38 and C96 on 14-3-3 to enhance 14-3-3 interactions with ERα, YAP and TAZ, leading to impaired estrogen receptor and Hippo pathway transcriptional activity. EN171 can not only be used as a molecular glue to enhance native protein interactions but can also be used as a covalent 14-3-3 recruiter in heterobifunctional molecules to sequester nuclear neo-substrates such as BRD4 and BLC6 into the cytosol .

HY-162838

TCF199	Others	Others
TCF199 is an allosteric stabilizer that stabilizes the 14-3-3/TAZ peptide interaction, binding to the 14-3-3ζ/E R α peptide and 14-3-3ζ/Chibby peptide. TCF199 has a Kd value of 122 μM for its interaction with 14-3-3/TAZ .

HY-156024

TEAD-IN-6	YAP	Others
TEAD-IN-6 (Example 11-1) is a TEAD modulator that blocks the interaction between *YAP1/TAZ* and TEAD. TEAD-IN-6 can be used in cancer research .

HY-112821

IBS008738	YAP	Inflammation/Immunology
IBS008738 is a potent *TAZ* activator. IBS008738 stabilizes TAZ, increases the unphosphorylated TAZ level, enhances the association of MyoD with the myogenin promoter, upregulates MyoD-dependent gene transcription, and competes with myostatin in C2C12 cells. IBS008738 enhances myogenesis in C2C12 cells and facilitates muscle repair in a muscle injury model .

HY-155338

SWTX-143	YAP	Cancer
SWTX-143 is an orally active *YAP*/TAZ-TEAD inhibitor that binds to the palmitoylation pocket of all four TEAD isoforms. SWTX-143 causes irreversible and specific inhibition of the transcriptional activity of YAP/TAZ-TEAD and shows antitumor activity .

HY-161573A

(7S)-BAY-593	YAP	Cancer
(7S)-BAY-593 is the S-enantiomer of BAY-593 (HY-161573). BAY-593 is an orally active GGTase-I inhibitor. BAY-593 has anti-tumor activity and blocks YAP1/TAZ signaling in vivo .

HY-112920

TM-25659	Others	Metabolic Disease
TM-25659 is a transcriptional co-activator with PDZ-binding motif (TAZ) modulator. Anti-osteoporotic and anti-obesity activities .

HY-15417

ML-7 hydrochloride Maximum Cited Publications 21 Publications Verification	Myosin YAP	Cancer
ML-7 hydrochloride is a naphthalene sulphonamide derivative, potently inhibits MLCK (IC₅₀=300 nM). ML-7 hydrochloride also inhibits *YAP/TAZ*.

HY-147214

GNE-7883	YAP	Cancer
GNE-7883 is a pan-TEAD inhibitor that blocks the association of *YAP/TAZ* with TEAD. GNE-7883 effectively reduces chromatin accessibility at TEAD motifs, inhibits cell proliferation in multiple cell line models, and achieves strong anti-tumor efficacy in vivo. In addition, GNE-7883 effectively overcomes intrinsic and acquired resistance to KRAS (Kirsten rat sarcoma viral oncogene homolog) G12C inhibitors in multiple preclinical models by inhibiting *YAP/TAZ* activation .

HY-134956

VT104	YAP	Cancer
VT104 is a potent and orally active *YAP/TAZ* inhibitor. VT104 prevents palmitoylation of endogenous TEAD1 and TEAD3 proteins. VT104 can be used in research of cancer .

HY-147208

MSC-4106	YAP	Cancer
MSC-4106 is an orally active and potent inhibitor of *YAP/TAZ-TEAD. MSC-4106 inhibits TEAD1* or TEAD3 auto-palmitoylation and shows inhibitory effect on NCI-H226 tumor xenograft model .

HY-153811

IAG933 YAP-TEAD-IN-3	YAP Apoptosis	Cancer
IAG933 (YAP-TEAD-IN-3) is an orally available *YAP/TAZ-TEAD* inhibitor that has anti-tumor effects and promotes apoptosis. IAG933 YAP-TEAD-IN-3 inhibits Avi-human TEAD ^4217-434, with an IC₅₀ value of 9 nM .

HY-N8847

α-Ionone alpha-Ionone	Hippo (MST) YAP	Cancer
α-Ionone (alpha-Ionone) is an activator of the olfactory receptor OR10A6. α-Ionone induces apoptosis by activating OR10A6 and increasing the phosphorylation of the *LATS-YAP-TAZ* signaling axis in the Hippo pathway. α-Ionone can inhibit tumor formation both in vivo and in vitro .

HY-147165

VT02956	YAP	Cancer
VT02956 is a LATS inhibitor (IC₅₀: 0.76 nM for LATS1, 0.52 nM for LATS2). VT02956 targets the Hippo pathway. VT02956 inhibits ESR1 expression and growth of ER+ breast cancer cell lines and patient-derived tumor organoids . VT02956 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N8847R

α-Ionone (Standard)	Hippo (MST) YAP	Cancer
α-Ionone (Standard) is the analytical standard of α-Ionone. This product is intended for research and analytical applications. α-Ionone (alpha-Ionone) is an activator of the olfactory receptor OR10A6. α-Ionone induces apoptosis by activating OR10A6 and increasing the phosphorylation of the LATS-YAP-TAZ signaling axis in the Hippo pathway. α-Ionone can inhibit tumor formation both in vivo and in vitro .

HY-13285

Ki16425 5+ Cited Publications Debio 0719	LPL Receptor	Neurological Disease Cancer
Ki16425 (Debio 0719) is a subtype-selective, competitive antagonist of the EDG-family receptors, LPA1 and LPA3 with K_is of 0.34 μM and 0.93 μM, respectively. Ki16425 (Debio 0719) reduces the LPA-induced activation of p42/p44 MAPK . Ki16425 can also inhibit LPA-induced dephosphorylation of Yes-associated protein (YAP)/TAZ in HEK293A cells .

HY-147082

GA-017 1 Publications Verification	YAP	Cancer
GA-017 is a potent and selective LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor, with IC₅₀ values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes *YAP/TAZ* activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N8847

α-Ionone alpha-Ionone	Source classification Asteraceae Sonchus erzincanicusV.A.Matthews Plants	Hippo (MST) YAP
α-Ionone (alpha-Ionone) is an activator of the olfactory receptor OR10A6. α-Ionone induces apoptosis by activating OR10A6 and increasing the phosphorylation of the *LATS-YAP-TAZ* signaling axis in the Hippo pathway. α-Ionone can inhibit tumor formation both in vivo and in vitro .

HY-N8847R

α-Ionone (Standard)	Source classification Asteraceae Sonchus erzincanicusV.A.Matthews Plants	Hippo (MST) YAP
α-Ionone (Standard) is the analytical standard of α-Ionone. This product is intended for research and analytical applications. α-Ionone (alpha-Ionone) is an activator of the olfactory receptor OR10A6. α-Ionone induces apoptosis by activating OR10A6 and increasing the phosphorylation of the LATS-YAP-TAZ signaling axis in the Hippo pathway. α-Ionone can inhibit tumor formation both in vivo and in vitro .

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TAZ

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