2. Stem Cell/Wnt
  3. YAP
  4. (7S)-BAY-593

(7S)-BAY-593 is the S-enantiomer of BAY-593 (HY-161573). BAY-593 is an orally active GGTase-I inhibitor. BAY-593 has anti-tumor activity and blocks YAP1/TAZ signaling in vivo.

For research use only. We do not sell to patients.

(7S)-BAY-593 Chemical Structure

(7S)-BAY-593 Chemical Structure

CAS No. : 2413068-25-2

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5 mg USD 550 In-stock
10 mg USD 880 In-stock
25 mg USD 1760 In-stock
50 mg USD 2800 In-stock
100 mg USD 4450 In-stock
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(7S)-BAY-593 Related Antibodies

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Description

(7S)-BAY-593 is the S-enantiomer of BAY-593 (HY-161573). BAY-593 is an orally active GGTase-I inhibitor. BAY-593 has anti-tumor activity and blocks YAP1/TAZ signaling in vivo[1].

Molecular Weight

476.53

Formula

C26H31F3N2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CCC2(CCNC[C@]2([H])C3=CC=CC=C3OC)CC1)[C@@](OC)(C(F)(F)F)C4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (262.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0985 mL 10.4925 mL 20.9850 mL
5 mM 0.4197 mL 2.0985 mL 4.1970 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0985 mL 10.4925 mL 20.9850 mL 52.4626 mL
5 mM 0.4197 mL 2.0985 mL 4.1970 mL 10.4925 mL
10 mM 0.2099 mL 1.0493 mL 2.0985 mL 5.2463 mL
15 mM 0.1399 mL 0.6995 mL 1.3990 mL 3.4975 mL
20 mM 0.1049 mL 0.5246 mL 1.0493 mL 2.6231 mL
25 mM 0.0839 mL 0.4197 mL 0.8394 mL 2.0985 mL
30 mM 0.0700 mL 0.3498 mL 0.6995 mL 1.7488 mL
40 mM 0.0525 mL 0.2623 mL 0.5246 mL 1.3116 mL
50 mM 0.0420 mL 0.2099 mL 0.4197 mL 1.0493 mL
60 mM 0.0350 mL 0.1749 mL 0.3498 mL 0.8744 mL
80 mM 0.0262 mL 0.1312 mL 0.2623 mL 0.6558 mL
100 mM 0.0210 mL 0.1049 mL 0.2099 mL 0.5246 mL
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(7S)-BAY-593 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(7S)-BAY-5932413068-25-2YAPYes-associated proteinS-enantiomerorally activeInhibitorinhibitorinhibit

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