YAP/TAZ inhibitor-3

Cat. No.: HY-400902 Purity: 99.30%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

YAP/TAZ inhibitor-3 (Compound 24) is a YAP/TAZ inhibitor. YAP/TAZ inhibitor-3 shows firefly luciferase inhibitory activity, with an IC₅₀ < 0.1 μM.

For research use only. We do not sell to patients.

YAP/TAZ inhibitor-3 Chemical Structure

CAS No. : 2506273-81-8

Size	Price	Stock	Quantity
5 mg	USD 290	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 465	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 935	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1500	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2400	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

YAP/TAZ inhibitor-3 (Compound 24) is a YAP/TAZ inhibitor. YAP/TAZ inhibitor-3 shows firefly luciferase inhibitory activity, with an IC₅₀ < 0.1 μM^[1].

Molecular Weight

389.37

Formula

C₂₁H₁₈F₃NO₃

CAS No.

2506273-81-8

Appearance

Solid

Color

White to off-white

SMILES

OC[C@@H](C)NC(C(C=C1)=CC2=C1C(OC3=CC=C(C=C3)C(F)(F)F)=CC=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 125 mg/mL (321.03 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5683 mL	12.8413 mL	25.6825 mL
5 mM	0.5137 mL	2.5683 mL	5.1365 mL
10 mM	0.2568 mL	1.2841 mL	2.5683 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.30%

Select Batch:

Data Sheet (267 KB) SDS (251 KB)

COA (246 KB) HNMR (273 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Andrei W. Konradi, et al. Bicyclic compounds. Patent, WO2020214734A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5683 mL	12.8413 mL	25.6825 mL	64.2063 mL
	5 mM	0.5137 mL	2.5683 mL	5.1365 mL	12.8413 mL
	10 mM	0.2568 mL	1.2841 mL	2.5683 mL	6.4206 mL
	15 mM	0.1712 mL	0.8561 mL	1.7122 mL	4.2804 mL
	20 mM	0.1284 mL	0.6421 mL	1.2841 mL	3.2103 mL
	25 mM	0.1027 mL	0.5137 mL	1.0273 mL	2.5683 mL
	30 mM	0.0856 mL	0.4280 mL	0.8561 mL	2.1402 mL
	40 mM	0.0642 mL	0.3210 mL	0.6421 mL	1.6052 mL
	50 mM	0.0514 mL	0.2568 mL	0.5137 mL	1.2841 mL
	60 mM	0.0428 mL	0.2140 mL	0.4280 mL	1.0701 mL
	80 mM	0.0321 mL	0.1605 mL	0.3210 mL	0.8026 mL
	100 mM	0.0257 mL	0.1284 mL	0.2568 mL	0.6421 mL