2. Stem Cell/Wnt
  3. YAP
  4. YAP/TAZ inhibitor-2

YAP/TAZ inhibitor-2 is a potent and orally active TEAD-YAP/TAZ inhibitor with an EC50 value of 3 nM. YAP/TAZ inhibitor-2 shows anti-proliferative activity. YAP/TAZ inhibitor-2 shows antitumor activity.

For research use only. We do not sell to patients.

YAP/TAZ inhibitor-2 Chemical Structure

YAP/TAZ inhibitor-2 Chemical Structure

CAS No. : 2762617-31-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 275 In-stock
Solution
10 mM * 1 mL in DMSO USD 275 In-stock
Solid
5 mg USD 250 In-stock
10 mg USD 380 In-stock
25 mg USD 650 In-stock
50 mg USD 950 In-stock
100 mg USD 1375 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

YAP/TAZ inhibitor-2 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

YAP/TAZ inhibitor-2 is a potent and orally active TEAD-YAP/TAZ inhibitor with an EC50 value of 3 nM. YAP/TAZ inhibitor-2 shows anti-proliferative activity. YAP/TAZ inhibitor-2 shows antitumor activity[1].

IC50 & Target

EC50: 3 nM (TEAD-YAP/TAZ)[1]
In Vitro

YAP/TAZ inhibitor-2 (compound 5) (0-20000 nM; 24 h) shows antiproliferative activity with an IC50 value of 5.33 nM in NCI-H226 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

YAP/TAZ inhibitor-2 Related Antibodies
In Vivo

YAP/TAZ inhibitor-2 (0.5, 2, 5, 50 mg/kg; p.o.; daily for 28 days) shows anti-tumor activity with no significant body weight loss during the treatment in BALB/c nude mice (NCI-H226 xenograft model)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

390.33

Formula

C19H14F4N4O
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

C=C(F)C(N1CC(N2N=C(C3=CC=C(C(F)(F)F)C=C3)C4=CC=CN=C42)C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (256.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5619 mL 12.8097 mL 25.6193 mL
5 mM 0.5124 mL 2.5619 mL 5.1239 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5619 mL 12.8097 mL 25.6193 mL 64.0484 mL
5 mM 0.5124 mL 2.5619 mL 5.1239 mL 12.8097 mL
10 mM 0.2562 mL 1.2810 mL 2.5619 mL 6.4048 mL
15 mM 0.1708 mL 0.8540 mL 1.7080 mL 4.2699 mL
20 mM 0.1281 mL 0.6405 mL 1.2810 mL 3.2024 mL
25 mM 0.1025 mL 0.5124 mL 1.0248 mL 2.5619 mL
30 mM 0.0854 mL 0.4270 mL 0.8540 mL 2.1349 mL
40 mM 0.0640 mL 0.3202 mL 0.6405 mL 1.6012 mL
50 mM 0.0512 mL 0.2562 mL 0.5124 mL 1.2810 mL
60 mM 0.0427 mL 0.2135 mL 0.4270 mL 1.0675 mL
80 mM 0.0320 mL 0.1601 mL 0.3202 mL 0.8006 mL
100 mM 0.0256 mL 0.1281 mL 0.2562 mL 0.6405 mL
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YAP/TAZ inhibitor-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YAP/TAZ inhibitor-22762617-31-0YAPYes-associated proteinH2052 cellsNCI-H226 cellsantiproliferativeanti-tumornude mice,orally activeInhibitorinhibitorinhibit

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