2. Stem Cell/Wnt
  3. YAP
  4. VT104

VT104 is a potent and orally active YAP/TAZ inhibitor. VT104 prevents palmitoylation of endogenous TEAD1 and TEAD3 proteins. VT104 can be used in research of cancer.

For research use only. We do not sell to patients.

VT104 Chemical Structure

VT104 Chemical Structure

CAS No. : 2417718-25-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 287 In-stock
Solution
10 mM * 1 mL in DMSO USD 287 In-stock
Solid
1 mg USD 90 In-stock
5 mg USD 310 In-stock
10 mg USD 503 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of VT104:

VT104 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

VT104 is a potent and orally active YAP/TAZ inhibitor. VT104 prevents palmitoylation of endogenous TEAD1 and TEAD3 proteins. VT104 can be used in research of cancer[1][2].

Cellular Effect
Cell Line Type Value Description References
NCI-H226 IC50
0.042 μM
Compound: VT-104
Cytotoxicity against human NCI-H226 cells assessed as cell viability at 10 uM measured for 7 days by celltiter-glo assay
Cytotoxicity against human NCI-H226 cells assessed as cell viability at 10 uM measured for 7 days by celltiter-glo assay
[PMID: 35763499]
In Vitro

VT104 (0-1000 nM) inhibits proliferation of NF2 mutant/defective cell line[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VT104 Related Antibodies
In Vivo

VT104 (0.3-3 mg/kg; p.o.; NCI-H226-tumor bearing mice) blocks growth of NF2-deficient mesothelioma xenografts[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NCI-H226-tumor bearing mice[1]
Dosage: 0.3, 1, and 3 mg/kg
Administration: Oral administration
Result: Blocked NCI-H226 tumor growth in mice in dose-dependent manner.
Molecular Weight

420.43

Formula

C25H19F3N2O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C2C(C3=CC=C(C(F)(F)F)C=C3)=CC=CC2=C1)N[C@H](C4=NC=CC=C4)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (237.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3785 mL 11.8926 mL 23.7852 mL
5 mM 0.4757 mL 2.3785 mL 4.7570 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.94%

SDS (252 KB)

COA (252 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3785 mL 11.8926 mL 23.7852 mL 59.4629 mL
5 mM 0.4757 mL 2.3785 mL 4.7570 mL 11.8926 mL
10 mM 0.2379 mL 1.1893 mL 2.3785 mL 5.9463 mL
15 mM 0.1586 mL 0.7928 mL 1.5857 mL 3.9642 mL
20 mM 0.1189 mL 0.5946 mL 1.1893 mL 2.9731 mL
25 mM 0.0951 mL 0.4757 mL 0.9514 mL 2.3785 mL
30 mM 0.0793 mL 0.3964 mL 0.7928 mL 1.9821 mL
40 mM 0.0595 mL 0.2973 mL 0.5946 mL 1.4866 mL
50 mM 0.0476 mL 0.2379 mL 0.4757 mL 1.1893 mL
60 mM 0.0396 mL 0.1982 mL 0.3964 mL 0.9910 mL
80 mM 0.0297 mL 0.1487 mL 0.2973 mL 0.7433 mL
100 mM 0.0238 mL 0.1189 mL 0.2379 mL 0.5946 mL
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VT104 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VT1042417718-25-1VT 104VT-104YAPYes-associated proteinTEAD1TEAD3palmitoylationcancarInhibitorinhibitorinhibit

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