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Triterpene Saponins

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (1) AMPK (1) Apoptosis (1) Autophagy (1) Bacterial (2) Biochemical Assay Reagents (1) COX (2) Estrogen Receptor/ERR (2) HIV Protease (2) NF-κB (5) NO Synthase (1) PPAR (2) STAT (2) Xanthine Oxidase (1)
By Research Areas:	Cancer (9) Cardiovascular Disease (2) Infection (4) Inflammation/Immunology (9) Metabolic Disease (4) Neurological Disease (2)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N7952

Achyranthoside D	Others	Others
Achyranthoside D is a triterpene saponin from Achyranthes root .

HY-N11923

Lysimachigenoside C	Others	Others
Lysimachigenoside C is a triterpene saponin isolated from Lysimachia foenum-graecum Hance .

HY-N4217

Saikosaponin I	Others	Others
Saikosaponin I is a triterpene saponin extracted from Bupleurum falcatum L. Saikosaponin can be used to treat fever, inflammation, liver disease, and nephritis .

HY-125686

Beesioside Q	Others	Others
Beesioside Q is a oleanolic acid triterpene saponin isolated from the rhizome of Beesia calthaefolia (Maxim.) Ulbr .

HY-N12190

Centellasaponin A	Others	Others
Centellasaponin A (compound 10) is a pentacyclic triterpene saponin isolated from the methanolic extract of Centella asiatica .

HY-N11034

24-Hydroxy-licorice-saponin A3	Others	Others
24-Hydroxy-licorice-saponin A3 is an oleanane-type triterpene saponin (OTS). 24-Hydroxy-licorice-saponin A3 can be isolated from G. uralensis. .

HY-N8098

Pulchinenoside E2	Others	Cancer
Pulchinenoside E2 (Compound 8) is a triterpene saponin isolated from the roots of Pulsatilla chinensis. Pulchinenoside E2 shows cytotoxic to HL-60 cells with an IC₅₀ value of 2.6 µg/mL .

HY-N8763

Ciwujianoside E Guaianin A	Others	Neurological Disease
Ciwujianoside E is a triterpene saponin that can be isolated from Acanthopanax senticosus. Ciwujianoside E can be used in study sedative-hypnotic drug .

HY-N9324

Ilexoside O	Xanthine Oxidase	Inflammation/Immunology
Ilexoside O is a triterpene saponin isolated from the roots of Ilex pubescens. Ilexoside O exhibits weak xanthine oxidase (XOD) inhibitory activity (IC₅₀=53.05 μM) .

HY-N12225

Isoasiaticoside	Others	Neurological Disease
Isoasiaticoside is a pentacyclic triterpene saponin that can be isolated from Centella asiatica. Isoasiaticoside has potential neuroprotective effects in the 6-OHDA (HY-B1081)-induced PC12 cell model .

HY-N7687

Caulophyllogenin	PPAR	Metabolic Disease Inflammation/Immunology
Caulophyllogenin is a triterpene saponin extracted from M. polimorpha. Caulophyllogenin is a partial PPARγ agonist, with an EC₅₀ of 12.6 μM. Caulophyllogenin can be used for the research of type-2 diabetes, obesity, metabolic syndrome and inflammation .

HY-N0302

Gypsoside	Others	Cardiovascular Disease
Gypenoside is a triterpene saponin from gypsophila paniculata L .

HY-N7235

Lanatoside E	Others	Cancer
Lanatoside E is a cyclic triterpene saponin with antitumor activity .

HY-N11810

Polyfuroside	Others	Others
Polyfuroside is a triterpenoid saponin, which can be isolated from the defatted rhizome of jade bamboo .

HY-125121

Esculentoside C	Biochemical Assay Reagents	Others
Esculentoside C is a triterpene saponin. Esculentoside C can be obtained from the root of Phytolacca esculenta .

HY-N6911B

Licorice-saponin H2 ammonium (18β,20α)-Glycyrrhizic acid ammonium	Others	Others
Licorice-saponin H2 ammonium (compound 7) is a type of oleanolic acid triterpene glycoside that can be isolated from the roots of licorice .

HY-N2541

Gymnemic acid I	Apoptosis Autophagy	Metabolic Disease
Gymnemic acid I is a bioactive triterpene saponin found in Gymnema sylvestre. Gymnemic acid I decreases the apoptosis under the high glucose stress .

HY-N9328

Tarasaponin IV	Others	Cancer
Tarasaponin IV, as an oleanane-type triterpene saponin, is isolated from the bark of Aralia elata. Tarasaponin IV can be used for the research of cancer .

HY-N9402

Prosaikogenin A	Others	Cardiovascular Disease
Prosaikogenin A is a triterpene saponin isolated from Clinopodium chinense. Prosaikogenin A has significant promoting effects on platelet aggregation with an EC₅₀ value of 12.2 μM .

HY-N9524

Ilexoside XLVIII	Acyltransferase	Metabolic Disease
Ilexoside XLVIII is an acyl CoA cholesteryl acyl transferase (ACAT) inhibitor. Ilexoside XLVIII is a triterpene saponin isolated from an aqueous extract of the leaves of Ilex kudincha .

HY-N7616

Oleanolic acid-3-O-glucosyl(1-2)xylyl(1-3)glucosiduronic acid	Others	Others
Oleanolic acid-3-O-glucosyl(1-2)xylyl(1-3)glucosiduronic acid is a nature occurring triterpene saponin .

HY-N2138

Buddlejasaponin IVb	Others	Inflammation/Immunology
Buddlejasaponin IVb (Compound 2), a triterpene saponin isolated from Clinopodium chinense (Benth.) O. Kuntze, Compound 2 has hemostasis efficacy, shortens thrombin time (TT) by 20.6 % .

HY-N1404

Sodium aescinate	NF-κB	Inflammation/Immunology Cancer
Sodium aescinate is a triterpene saponin derived from Aesculus hippocastanum seeds, with anti-inflammatory and antioxidant activities . Sodium aescinate inhibits hepatocellular carcinoma growth by targeting CARMA3/NF-κB pathway .

HY-N0250

Saikosaponin D 3 Publications Verification	STAT NF-κB Estrogen Receptor/ERR Bacterial	Infection Inflammation/Immunology Cancer
Saikosaponin D is a triterpene saponin isolated from Bupleurum, with anti-inflammatory, anti-bacterial, anti-tumor, and anti-allergic activities; Saikosaponin D inhibits selectin, STAT3 and NF-kB and activates estrogen receptor-β.

HY-N6252

Gypenoside XLVI 1 Publications Verification	Others	Cancer
Gypenoside XLVI is one of the major dammarane-type triterpenoid saponins from Gynostamma pentaphallum . Gypenoside XLVI has a tetracyclic triterpene structure and possess potent non-small cell lung carcinoma A549 cell inhibitory activity .

HY-N7497

Protoescigenin	Others	Others
Protoescigenin is the main aglycone of horse chestnut saponin mixture known as escin. Protoescigenin is selected as substrate for exploratory chemistry towards selective protection, followed by propargyl ether formation and subsequent condensation with azido-monosaccharides, to obtain novel triazole linked conjugates of the triterpene .

HY-N11924

Foenumoside B	AMPK PPAR	Metabolic Disease
Foenumoside B is a triterpene saponin isolated from Lysimachia foenum-graecum. Foenumoside B activates AMPK signaling, inhibits PPARγ-induced adipogenesis, and shifts lipid metabolism toward lipolysis. Foenumoside B can be used in the study of obesity and obesity-related metabolic diseases .

HY-N0554

Escin IA	HIV Protease	Infection Cancer
Escin IA is a triterpene saponin isolated from Aesculus hippocastanum, which inhibits HIV-1 protease with IC₅₀ values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved inhibition of epithelial-mesenchymal transition process by down-regulating LOXL2 expression .

HY-N0250R

Saikosaponin D (Standard)	STAT NF-κB Estrogen Receptor/ERR Bacterial	Infection Inflammation/Immunology Cancer
Saikosaponin D (Standard) is the analytical standard of Saikosaponin D. This product is intended for research and analytical applications. Saikosaponin D is a triterpene saponin isolated from Bupleurum, with anti-inflammatory, anti-bacterial, anti-tumor, and anti-allergic activities; Saikosaponin D inhibits selectin, STAT3 and NF-kB and activates estrogen receptor-β.

HY-N7497R

Protoescigenin (Standard)	Others	Others
Protoescigenin (Standard) is the analytical standard of Protoescigenin. This product is intended for research and analytical applications. Protoescigenin is the main aglycone of horse chestnut saponin mixture known as escin. Protoescigenin is selected as substrate for exploratory chemistry towards selective protection, followed by propargyl ether formation and subsequent condensation with azido-monosaccharides, to obtain novel triazole linked conjugates of the triterpene .

HY-N0554R

Escin IA (Standard)	HIV Protease	Infection Cancer
Escin IA (Standard) is the analytical standard of Escin IA. This product is intended for research and analytical applications. Escin IA is a triterpene saponin isolated from Aesculus hippocastanum, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved inhibition of epithelial-mesenchymal transition process by down-regulating LOXL2 expression .

HY-N0632

Esculentoside A 2 Publications Verification	COX NF-κB	Inflammation/Immunology
Esculentoside A (EsA), a kind of triterpene saponin isolated from roots of Phytolacca esculenta . Esculentoside A (EsA) possesses anti-inflammatory activity in acute and chronic experimental models , has selective inhibitory activity towards cyclooxygenase-2 (COX-2) . Esculentoside A (EsA) suppresses inflammatory responses in LPS-induced acute lung injury (ALI) through inhibition of the nuclear factor kappa B (NF-ΚB) and mitogen activated protein kinase (MAPK) signaling pathways .

HY-N0632R

Esculentoside A (Standard)	COX NF-κB	Inflammation/Immunology
Esculentoside A (Standard) is the analytical standard of Esculentoside A. This product is intended for research and analytical applications. Esculentoside A (EsA), a kind of triterpene saponin isolated from roots of Phytolacca esculenta . Esculentoside A (EsA) possesses anti-inflammatory activity in acute and chronic experimental models , has selective inhibitory activity towards cyclooxygenase-2 (COX-2) . Esculentoside A (EsA) suppresses inflammatory responses in LPS-induced acute lung injury (ALI) through inhibition of the nuclear factor kappa B (NF-ΚB) and mitogen activated protein kinase (MAPK) signaling pathways .

HY-N13138

Angulasaponin B	NO Synthase	Inflammation/Immunology
Angulasaponin B, a natural product, can be obtained from Vigna angularis. Angulasaponin B inhibits nitric oxide production in LPS-activated RAW264.7 macrophages with IC₅₀ values ranging from 13 μM to 24 μM .

Achyranthoside D	Triterpenes Classification of Application Fields Terpenoids Source classification Other Diseases Amaranthaceae Plants Disease Research Fields Achyranthes	Others
Achyranthoside D is a triterpene saponin from Achyranthes root .

Lysimachigenoside C	Triterpenes Structural Classification Terpenoids Source classification Lysimachia foenum-graecum Hance Plants Primulaceae	Others
Lysimachigenoside C is a triterpene saponin isolated from Lysimachia foenum-graecum Hance .

Saikosaponin I	Triterpenes Structural Classification Terpenoids Source classification Launaea mucronata (Forssk.) Muschl. Plants Umbelliferae	Others
Saikosaponin I is a triterpene saponin extracted from Bupleurum falcatum L. Saikosaponin can be used to treat fever, inflammation, liver disease, and nephritis .

Beesioside Q	Triterpenes Classification of Application Fields Terpenoids Source classification Ranunculaceae Other Diseases Plants Disease Research Fields Pulsatilla chinensis (Bunge) Regel	Others
Beesioside Q is a oleanolic acid triterpene saponin isolated from the rhizome of Beesia calthaefolia (Maxim.) Ulbr .

Centellasaponin A	Triterpenes Structural Classification Polysaccharides Terpenoids Source classification Tagetes lucida Cav. Plants Umbelliferae Saccharides	Others
Centellasaponin A (compound 10) is a pentacyclic triterpene saponin isolated from the methanolic extract of Centella asiatica .

24-Hydroxy-licorice-saponin A3	Triterpenes Structural Classification Leguminosae Terpenoids Source classification Plants Glycyrrhiza uralensis Fisch.	Others
24-Hydroxy-licorice-saponin A3 is an oleanane-type triterpene saponin (OTS). 24-Hydroxy-licorice-saponin A3 can be isolated from G. uralensis. .

Pulchinenoside E2	Triterpenes Classification of Application Fields Terpenoids Source classification Ranunculaceae Plants Disease Research Fields Pulsatilla chinensis (Bunge) Regel Cancer	Others
Pulchinenoside E2 (Compound 8) is a triterpene saponin isolated from the roots of Pulsatilla chinensis. Pulchinenoside E2 shows cytotoxic to HL-60 cells with an IC₅₀ value of 2.6 µg/mL .

Ciwujianoside E Guaianin A	Structural Classification Polysaccharides Ketones, Aldehydes, Acids Source classification Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Saccharides Araliaceae	Others
Ciwujianoside E is a triterpene saponin that can be isolated from Acanthopanax senticosus. Ciwujianoside E can be used in study sedative-hypnotic drug .

Ilexoside O	Aquifoliaceae Triterpenes Classification of Application Fields Terpenoids Source classification Ilex pubescens Hook. et Arn. Plants Disease Research Fields Inflammation/Immunology	Xanthine Oxidase
Ilexoside O is a triterpene saponin isolated from the roots of Ilex pubescens. Ilexoside O exhibits weak xanthine oxidase (XOD) inhibitory activity (IC₅₀=53.05 μM) .

Isoasiaticoside	Triterpenes Structural Classification Polysaccharides Terpenoids Source classification Tagetes lucida Cav. Plants Umbelliferae Saccharides	Others
Isoasiaticoside is a pentacyclic triterpene saponin that can be isolated from Centella asiatica. Isoasiaticoside has potential neuroprotective effects in the 6-OHDA (HY-B1081)-induced PC12 cell model .

Caulophyllogenin	Triterpenes Classification of Application Fields Leguminosae Terpenoids Source classification Acacia catechu (Linn. f.) Willd. Plants Disease Research Fields Inflammation/Immunology	PPAR
Caulophyllogenin is a triterpene saponin extracted from M. polimorpha. Caulophyllogenin is a partial PPARγ agonist, with an EC₅₀ of 12.6 μM. Caulophyllogenin can be used for the research of type-2 diabetes, obesity, metabolic syndrome and inflammation .

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Triterpene Saponins

Inhibitors & Agonists

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Natural
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