hepatocyte growth factor receptor

By Targets:	VEGFR (3) Angiotensin Receptor (2) c-Met/HGFR (10) Drug-Linker Conjugates for ADC (2)
By Research Areas:	Cancer (8) Cardiovascular Disease (1) Inflammation/Immunology (1) Metabolic Disease (2) Neurological Disease (4)

Targets Recommended: FGFR GHR VEGFR TGF-beta/Smad PDGFR TGF-β Receptor GHSR EGFR IGF-1R Nuclear Hormone Receptor 4A/NR4A

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-137455

Terevalefim ANG-3777	c-Met/HGFR	Inflammation/Immunology
Terevalefim (ANG-3777), an hepatocyte growth factor (HGF) mimetic, selectively activates the c-Met receptor .

HY-156897

Val-Cit-amide-Ph-Maytansine	Drug-Linker Conjugates for ADC	Cancer
Val-Cit-amide-Ph-Maytansine is an antibody and bispecific antigen-binding mol. that bind hepatocyte growth factor receptor c-Met (MET) or antibody-drug conjugates (ADCs) .

HY-12423

Pamufetinib TAS-115	VEGFR c-Met/HGFR	Cancer
Pamufetinib (TAS-115) is a potent VEGFR and hepatocyte growth factor receptor (c-Met/HGFR)-targeted kinase inhibitor with IC₅₀s of 30 and 32 nM for rVEGFR2 and rMET, respectively.

HY-12423A

Pamufetinib mesylate TAS-115 mesylate	VEGFR c-Met/HGFR	Cancer
Pamufetinib (TAS-115) mesylate is a potent VEGFRand hepatocyte growth factor receptor (c-Met/HGFR)-targeted kinase inhibitor, with IC₅₀s of 30 and 32 nM for rVEGFR2 and rMET, respectively.

HY-156896

Val-Cit-amide-Cbz-N(Me)-Maytansine	Drug-Linker Conjugates for ADC	Cancer
Val-Cit-amide-Cbz-N(Me)-Maytansine is an antibody and bispecific antigen-binding mol. that bind hepatocyte growth factor receptor c-Met (MET) or antibody-drug conjugates (ADCs) .

HY-P1415A

Norleual TFA 1 Publications Verification	c-Met/HGFR Angiotensin Receptor	Cardiovascular Disease Neurological Disease Metabolic Disease
Norleual TFA, an angiotensin (Ang) IV analog, is a hepatocyte growth factor (HGF)/c-Met inhibitor with an IC₅₀ of 3 pM. Norleual TFA is an AT4 receptor antagonist and exhibits potent antiangiogenic activities .

HY-P99196

Ficlatuzumab	c-Met/HGFR	Cancer
Ficlatuzumab is a monoclonal antibody (McAb) targeting human hepatocyte growth factor (HGF). Ficlatuzumab blocks the activation of the HGF/c-Met signaling pathway, and inhibits c-Met receptor-mediated cancer cell proliferation, migration, and invasion .

HY-132814

Fosgonimeton ATH-1017	c-Met/HGFR	Neurological Disease
Fosgonimeton (ATH-1017) is a hepatocyte growth factor receptor (c-Met/HGFR) agonist. Fosgonimeton has neuroprotective effects in both LPS (HY-D1056) -induced neuroinflammation and Aβ-induced AD models .

HY-P1415

Norleual	c-Met/HGFR Angiotensin Receptor	Neurological Disease Metabolic Disease
Norleual, an angiotensin (Ang) IV analog, is a hepatocyte growth factor (HGF)/c-Met inhibitor with an IC₅₀ of 3 pM. Norleual is an AT4 receptor antagonist and exhibits potent antiangiogenic activities .

HY-148803

Vabametkib	c-Met/HGFR	Cancer
Vabametkib is a potent inhibitor of **hepatocyte growth factor receptor (HGFR). Vabametkib inhibits Hs746T cells proliferation and inhibits c-Met with an IC₅₀** value of 7 nM. Vabametkib can be used as an antineoplastic agent .

HY-10338A

Foretinib phosphate	c-Met/HGFR VEGFR	Cancer
Foretinib phosphate is an orally bioavailable small molecule with potential anti-tumor activity. Foretinib phosphate can selectively inhibit hepatocyte growth factor (HGF) receptor c-MET and vascular endothelial growth factor receptor 2 (VEGFR2), thereby potentially inhibiting tumor angiogenesis, tumor cell proliferation and metastasis. Foretinib phosphate shows different anti-cancer activity from cabozantinib in lung cancer cells and has stronger inhibitory effects on targets such as MEK1/2, FER and AURKB .

HY-16969

Dihexa 5 Publications Verification PNB-0408; N-hexanoic-Try-Ile-(6)-amino hexanoic amide; Hexanoyl-Tyr-Ile-Ahx-NH2	c-Met/HGFR	Neurological Disease
Dihexa, an oligopeptide drug, is an orally active and blood-brain barrier-permeable angiotensin IV analog. Dihexa binds to hepatocyte growth factor (HGF) with high affinity (K_d=65 pM) and potentiates its activity at its receptor, c-Met. Dihexa exhibits excellent antidementia activity and improves cognitive function in animal models. Dihexa may have therapeutic potential as a treatment Alzheimer’s disease .

Cat. No.	Product Name	Target	Research Area

HY-P1415A

Norleual TFA 1 Publications Verification	c-Met/HGFR Angiotensin Receptor	Cardiovascular Disease Neurological Disease Metabolic Disease
Norleual TFA, an angiotensin (Ang) IV analog, is a hepatocyte growth factor (HGF)/c-Met inhibitor with an IC₅₀ of 3 pM. Norleual TFA is an AT4 receptor antagonist and exhibits potent antiangiogenic activities .

HY-P1415

Norleual	c-Met/HGFR Angiotensin Receptor	Neurological Disease Metabolic Disease
Norleual, an angiotensin (Ang) IV analog, is a hepatocyte growth factor (HGF)/c-Met inhibitor with an IC₅₀ of 3 pM. Norleual is an AT4 receptor antagonist and exhibits potent antiangiogenic activities .

Cat. No.	Product Name	Target	Research Area

HY-P99391

Telisotuzumab ABT-700	Inhibitory Antibodies	Cancer
Telisotuzumab (ABT-700) is a human recombinant bivalent antibody, a therapeutic antibody against the hepatocyte growth factor receptor (MET) that binds c-Met with high affinity and inhibits c-Met signaling. Telisotuzumab has antitumor activity .

HY-P99196

Ficlatuzumab	c-Met/HGFR	Cancer
Ficlatuzumab is a monoclonal antibody (McAb) targeting human hepatocyte growth factor (HGF). Ficlatuzumab blocks the activation of the HGF/c-Met signaling pathway, and inhibits c-Met receptor-mediated cancer cell proliferation, migration, and invasion .

Species:	Human (5) Rhesus Macaque (3) Mouse (3) Rat (1) Cynomolgus (3) Canine (1)
Tag:	His (8) Tag Free (1) Avi (1) GST (1) Fc (4)
Source:	HEK293 (12) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P72934

	HGFR Protein, Canine (HEK293, His) hepatocyte growth factor receptor; HGF receptor; SF receptor; MET	Canine	HEK293
	The HGFR protein is a receptor tyrosine kinase that transduces signals by binding to hepatocyte growth factor/HGF. It regulates proliferation, scattering, morphogenesis, and cell survival. HGFR Protein, Canine (HEK293, His) is the recombinant canine-derived HGFR protein, expressed by HEK293 , with N-His labeled tag. The total length of HGFR Protein, Canine (HEK293, His) is 911 a.a., with molecular weight of ~35-43 kDa & 80-100 kDa, respectively.

HY-P72941

	HGFR Protein, Mouse (HEK293, His) hepatocyte growth factor receptor; HGF receptor; SF receptor; MET	Mouse	HEK293
	HGFR Protein, a receptor tyrosine kinase, transduces signals by binding hepatocyte growth factor/HGF ligand. It regulates proliferation, scattering, morphogenesis, and cell survival. Upon ligand binding, HGFR undergoes autophosphorylation, creating docking sites for downstream molecules like PI3K, PLCG1, SRC, GRB2, STAT3, or GAB1, activating RAS-ERK, PI3K-AKT, and PLCgamma-PKC cascades. HGFR Protein, Mouse (HEK293, His) is the recombinant mouse-derived HGFR protein, expressed by HEK293, with C-His labeled tag. The total length of HGFR Protein, Mouse (HEK293, His) is 905 a.a., with molecular weight of ~34-42 kDa & 79-90 kDa, respectively.

HY-P72942

	HGFR Protein, Rat (HEK293, Fc) hepatocyte growth factor receptor; HGF receptor; SF receptor; MET	Rat	HEK293
	HGFR Protein is a receptor tyrosine kinase that acts as a signal transducer of the extracellular matrix by binding to hepatocyte growth factor /HGF ligands. HGFR Protein participate in the activation of RAS-ERK, PI3 kinase-AKT, and PLCgamma-PKC signaling pathways. HGFR Protein is essential for embryonic development, organogenesis, and wound healing. HGFR Protein, Rat (HEK293, Fc) is the recombinant rat-derived HGFR protein, expressed by HEK293, with C-hFc labeled tag. The total length of HGFR Protein, Rat (HEK293, Fc) is 908 a.a., with molecular weight of ~97 & 39 kDa, respectively.

HY-P72935

	HGFR Protein, Cynomolgus/Rhesus Macaque (HEK293) hepatocyte growth factor receptor; HGF receptor; SF receptor; MET	Rhesus Macaque;Cynomolgus	HEK293
	HGFR Protein, a receptor tyrosine kinase, transduces signals by binding hepatocyte growth factor/HGF ligand. It regulates proliferation, scattering, morphogenesis, and cell survival. Upon ligand binding, HGFR undergoes autophosphorylation, creating docking sites for downstream molecules like PI3K, PLCG1, SRC, GRB2, STAT3, or GAB1, activating RAS-ERK, PI3K-AKT, and PLCgamma-PKC cascades. HGFR Protein, Cynomolgus/Rhesus Macaque (HEK293) is the recombinant Rhesus Macaque, cynomolgus-derived HGFR protein, expressed by HEK293 , with tag free.

HY-P72938

	HGFR Protein, Human (sf9, His-GST) hepatocyte growth factor receptor; HGF receptor; SF receptor; MET	Human	Sf9 insect cells
	The HGFR protein is a receptor tyrosine kinase that transduces signals by binding to hepatocyte growth factor/HGF ligand. It regulates proliferation, scattering, morphogenesis, and cell survival. HGFR Protein, Human (sf9, His-GST) is the recombinant human-derived HGFR protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P70714

	HGFR Protein, Human (HEK293, His) hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met; MET	Human	HEK293
	The HGFR protein is a receptor tyrosine kinase that transduces signals by binding to hepatocyte growth factor/HGF ligand. It regulates proliferation, scattering, morphogenesis, and cell survival. HGFR Protein, Human (HEK293, His) is the recombinant human-derived HGFR protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70715

	HGFR Protein, Human (HEK293, Fc) hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met; MET	Human	HEK293
	The HGFR protein is a receptor tyrosine kinase that transduces signals by binding to hepatocyte growth factor/HGF ligand. It regulates proliferation, scattering, morphogenesis, and cell survival. HGFR Protein, Human (HEK293, Fc) is the recombinant human-derived HGFR protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P72940

	HGFR Protein, Mouse (HEK293, Fc) hepatocyte growth factor receptor; HGF receptor; SF receptor; MET	Mouse	HEK293
	The HGFR protein is a receptor tyrosine kinase that transduces signals from the extracellular matrix by binding to hepatocyte growth factor/HGF ligand. This interaction regulates proliferation, scattering, morphogenesis, and cell survival. HGFR Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived HGFR protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P72936

	HGFR Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) hepatocyte growth factor receptor; HGF receptor; SF receptor; MET	Rhesus Macaque;Cynomolgus	HEK293
	HGFR Protein, a receptor tyrosine kinase, transduces signals by binding hepatocyte growth factor/HGF ligand. It regulates proliferation, scattering, morphogenesis, and cell survival. Upon ligand binding, HGFR undergoes autophosphorylation, creating docking sites for downstream molecules like PI3K, PLCG1, SRC, GRB2, STAT3, or GAB1, activating RAS-ERK, PI3K-AKT, and PLCgamma-PKC cascades. HGFR Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque, cynomolgus-derived HGFR protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P72937

	HGFR Protein, Cynomolgus/Rhesus Macaque (HEK293, His) hepatocyte growth factor receptor; HGF receptor; SF receptor; MET	Rhesus Macaque;Cynomolgus	HEK293
	HGFR Protein, a receptor tyrosine kinase, transduces signals by binding hepatocyte growth factor/HGF ligand. It regulates proliferation, scattering, morphogenesis, and cell survival. Upon ligand binding, HGFR undergoes autophosphorylation, creating docking sites for downstream molecules like PI3K, PLCG1, SRC, GRB2, STAT3, or GAB1, activating RAS-ERK, PI3K-AKT, and PLCgamma-PKC cascades. HGFR Protein, Cynomolgus/Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque, cynomolgus-derived HGFR protein, expressed by HEK293 , with C-His labeled tag.

HY-P72624

	HGFR Protein, Human (495a.a, HEK293, His) hepatocyte growth factor receptor; HGF receptor; SF receptor; MET	Human	HEK293
	The HGFR protein is a receptor tyrosine kinase that transduces signals by binding to hepatocyte growth factor/HGF ligand. It regulates proliferation, scattering, morphogenesis, and cell survival. HGFR Protein, Human (495a.a, HEK293, His) is the recombinant human-derived HGFR protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P72376

	HGFR Protein, Human (Biotinylated, HEK293, His-Avi) hepatocyte growth factor receptor; Proto-oncogene c-Met; SF receptor; Tyrosine-protein kinase Met; MET	Human	HEK293
	The HGFR protein is a receptor tyrosine kinase that transduces signals by binding to hepatocyte growth factor/HGF ligand. It regulates proliferation, scattering, morphogenesis, and cell survival. HGFR Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived HGFR protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag.

HY-P703728

	HGF R/c-MET Protein, Mouse (HEK293, His) hepatocyte growth factor receptor; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met; Met; HGF receptor	Mouse	HEK293

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HY-P80803

	Phospho-c-Met (Tyr1349) Antibody MET; hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met	WB, IP	Human
	Phospho-c-Met (Tyr1349) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 156 kDa, targeting to Phospho-c-Met (Tyr1349). It can be used for WB,IP assays with tag free, in the background of Human.

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