2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. GHR

GHR

Growth Hormone Receptor; Somatotropin Receptor; Growth Hormone Binding Protein (GHBP)

Growth hormone (GH), also known as somatotropin, promotes body growth by binding with two GH receptors (GHRs) at the cell surface. GHRs interact with Janus kinase, signal transducers, and transcription activators to stimulate metabolic effects and insulin-like growth factor (IGF) synthesis. However, process dysfunctions in the GH–GHR–IGF-1 axis cause animal dwarfism. If, during the GH process, GHR is not successfully recognized and/or bound, or GHR fails to transmit the GH signal to IGF-1, the GH dysfunction occurs.

GHR Related Products (5):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-164419A
    Atesidorsen sodium
    		Inhibitor
    Atesidorsen sodium is a second-generation, antisense oligomer designed to inhibit translation of human growth hormone receptor (GHR) mRNA
    Atesidorsen sodium
  • HY-153485
    Cimdelirsen
    		Inhibitor
    Cimdelirsen is a novel, ligand-conjugated, hepatic-targeted investigative antisense oligonucleotide designed to reduce growth hormone receptor (GHr) synthesis, thereby inhibiting deleterious effects of growth hormone (GH) hypersecretion and reducing circulating insulin-like growth factor-1 (IGF-1) levels in acromegaly patients.
    Cimdelirsen
  • HY-164419
    Atesidorsen
    		Inhibitor
    Atesidorsen is a second-generation, antisense oligomer designed to inhibit translation of human growth hormone receptor (GHR) mRNA
    Atesidorsen
  • HY-153485A
    Cimdelirsen sodium
    		Inhibitor
    Cimdelirsen is a novel, ligand-conjugated, hepatic-targeted investigative antisense oligonucleotide designed to reduce growth hormone receptor (GHr) synthesis, thereby inhibiting deleterious effects of growth hormone (GH) hypersecretion and reducing circulating insulin-like growth factor-1 (IGF-1) levels in acromegaly patients.
    Cimdelirsen sodium
  • HY-RS05412
    GHR Human Pre-designed siRNA Set A
    		Inhibitor

    GHR Human Pre-designed siRNA Set A contains three designed siRNAs for GHR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    GHR Human Pre-designed siRNA Set A
    GHR Human Pre-designed siRNA Set A