2. Protein Tyrosine Kinase/RTK GPCR/G Protein
  3. c-Met/HGFR Angiotensin Receptor
  4. Norleual TFA

Norleual TFA, an angiotensin (Ang) IV analog, is a hepatocyte growth factor (HGF)/c-Met inhibitor with an IC50 of 3 pM. Norleual TFA is an AT4 receptor antagonist and exhibits potent antiangiogenic activities.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Norleual TFA Chemical Structure

Norleual TFA Chemical Structure

Size Price Stock Quantity
1 mg USD 270 In-stock
5 mg USD 820 In-stock
10 mg USD 1300 In-stock
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100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Norleual TFA:

Norleual TFA Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Norleual TFA

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AT1 Receptor AT2 Receptor

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Norleual TFA, an angiotensin (Ang) IV analog, is a hepatocyte growth factor (HGF)/c-Met inhibitor with an IC50 of 3 pM. Norleual TFA is an AT4 receptor antagonist and exhibits potent antiangiogenic activities[1].

In Vitro

"Norleual TFA at 20 and 50 pM significantly reduces HGF-dependent c-Met and Gab1 phosphorylation. 20 pM Norleual TFA dramatically reduces HGF-initiated association between Gab1 and c-Met in HEK293 cells. Norleual TFA markedly attenuates HGF-dependent c-Met activation and downstream signaling[1]. Norleual TFA (1 pM-1 μM; 4 days) is able to inhibit HGF-dependent signaling, proliferation, migration, and invasion in multiple cell types at concentrations in the picomolar range in MDCK cells[1]."

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Norleual TFA Related Antibodies
In Vivo

Norleual TFA (50 μg/kg; intraperitoneal injection; daily; for 2 weeks; C57BL/6 mice) suppresses pulmonary colonization by B16-F10 murine melanoma cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

888.97

Formula

C43H59F3N8O9
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (56.24 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1249 mL 5.6245 mL 11.2490 mL
5 mM 0.2250 mL 1.1249 mL 2.2498 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.1249 mL 5.6245 mL 11.2490 mL 28.1224 mL
5 mM 0.2250 mL 1.1249 mL 2.2498 mL 5.6245 mL
10 mM 0.1125 mL 0.5624 mL 1.1249 mL 2.8122 mL
15 mM 0.0750 mL 0.3750 mL 0.7499 mL 1.8748 mL
20 mM 0.0562 mL 0.2812 mL 0.5624 mL 1.4061 mL
25 mM 0.0450 mL 0.2250 mL 0.4500 mL 1.1249 mL
30 mM 0.0375 mL 0.1875 mL 0.3750 mL 0.9374 mL
40 mM 0.0281 mL 0.1406 mL 0.2812 mL 0.7031 mL
50 mM 0.0225 mL 0.1125 mL 0.2250 mL 0.5624 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Norleual TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Norleualc-Met/HGFRAngiotensin ReceptorHGFc-MetantiangiogenicAT4Inhibitorinhibitorinhibit

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