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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

human mast cells

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (1) Anaplastic lymphoma kinase (ALK) (1) Antibiotic (2) Apoptosis (2) Bacterial (1) Btk (1) Endogenous Metabolite (3) Fungal (1) GPR35 (1) Histamine Receptor (3) Influenza Virus (1) Interleukin Related (3) Leukotriene Receptor (2) LPL Receptor (2) Parasite (1) Phospholipase (1) Prostaglandin Receptor (2) Protease Activated Receptor (PAR) (1) Ser/Thr Protease (1) STAT (1) Syk (2) TNF Receptor (2)
By Research Areas:	Cancer (3) Endocrinology (2) Infection (4) Inflammation/Immunology (21) Neurological Disease (2)

By Targets:

Adenosine Receptor (1)

Anaplastic lymphoma kinase (ALK) (1)

Antibiotic (2)

Apoptosis (2)

Bacterial (1)

Btk (1)

Endogenous Metabolite (3)

Fungal (1)

GPR35 (1)

Histamine Receptor (3)

Influenza Virus (1)

Interleukin Related (3)

Leukotriene Receptor (2)

LPL Receptor (2)

Parasite (1)

Phospholipase (1)

Prostaglandin Receptor (2)

Protease Activated Receptor (PAR) (1)

Ser/Thr Protease (1)

STAT (1)

Syk (2)

TNF Receptor (2)

By Research Areas:

Cancer (3)

Endocrinology (2)

Infection (4)

Inflammation/Immunology (21)

Neurological Disease (2)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Nuclear Factor of activated T Cells (NFAT)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138961

ER-27319	Syk	Inflammation/Immunology
ER-27319, an acridone derivative, is a potent and selective SYK inhibitor, and inhibits the tyrosine phosphorylation of SYK and its activity. ER-27319 inhibits the release of antigen-induced allergic mediators from human and rat mast cells with an IC₅₀ of 10 μM and can be used for study in allergic diseases .

HY-108489

ER-27319 maleate	Syk	Inflammation/Immunology
ER-27319 (maleate), an acridone derivative, is a potent and selective SKY inhibitor, and inhibits the tyrosine phosphorylation of SYK and its activity. ER-27319 (maleate) inhibits the release of antigen-induced allergic mediators from human and rat mast cells with an IC₅₀ of 10 μM and can be used for study in allergic diseases ^[1] ^[2].

HY-B1404

Nylidrin hydrochloride Buphenine hydrochloride	Others	Inflammation/Immunology
Nylidrin hydrochloride was an effective inhibitor of IgE-mediated release of histamine from passively sensitized rat peritoneal mast cells and human basophils, and of IgG1-mediated release of histamine from passively sensitized guinea pig lung slices.

HY-N11691

Thapsigargicin Thapsigargicine	Others	Inflammation/Immunology
Thapsigargicin (Thapsigargicine) is a activator of mast cells and leukocytes. Thapsigargicin induces histamine release from rat peritoneal mast cells and human basophil leukocytes. Thapsigargicin increases the cytoplasmic free calcium level in intact human blood platelets .

HY-W062109

Olopatadine	Endogenous Metabolite Histamine Receptor	Inflammation/Immunology
Olopatadine is an orally active and selective histamine 1 (H₁) receptor antagonist and a mast cell stabilizer. Olopatadine prevents immunologically stimulated pro-inflammatory mediator release from human conjunctival mast cells. Olopatadine can be used for researching allergic conjunctivitis .

HY-100269

Chymase-IN-1	Others	Inflammation/Immunology
Chymase-IN-1 is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC₅₀ of 29 nM.

HY-W062109S

Olopatadine-d6	Histamine Receptor Endogenous Metabolite	Inflammation/Immunology
Olopatadine-d₆ is the deuterium labeled Olopatadine[1]. Olopatadine is an orally active and selective histamine 1 (H1) receptor antagonist and a mast cell stabilizer. Olopatadine prevents immunologically stimulated pro-inflammatory mediator release from human conjunctival mast cells. Olopatadine can be used for researching allergic conjunctivitis[2][3].

HY-105999A

APC 366 hydrochloride	Ser/Thr Protease	Inflammation/Immunology
APC 366 hydrochloride is a selective inhibitor of mast cell trypsin activity. APC 366 hydrochloride is able to inhibit trypsin-induced histamine release in human tonsil and lung cells. APC 366 hydrochloride may have important applications in regulating allergic reactions and inflammation .

HY-101225

8 Hydroxy PIPAT oxalate	Others	Inflammation/Immunology
8 Hydroxy PIPAT oxalate is a selective 5-HT1A receptor agonist that promotes the release of histamine from enteric mast cells. 8 Hydroxy PIPAT oxalate activates serotonergic signaling pathways, leading to the degranulation of mast cells in both guinea pig and human intestinal preparations. 8 Hydroxy PIPAT oxalate enhances the spontaneous release of histamine, which may contribute to the regulation of gastrointestinal functions. 8 Hydroxy PIPAT oxalate has potential implications for understanding and treating functional gastrointestinal disorders such as irritable bowel syndrome.

HY-110013

Terreic acid	Btk Antibiotic	Infection Inflammation/Immunology
Terreic acid, a quinone epoxide antibiotic, acts as an effective Btk inhibitor. Terreic acid blocks the interaction between PKC and the pleckstrin homology domain of Btk. Terreic acid inhibits the binding of GST-BtkPH to PKC in lysates of HMC-1 human mast cells with an IC₅₀ of approximately 100 μM .

HY-103183

CV1808 2-Phenylaminoadenosine	Adenosine Receptor Endogenous Metabolite	Inflammation/Immunology
CV1808 (2-Phenylaminoadenosine) is a non-selective A2 adenosine receptor (A2 AR) agonist with K_is of 76 and 1450 nM for A2A and A3 adenosine receptor subtypes, respectively .

HY-130592

Compound 48/80 trihydrochloride C48/80 trihydrochloride	Phospholipase	Neurological Disease
Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde. Compound 48/80 trihydrochloride is also a histamine releaser and a **mast cell degranulator. Compound 48/80 inhibits phosphatidylinositol-specific phospholipase C** activity from human platelets .

HY-N3421

Koaburaside	Interleukin Related TNF Receptor Influenza Virus	Infection Inflammation/Immunology Cancer
Koaburaside is a cytoprotective and anti-inflammatory natural compound. Koaburaside shows antioxidant activity with an IC₅₀ of 9.0 μM for DPPH-free radical scavenging assay. Koaburaside inhibits histamine release and expressions of IL-6 and TNF-α in human mast cells. Koaburaside also effectively inhibits influenza A neuraminidase .

HY-168532

ST2-IN-1	Interleukin Related	Inflammation/Immunology
ST2-IN-1 (compound 31) is a Stimulation-2 (ST2) inhibitor, with an IC₅₀ value of 7 μM in AlphaLISA assay, and 7.19 μM in HEK-Blue assay. ST2-IN-1 effectively attenuats the ST2/IL-33 signaling in human mast cells .

HY-N4126

6-Demethoxytangeretin	Anaplastic lymphoma kinase (ALK)	Neurological Disease Inflammation/Immunology Cancer
6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus reticulata. 6-Demethoxytangeretin exerts anti-inflammatory activity and anti-allergic activity, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase (ALK) and mitogen-activated protein kinase (MAPK) pathways . 6-Demethoxytangeretin facilitates the CRE-mediated transcription associated with learning and memory in cultured hippocampal neurons .

HY-A0059

Nifuratel 3 Publications Verification NF 113; SAP 113; Methylmercadone	Bacterial Parasite Antibiotic Fungal Apoptosis STAT Interleukin Related TNF Receptor	Infection Inflammation/Immunology Cancer
Nifuratel (NF 113) is an orally active broad-spectrum antibiotic with antiprotozoal, antibacterial, anticancer and anti-inflammatory activities, and has good inhibitory effects on Candida and Trichomonas. Nifuratel is also a STAT3 inhibitor, which significantly inhibits the growth and proliferation of human gastric cancer cells and induces apoptosis. In addition, Nifuratel also inhibits mast cell-mediated antigen hypersensitivity reactions and can be used in the study of IgE-mediated allergic diseases .

HY-15342

Timapiprant 3 Publications Verification OC000459	Prostaglandin Receptor	Inflammation/Immunology Endocrinology
Timapiprant (OC000459) is a potent, selective, and orally active D prostanoid receptor 2 (DP₂, also known as CRTH2) antagonist. Timapiprant (OC000459) potently displaces [ ³H] PGD2 from human recombinant DP₂ (K_i=13 nM), rat recombinant DP₂ (K_i=3 nM), and human native DP₂ (K_i=4 nM). Timapiprant (OC000459) inhibits mast cell activation of Th2 lymphocytes and eosinophils .

HY-15342A

Timapiprant sodium 3 Publications Verification OC000459 sodium	Prostaglandin Receptor	Inflammation/Immunology Endocrinology
Timapiprant sodium (OC000459 sodium) is a potent, selective, and orally active D prostanoid receptor 2 (DP₂, also known as CRTH2) antagonist. Timapiprant sodium (OC000459 sodium) potently displaces [ ³H] PGD2 from human recombinant DP₂ (K_i=13 nM), rat recombinant DP₂ (K_i=3 nM), and human native DP₂ (K_i=4 nM). Timapiprant sodium (OC000459 sodium) inhibits mast cell activation of Th2 lymphocytes and eosinophils .

HY-158316

BTL-MK	Others	Others
BTL-MK (Compound 19) an orally active antiallergic agent, that inhibits degranulation of mast cells with an IC₅₀ of 6.7 μM, through binding to the inhibitory receptor FcγRIIB. BTL-MK improves the metaboilic stability in human liver microsomes. BTL-MK ameliorates the allergic response in Ovalbumins (HY-W250978)-induced food allergy mice model. BTL-MK exhibits a good pharmacokinetic character with metabolic stability .

HY-P99371

Lirentelimab AK002; Anti-Siglec-8 Reference Antibody (lirentelimab)	Apoptosis	Inflammation/Immunology
Lirentelimab (AK002) is a humanized IgG1 monoclonal antibody that targets sialic acid-binding Ig-like lectin 8 (SIGLEC8). Lirentelimab induces cell apoptosis of IL-5-activated eosinophils and inhibits IgE-mediated mast cell activation. Lirentelimab can be used for the research of eosinophilic gastritis and duodenitis .

HY-106481

Bufrolin	GPR35 Histamine Receptor	Inflammation/Immunology
Bufrolin is a Cromoglycate (histamine release inhibitor) analog and a high potency agonist of GPR35. Bufrolin promotes interactions between β-arrestin-2 and either human GPR35a or rat GPR35. Bufrolin also serves as antiallergic mast cell stabilizer and inhibit an anti-inflammatory response inducible by the internalization peptide. Bufrolin acts as an anti-inflammatory agent to be used in research of delivering pharmacol linked with internalization peptide .

HY-19989

MK-571 Maximum Cited Publications 24 Publications Verification L-660711	Leukotriene Receptor LPL Receptor	Inflammation/Immunology
MK-571 (L-660711) is an orally active, potent and selective competitive leukotriene D₄ (LTD₄) receptor antagonist, with K_i values of 0.22 and 2.1 nM in guinea pig and human lung membranes, respectively. MK-571 is also a MRP4 and ABCC1 (MRP1) inhibitor. MK-571 inhibits constitutive and antigen-stimulated S1P (sphingosine-1-phosphate) release .

HY-19989A

MK-571 sodium L-660711 sodium	Leukotriene Receptor LPL Receptor	Inflammation/Immunology
MK-571 (L-660711) sodium is an orally active, potent and selective competitive leukotriene D₄ (LTD₄) receptor antagonist, with K_i values of 0.22 and 2.1 nM in guinea pig and human lung membranes, respectively. MK-571 sodium is also a inhibitor of multidrug resistance-associated protein MRP4 (ABCC4) and ABCC1 (MRP1). MK-571 sodium inhibits constitutive and antigen-stimulated S1P (sphingosine-1-phosphate) release .

HY-P5357

SFNGGP-NH2	Protease Activated Receptor (PAR)	Others
SFNGGP-NH2 is a biological active peptide. (PAR-3 is a high-affinity thrombin receptor. PAR-3 mRNA is expressed in the cutaneous mast cells of humans. Protease-Activated Receptors (PARs) have been studied for their roles in itch and their itch-associated response through histamine-dependent/independent pathways have been reported. PAR-3 has been shown not to induce itching alone but possibly in conjunction with PAR-4. Co-expression of PAR-3 and PAR-4 enhances thrombin action suggesting that PAR-3 alone does not mediate transmembrane signaling but instead functions as a cofactor to activate PAR-4.)

Cat. No.	Product Name	Target	Research Area

HY-P5727

HR1	Peptides	Infection
HR1 is a mastoid protease. HR1 can increase the permeability of human erythrocyte membrane. HR1 can induce cytoplasmic membrane permeation in bacteria and mast cells .