Terreic acid 

Terreic acid, a quinone epoxide antibiotic, acts as an effective Btk inhibitor. Terreic acid blocks the interaction between PKC and the pleckstrin homology domain of Btk. Terreic acid inhibits the binding of GST-BtkPH to PKC in lysates of HMC-1 human mast cells with an IC₅₀ of approximately 100 μM^[1].

Btk; Antibiotic^[1]

Terreic acid inhibits the association of Btk with PKCβII in mouse mast cells at lower concentrations (IC₅₀ of ≈30 μM). Terreic acid inhibits the catalytic activity of Btk but not PKC^[1].
Terreic acid (pretreatment for 30 min before stimulation by antigen for 3 min) inhibits both the basal and activation levels of Btk autophosphorylating activity with IC₅₀s of 10 μM and 3 μM, respectively^[1].
Terreic acid inhibits the autophosphorylating activity of Btk purified partially from recombinant baculovirus-infected Sf9 insect cells in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Terreic acid inhibits the late-phase response of in vivo allergic cutaneous reactions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

154.12

C₇H₆O₄

121-40-4

Solid

White to off-white

O=C1[C@@H]2[C@H](C(C(O)=C1C)=O)O2

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. Y Kawakami, et al. Terreic acid, a quinone epoxide inhibitor of Bruton's tyrosine kinase. Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2227-32.  [Content Brief]