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  4. Lirentelimab

Lirentelimab  (Synonyms: AK002; Antolimab)

Cat. No.: HY-P99371 Purity: 99.91%
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Lirentelimab (AK002) is a humanized IgG1 monoclonal antibody that targets sialic acid-binding Ig-like lectin 8 (SIGLEC8). Lirentelimab induces cell apoptosis of IL-5-activated eosinophils and inhibits IgE-mediated mast cell activation. Lirentelimab can be used for the research of eosinophilic gastritis and duodenitis.

For research use only. We do not sell to patients.

CAS No. : 2283348-97-8

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Description

Lirentelimab (AK002) is a humanized IgG1 monoclonal antibody that targets sialic acid-binding Ig-like lectin 8 (SIGLEC8). Lirentelimab induces cell apoptosis of IL-5-activated eosinophils and inhibits IgE-mediated mast cell activation. Lirentelimab can be used for the research of eosinophilic gastritis and duodenitis[1].

In Vitro

Monovalent Lirentelimab fragment antigen-binding (fab) binds to recombinant SIGLEC8 extracellular domain (ECD) is determined to be 464 pM[1].
Lirentelimab shows high affinity to SIGLEC8 in vitro, to SIGLEC8 expressed on eosinophils, and to NK cells via its Fc region in human blood[1].
Lirentelimab (1 µg/mL) selectively binds to eosinophils in human peripheral blood, and eosinophils and mast cells from human lung tissue[1].
Lirentelimab (0.0001-100 μg/mL; 30 min) induces apoptosis of IL-5-activated eosinophils[1].
Lirentelimab (30 min) shows potent antibody-dependent cell-mediated cytotoxicity (ADCC) Activity on human eosinophils with an EC50 value of 1.9 ng/mL to eosinophils in peripheral blood leukocytes (PBL) preparations from healthy donors[1].
Lirentelimab reduces eosinophil numbers in ex vivo human tissue[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Apoptosis Analysis[1]

Cell Line: Eosinophils
Concentration: 10 μg/mL-1 pg/mL
Incubation Time: 30 min
Result: Dose-dependently induced apoptosis of IL-5-activated (50 ng/mL) eosinophils.
In Vivo

Lirentelimab (100 μg; i.v. once) significantly inhibits IgE-mediated mast cell activation in a mice model of systemic anaphylaxis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Humanized mice (NSG-SGM3) engrafts with human thymus, liver, and HSC[1]
Dosage: 100 μg
Administration: Intravenous injection; 100 μg, once
Result: Completely prevented passive systemic anaphylaxis (PSA) as shown by a lack of change in rectal temperature and symptom scores in mice.
Clinical Trial
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Colorless to light yellow

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[Lirentelimab]
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  • Human IgG1 kappa
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lirentelimab2283348-97-8AK002 AntolimabAK 002AK-002Apoptosismonoclonal antibodyapoptosiseosinophilmast cellduodenitiseosinophilic gastritishuman bloodADCCInhibitorinhibitorinhibit

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