Search Result

Results for "

marine sponges

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Apoptosis (4) Arp2/3 Complex (1) Autophagy (2) Bacterial (6) CDK (1) ERK (1) FAK (1) Fungal (3) HIV (3) JNK (1) Microtubule/Tubulin (2) mTOR (1) p38 MAPK (1) Parasite (2) PI3K (2) Reactive Oxygen Species (1) Sodium Channel (1) TRP Channel (1)
By Research Areas:	Cancer (16) Infection (10) Inflammation/Immunology (2) Neurological Disease (3)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-119500

Ilimaquinone	HIV Bacterial	Infection Inflammation/Immunology Cancer
Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway. Ilimaquinone can induce vesiculation of the Golgi apparatus . Ilimaquinone exerts anti-HIV, anti-microbial, anti-inflammatory, and effects .

HY-P0027

Jasplakinolide 5 Publications Verification	Arp2/3 Complex Fungal	Infection Cancer
Jasplakinolide is a potent actin polymerization inducer and stabilizes pre-existing actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a K_d of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity .

HY-N1662

2,4,6,6-Tetramethyl-3(6H)-pyridinone	Others	Others
2,4,6,6-Tetramethyl-3(6H)-pyridinone is a natural product that can be isolated from the tropical marine sponge Agelas oroides .

HY-116436

Clathrodin	Sodium Channel	Neurological Disease
Clathrodin is a marine alkaloid that can be isolated from sponges of the genus, Agelas. Clathrodin is a modulator of voltage-gated sodium (NaV) channels. Clathrodin is a sodium channel neurotoxin influencing sodium channel ionic conductance .

HY-127085

Acanthifolicin Acanthifolic acid	Others	Cancer
Acanthifolicin (Acanthifolic acid) is a tumor promoter that can be isolated from the marine sponge Pandaros acanthifolium .

HY-N12524

Cyclo(prolyltyrosyl)	Bacterial	Infection Cancer
Cyclo(prolyltyrosyl) is a natural compound that can be found in various microorganisms and marine sponges. Cyclo(prolyltyrosyl) has antibacterial, phytotoxic and cytotoxic properties .

HY-119729

Axinysterol	Others	Cancer
Axinysterol is a steroidal compound isolated from marine sponges of the genus Axinyssa, possessing anticancer activity. Axinysterol is employed in research within the field of oncology .

HY-125660

Leucettamol A	Others	Infection
Leucettamol A is an inhibitor of Ubc13-Uev1A interaction, with an IC₅₀ of 50 μg/mL. Leucettamol A can be isolated from a marine sponge, Leucetta aff. Microrhaphis .

HY-N6997

Ceratamine A	Microtubule/Tubulin	Cancer
Ceratamine A is an antimitotic heterocyclic alkaloid isolated from the marine sponge Pseudoceratina sp., acts as a microtubule-stabilizing agent. Ceratamine A exhibits cytotoxicity against human cancer cell lines .

HY-N12605

hTRPA1-IN-1	TRP Channel	Neurological Disease
hTRPA1-IN-1 (19), a norsesterterpenoid that can be isolated from the Marine Sponge Diacarnus spinipoculum, is an inhibitor of transient receptor potential Ankyrin 1 (TRPA1), with an IC₅₀ of 2 μM .

HY-19922

Plocabulin PM060184	Microtubule/Tubulin	Cancer
Plocabulin (PM060184) is a potent microtubule inhibitor. Plocabulin is a natural product that could be isolated from the marine sponge Lithoplocamia lithistoides. Plocabulin suppresses microtubule shortening and growth. Plocabulin has anticancer activity .

HY-111266

Halenaquinone	PI3K Apoptosis	Inflammation/Immunology Cancer
Halenaquinone is a phosphatidylinositol 3-kinase inhibitor and can be isolated from the marine sponge Petrosia alfiani. Halenaquinone inhibits RANKL-induced osteoclastogenesis, and induces cell apoptosis in PC12 cells .

HY-N7234

Sarasinoside C1	Others	Others
Sarasinoside C1 is a 30-norlanostane saponin isolated from the sea sponge Melophlus sarasinorum collected from Kimbe Bay, Papua New Guinea. Sarasinoside C1 has potential roles in marine ecology and pharmacological applications .

HY-W065835

2-Bromoaldisine	HIV	Infection
2-Bromoaldisine is a pyrrole alkaloid that can be isolated from the Red Sea: marine sponge Stylissa carter. 2-Bromoaldisine inhibits HIV-1 vector infection. 2-Bromoaldisine inhibits Raf/MEK/MAPK pathway .

HY-N10401

Batzelladine D	Fungal Bacterial Parasite	Infection Cancer
Batzelladine D (Compound 1) is an inhibitor of the catalytic and functional activity of Pdr5p transporter. Batzelladine D inhibits Pdr5p ATPase activity with an IC₅₀ of 7.1 µM. Batzelladine D shows antifungal, antiparasitic, antiviral, antibacterial and antitumoral activities .

HY-N10402

Norbatzelladine L	Fungal Bacterial Parasite	Infection Cancer
Norbatzelladine L (Compound 2) is an inhibitor of the catalytic and functional activity of Pdr5p transporter. Norbatzelladine L inhibits Pdr5p ATPase activity with an IC₅₀ of 3.8 µM. Norbatzelladine L shows antifungal, antiparasitic, antiviral, antibacterial and antitumoral activities .

HY-121014

Amphimedine	Others	Cancer
Amphimedine is a polycyclic alkaloid isolated from the marine sponge Amphimedon sp. and belongs to the pyridoindole alkaloid class. Amphimedine has cytotoxic activity and has been studied as an anticancer metabolite along with neoamphimedine. Studies have shown that deoxyamphimedine damages DNA by generating reactive oxygen species, a mechanism different from that of amphimedine.

HY-112328

Fascaplysin	Apoptosis Autophagy Reactive Oxygen Species CDK	Infection Cancer
Fascaplysin is an antimicrobial and cytotoxic red pigment, that can come from the marine sponge (Fascaplysinopsis sp.). Fascaplysin has been synthesized in seven steps from indole (65% yield). Fascaplysin can induces apoptosis and autophagy in human leukemia HL-60 cells. Fascaplysin shows anti-tumor activity .

HY-19827

Aeroplysinin 1 (+)-Aeroplysinin-1	Bacterial HIV Apoptosis	Infection Cancer
Aeroplysinin 1 ((+)-Aeroplysinin-1), a secondary metabolite isolated from marine sponges, shows potent antibiotic effects on Gram-positive bacteria and exerts antiviral activity against HIV-1 (IC₅₀=14.6 μM). Aeroplysinin 1 has anti-inflammatory, anti-angiogenic and anti-tumor activities. Aeroplysinin 1 induces apoptosis in endothelial cells .

HY-119387

Chevalone B	Bacterial	Infection
Chevalone B was isolated from the ethyl acetate extract of the marine sponge-associated fungus Aspergillus similanensis. The structure of Chevalone B was confirmed by 1D and 2D NMR spectroscopy. Chevalone B showed antimicrobial activity against Gram-positive and Gram-negative bacteria, Candida albicans, and multidrug-resistant strains from the environment. Studies on Chevalone B have shown its potential value in antimicrobial applications.

HY-N12561

Pestanoid A	ERK p38 MAPK JNK	Others
Pestanoid A is a rearranged pimarane diterpenoid osteoclastogenesis inhibitor with an IC₅₀ of 4.2 μM. Pestanoid A can be isolated from the marine mesophotic zone chalinidae sponge-associated fungus, Pestalotiopsis sp. NBUF145. Pestanoid A inhibits the receptor activator of NF-kB ligand-induced MAPK and NF-κB signaling by suppressing the phosphorylation of ERK1/2-JNK1/2-p38 MAPKs and NF-κB nuclear translocation. Pestanoid A can be used for the study of osteoporosis .

HY-W003793

Ethyl 6-bromo-1H-indole-3-carboxylate	Others	Cancer
Ethyl 6-bromo-1H-indole-3-carboxylate is a marine-derived natural product with anti-tumor activity. Ethyl 6-bromo-1H-indole-3-carboxylate was isolated from the sponge Iotrochota purpurea collected in Indonesia. The structure of Ethyl 6-bromo-1H-indole-3-carboxylate was confirmed by spectroscopic methods and accurate mass measurements .

HY-120985

Araguspongin B	Others	Neurological Disease
Xestospongins and araguspongins are marine natural products first isolated from Pacific basin sponges, and noted to have vasodilatory properties.1 Inositol phosphates (IP) are important signal transduction messengers acting via IP3 receptors to promote the mobilization of Ca2+ from intracellular stores.2 Araguspongin B antagonizes the calcium-releasing action of inositol 1,4,5-trisphosphate at the receptor level in cerebral microsomes, with an IC₅₀ of 0.6 μM. It is nearly as potent as xestospongin C as an antagonist of the IP3 receptor.

HY-138098

Sartorypyrone B	Others	Cancer
Sartorypyrone B is a 2β-acetoxyl analogue of chevalone C. Sartorypyrone B is yielded from the ethyl acetate extract of the culture of the marine sponge-associated fungus Neosartorya tsunodae (KUFC 9213). Sartorypyrone B exhibits strong growth inhibitory activity, having GI₅₀s of 17.8, 20.5, and 25.0 μM, respectively, for MCF-7, NCI-H460, and A375-C5. Sartorypyrone B has the potential for the research of breast adenocarcinoma, non-small cell lung cancer, and melanoma diseases .

HY-N13176

Stellettin B	Autophagy Apoptosis PI3K Akt mTOR FAK	Cancer
Stellettin B is a triterpenoid compound that can be isolated from the marine sponge Jaspis stellifera. Stellettin B induces G1 phase arrest, apoptosis, and autophagy in human non-small cell lung cancer A549 cells by blocking the PI3K/Akt/mTOR pathway. Stellettin B can reduce the migration and invasion of liver cancer cells by decreasing the activation of the MAPK and FAK/PI3K/AKT/mTOR signaling pathways. Stellettin B can be used in the study of various tumors .

Cat. No.	Product Name

HY-L143

Marine-Sourced Natural Product Library	45 compounds
Oceans cover more than 70% of the Earth’s surface and host a huge species diversity. Marine organisms are considered the most recent source of bioactive natural products after terrestrial plants and nonmarine microorganisms. Marine biological sources are taxonomically diverse and include sponges, tunicates, corals, mollusks, fungi, and sediment-derived bacteria. Marine organisms can produce a plethora of small molecules with novel chemical structures and potent biological properties, being a rich source for the discovery of pharmacologically active compounds, already with several marine-derived agents approved as drugs. Ziconotide, a peptide originally discovered in a tropical cone snail, was the first marine-derived compound to be approved in the United States in December 2004 for the treatment of pain. Then, in October 2007, Trabectedin became the first marine anticancer drug to be approved in the European Union. MCE offers a unique collection of 45 marine-sourced natural products which can be used for drug discovery for high throughput screening (HTS) and high content screening (HCS). MCE marine-sourced natural product library is an important source for drug discovery and development.

Marine-Sourced Natural Product Library

45 compounds

Oceans cover more than 70% of the Earth’s surface and host a huge species diversity. Marine organisms are considered the most recent source of bioactive natural products after terrestrial plants and nonmarine microorganisms. Marine biological sources are taxonomically diverse and include sponges, tunicates, corals, mollusks, fungi, and sediment-derived bacteria.

Marine organisms can produce a plethora of small molecules with novel chemical structures and potent biological properties, being a rich source for the discovery of pharmacologically active compounds, already with several marine-derived agents approved as drugs. Ziconotide, a peptide originally discovered in a tropical cone snail, was the first marine-derived compound to be approved in the United States in December 2004 for the treatment of pain. Then, in October 2007, Trabectedin became the first marine anticancer drug to be approved in the European Union.

MCE offers a unique collection of 45 marine-sourced natural products which can be used for drug discovery for high throughput screening (HTS) and high content screening (HCS). MCE marine-sourced natural product library is an important source for drug discovery and development.

Cat. No.	Product Name	Target	Research Area

HY-P0027

Jasplakinolide 5 Publications Verification	Arp2/3 Complex Fungal	Infection Cancer
Jasplakinolide is a potent actin polymerization inducer and stabilizes pre-existing actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a K_d of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity .

Ilimaquinone	Infection Quinones Classification of Application Fields Animals Marine natural products Benzene Quinones Sponge Inflammation/Immunology Disease Research Fields Cancer	HIV Bacterial
Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway. Ilimaquinone can induce vesiculation of the Golgi apparatus . Ilimaquinone exerts anti-HIV, anti-microbial, anti-inflammatory, and effects .

Jasplakinolide 5 Publications Verification	Structural Classification Antifungal Classification of Application Fields Marine natural products Source classification Disease Research Other Antibiotics Infection Monophenols Animals Antibiotics Cyclopeptides Phenols Sponge Anticancer Disease Research Fields	Arp2/3 Complex Fungal
Jasplakinolide is a potent actin polymerization inducer and stabilizes pre-existing actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a K_d of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity .

2,4,6,6-Tetramethyl-3(6H)-pyridinone	Alkaloids Classification of Application Fields Animals Marine natural products Other Diseases Pyridine Alkaloids Sponge Disease Research Fields	Others
2,4,6,6-Tetramethyl-3(6H)-pyridinone is a natural product that can be isolated from the tropical marine sponge Agelas oroides .

Acanthifolicin Acanthifolic acid	Structural Classification Natural Products Marine natural products Source classification Sponge	Others
Acanthifolicin (Acanthifolic acid) is a tumor promoter that can be isolated from the marine sponge Pandaros acanthifolium .

Cyclo(prolyltyrosyl)	Structural Classification Alkaloids Pyrrole Alkaloids Source classification Endogenous metabolite	Bacterial
Cyclo(prolyltyrosyl) is a natural compound that can be found in various microorganisms and marine sponges. Cyclo(prolyltyrosyl) has antibacterial, phytotoxic and cytotoxic properties .

Axinysterol	Structural Classification Natural Products Marine natural products Source classification Sponge	Others
Axinysterol is a steroidal compound isolated from marine sponges of the genus Axinyssa, possessing anticancer activity. Axinysterol is employed in research within the field of oncology .

Ceratamine A	Alkaloids Classification of Application Fields Animals Source classification Disease Research Fields Cancer	Microtubule/Tubulin
Ceratamine A is an antimitotic heterocyclic alkaloid isolated from the marine sponge Pseudoceratina sp., acts as a microtubule-stabilizing agent. Ceratamine A exhibits cytotoxicity against human cancer cell lines .

hTRPA1-IN-1	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	TRP Channel
hTRPA1-IN-1 (19), a norsesterterpenoid that can be isolated from the Marine Sponge Diacarnus spinipoculum, is an inhibitor of transient receptor potential Ankyrin 1 (TRPA1), with an IC₅₀ of 2 μM .

Plocabulin PM060184	Structural Classification Natural Products Animals Source classification	Microtubule/Tubulin
Plocabulin (PM060184) is a potent microtubule inhibitor. Plocabulin is a natural product that could be isolated from the marine sponge Lithoplocamia lithistoides. Plocabulin suppresses microtubule shortening and growth. Plocabulin has anticancer activity .

Halenaquinone	Structural Classification Natural Products Marine natural products Source classification Sponge	PI3K Apoptosis
Halenaquinone is a phosphatidylinositol 3-kinase inhibitor and can be isolated from the marine sponge Petrosia alfiani. Halenaquinone inhibits RANKL-induced osteoclastogenesis, and induces cell apoptosis in PC12 cells .

2-Bromoaldisine	Structural Classification Alkaloids Pyrrole Alkaloids Marine natural products Source classification	HIV
2-Bromoaldisine is a pyrrole alkaloid that can be isolated from the Red Sea: marine sponge Stylissa carter. 2-Bromoaldisine inhibits HIV-1 vector infection. 2-Bromoaldisine inhibits Raf/MEK/MAPK pathway .

Batzelladine D	Infection Alkaloids Structural Classification Classification of Application Fields Animals Other Alkaloids Marine natural products Sponge Disease Research Fields Cancer	Fungal Bacterial Parasite
Batzelladine D (Compound 1) is an inhibitor of the catalytic and functional activity of Pdr5p transporter. Batzelladine D inhibits Pdr5p ATPase activity with an IC₅₀ of 7.1 µM. Batzelladine D shows antifungal, antiparasitic, antiviral, antibacterial and antitumoral activities .

Norbatzelladine L	Alkaloids Microorganisms Source classification	Fungal Bacterial Parasite
Norbatzelladine L (Compound 2) is an inhibitor of the catalytic and functional activity of Pdr5p transporter. Norbatzelladine L inhibits Pdr5p ATPase activity with an IC₅₀ of 3.8 µM. Norbatzelladine L shows antifungal, antiparasitic, antiviral, antibacterial and antitumoral activities .

Amphimedine	Structural Classification Alkaloids Marine natural products Source classification Pyridine Alkaloids Sponge	Others
Amphimedine is a polycyclic alkaloid isolated from the marine sponge Amphimedon sp. and belongs to the pyridoindole alkaloid class. Amphimedine has cytotoxic activity and has been studied as an anticancer metabolite along with neoamphimedine. Studies have shown that deoxyamphimedine damages DNA by generating reactive oxygen species, a mechanism different from that of amphimedine.

Fascaplysin	Infection Alkaloids Structural Classification Classification of Application Fields Animals Marine natural products Sponge Disease Research Fields Indole Alkaloids Cancer	Apoptosis Autophagy Reactive Oxygen Species CDK
Fascaplysin is an antimicrobial and cytotoxic red pigment, that can come from the marine sponge (Fascaplysinopsis sp.). Fascaplysin has been synthesized in seven steps from indole (65% yield). Fascaplysin can induces apoptosis and autophagy in human leukemia HL-60 cells. Fascaplysin shows anti-tumor activity .

Aeroplysinin 1 (+)-Aeroplysinin-1	Structural Classification Anti-inflammation/Immunoregulatory Classification of Application Fields Source classification Marine natural products Antibacterial Disease Research Other Antibiotics Infection Animals Antibiotics Antiviral Sponge Anticancer Disease Research Fields	Bacterial HIV Apoptosis
Aeroplysinin 1 ((+)-Aeroplysinin-1), a secondary metabolite isolated from marine sponges, shows potent antibiotic effects on Gram-positive bacteria and exerts antiviral activity against HIV-1 (IC₅₀=14.6 μM). Aeroplysinin 1 has anti-inflammatory, anti-angiogenic and anti-tumor activities. Aeroplysinin 1 induces apoptosis in endothelial cells .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks