2. Cytoskeleton Anti-infection
  3. Arp2/3 Complex Fungal
  4. Jasplakinolide

Jasplakinolide is a potent actin polymerization inducer and stabilizes pre-existing actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a Kd of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity.

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Jasplakinolide Chemical Structure

Jasplakinolide Chemical Structure

CAS No. : 102396-24-7

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Jasplakinolide Related Antibodies

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Description

Jasplakinolide is a potent actin polymerization inducer and stabilizes pre-existing actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a Kd of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity[1][2].

Cellular Effect
Cell Line Type Value Description References
786-0 GI50
0.02 μM
Compound: 1
Growth inhibition of human 786-0 cells by sulforhodamine B assay
Growth inhibition of human 786-0 cells by sulforhodamine B assay
[PMID: 20121114]
CA46 IC50
0.03 μM
Compound: 5
Antiproliferative activity against human CA46 cells after 24 hrs
Antiproliferative activity against human CA46 cells after 24 hrs
[PMID: 12088429]
CA46 IC50
10 nM
Compound: 1
Growth inhibition of human CA46 cells assessed as induction of actin assembly after 24 hrs
Growth inhibition of human CA46 cells assessed as induction of actin assembly after 24 hrs
[PMID: 20678932]
HCT-116 GI50
0.1 μM
Compound: 1
Growth inhibition of human HCT116 cells by sulforhodamine B assay
Growth inhibition of human HCT116 cells by sulforhodamine B assay
[PMID: 20121114]
HCT-15 GI50
0.69 μM
Compound: 1
Growth inhibition of human HCT15 cells by sulforhodamine B assay
Growth inhibition of human HCT15 cells by sulforhodamine B assay
[PMID: 20121114]
HOP-62 GI50
0.15 μM
Compound: 1
Growth inhibition of human HOP62 cells by sulforhodamine B assay
Growth inhibition of human HOP62 cells by sulforhodamine B assay
[PMID: 20121114]
KB IC50
0.013 μM
Compound: 1, jasplakinolide
Growth inhibition of human KB cells after 72 hrs by CellTiter 96 assay
Growth inhibition of human KB cells after 72 hrs by CellTiter 96 assay
[PMID: 22364566]
M14 GI50
0.056 μM
Compound: 1
Growth inhibition of human M14 cells by sulforhodamine B assay
Growth inhibition of human M14 cells by sulforhodamine B assay
[PMID: 20121114]
OVCAR-3 GI50
0.04 μM
Compound: 1
Growth inhibition of human OVCAR-3 cells by sulforhodamine B assay
Growth inhibition of human OVCAR-3 cells by sulforhodamine B assay
[PMID: 20121114]
SF-539 GI50
0.3 μM
Compound: 1
Growth inhibition of human SF539 cells by sulforhodamine B assay
Growth inhibition of human SF539 cells by sulforhodamine B assay
[PMID: 20121114]
In Vitro

Jasplakinolide has an IC50 of 35 nM for the antiproliferative effect of jasplakinolide on PC3 prostate carcinoma cells[2].
Jasplakinolide (10 μM; for 2 hours) generates binucleated cells when applied during mitosis. Jasplakinolide induces the formation of F-actin-containing apical extensions in Toxoplasma gondii tachyzoites[2].
Jasplakinolide (1 mM; for 60 min) induces the formation of actin-containing apical extensions in isolated Toxoplasma gondii tachyzoites fixed[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Jasplakinolide Related Antibodies
Molecular Weight

709.67

Formula

C36H45BrN4O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

BrC1=C(C2=CC=CC=C2N1)C[C@@H](N(C([C@@H](NC([C@H](C/C(C)=C/[C@@H]3C)C)=O)C)=O)C)C(N[C@](C(C=C4)=CC=C4O)([H])CC(O[C@H](C3)C)=O)=O
Structure Classification
Initial Source

marine sponge
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (14.09 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4091 mL 7.0455 mL 14.0911 mL
5 mM 0.2818 mL 1.4091 mL 2.8182 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.5%

SDS (393 KB)

COA (266 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4091 mL 7.0455 mL 14.0911 mL 35.2276 mL
5 mM 0.2818 mL 1.4091 mL 2.8182 mL 7.0455 mL
10 mM 0.1409 mL 0.7046 mL 1.4091 mL 3.5228 mL
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Jasplakinolide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Jasplakinolide102396-24-7Arp2/3 ComplexFungalActin-related protein 2/3 complexactinpolymerizationinducerstabilizesF-actinphalloidincyclicpeptidemarinespongefungicidalanti-cancerInhibitorinhibitorinhibit

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