Araguspongin B

Cat. No.: HY-120985: FAQs
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Xestospongins and araguspongins are marine natural products first isolated from Pacific basin sponges, and noted to have vasodilatory properties.1 Inositol phosphates (IP) are important signal transduction messengers acting via IP3 receptors to promote the mobilization of Ca2+ from intracellular stores.2 Araguspongin B antagonizes the calcium-releasing action of inositol 1,4,5-trisphosphate at the receptor level in cerebral microsomes, with an IC₅₀ of 0.6 μM. It is nearly as potent as xestospongin C as an antagonist of the IP3 receptor.

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Araguspongin B Chemical Structure

CAS No. : 123000-02-2

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Description	Xestospongins and araguspongins are marine natural products first isolated from Pacific basin sponges, and noted to have vasodilatory properties.1 Inositol phosphates (IP) are important signal transduction messengers acting via IP3 receptors to promote the mobilization of Ca2+ from intracellular stores.2 Araguspongin B antagonizes the calcium-releasing action of inositol 1,4,5-trisphosphate at the receptor level in cerebral microsomes, with an IC₅₀ of 0.6 μM. It is nearly as potent as xestospongin C as an antagonist of the IP3 receptor.
Molecular Weight	444.74
Formula	C₂₉H₅₂N₂O
CAS No.	123000-02-2
SMILES	[H][C@@]1(CCC2)[C@]3([H])N2CC[C@@](CCCCCC[C@@]4([H])[C@@]5([H])O[C@@](CCN5CCC4)([H])CCCCCC1)([H])C3
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (266 KB) Handling Instructions (2659 KB)
References	[1]. Majerus, et al. Inositol phosphate biochemistry. Annu. Rev. Biochem. 61, 225-250 (1992).

Araguspongin B Related Classifications

Neurological Disease

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	×		=		×
C1		V1		C2		V2

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Do most proteins show cross-species activity?
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Araguspongin B123000-02-2OthersInhibitorinhibitorinhibit

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Araguspongin B

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