2. Autophagy Apoptosis PI3K/Akt/mTOR Protein Tyrosine Kinase/RTK
  3. Autophagy Apoptosis PI3K Akt mTOR FAK
  4. Stellettin B

Stellettin B is a triterpenoid compound that can be isolated from the marine sponge Jaspis stellifera. Stellettin B induces G1 phase arrest, apoptosis, and autophagy in human non-small cell lung cancer A549 cells by blocking the PI3K/Akt/mTOR pathway. Stellettin B can reduce the migration and invasion of liver cancer cells by decreasing the activation of the MAPK and FAK/PI3K/AKT/mTOR signaling pathways. Stellettin B can be used in the study of various tumors.

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Stellettin B Chemical Structure

Stellettin B Chemical Structure

CAS No. : 184885-91-4

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Stellettin B Related Antibodies

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Description

Stellettin B is a triterpenoid compound that can be isolated from the marine sponge Jaspis stellifera. Stellettin B induces G1 phase arrest, apoptosis, and autophagy in human non-small cell lung cancer A549 cells by blocking the PI3K/Akt/mTOR pathway. Stellettin B can reduce the migration and invasion of liver cancer cells by decreasing the activation of the MAPK and FAK/PI3K/AKT/mTOR signaling pathways. Stellettin B can be used in the study of various tumors[1][2].
Cellular Effect
Cell Line Type Value Description References
Bel-7402 IC50
> 5 μg/mL
Compound: 8
Cytotoxicity against human Bel7402 cells after 48 hrs by MTT assay
Cytotoxicity against human Bel7402 cells after 48 hrs by MTT assay
[PMID: 15620246]
BGC-823 IC50
> 5 μg/mL
Compound: 8
Cytotoxicity against human BGC823 cells after 48 hrs by MTT assay
Cytotoxicity against human BGC823 cells after 48 hrs by MTT assay
[PMID: 15620246]
HCT-116 IC50
0.043 μM
Compound: 4
Cytotoxicity against P21 deficient human HCT116 cells after 48 hrs by MTS assay
Cytotoxicity against P21 deficient human HCT116 cells after 48 hrs by MTS assay
[PMID: 11858759]
HCT-116 IC50
0.65 μM
Compound: 4
Cytotoxicity against P21+ wild type human HCT116 cells after 48 hrs by MTS assay
Cytotoxicity against P21+ wild type human HCT116 cells after 48 hrs by MTS assay
[PMID: 11858759]
HCT-116 IC50
7.25 μM
Compound: 4
Cytotoxicity against P53+ wild type human HCT116 cells after 48 hrs by MTS assay
Cytotoxicity against P53+ wild type human HCT116 cells after 48 hrs by MTS assay
[PMID: 11858759]
HCT-116 IC50
8.23 μM
Compound: 4
Cytotoxicity against P53 deficient human HCT116 cells after 48 hrs by MTS assay
Cytotoxicity against P53 deficient human HCT116 cells after 48 hrs by MTS assay
[PMID: 11858759]
HeLa IC50
> 5 μg/mL
Compound: 8
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
[PMID: 15620246]
HL-60 IC50
0.2 μg/mL
Compound: 8
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
[PMID: 15620246]
Molecular Weight

462.62

Formula

C30H38O4
CAS No.
SMILES

C[C@@]12[C@](CC(/C2=C(C)\C=C\C=C(C(O3)=CC=C(C)C3=O)/C)=O)([H])[C@@]4([C@@](C(C)(C(CC4)=O)C)([H])CC1)C
Structure Classification
Initial Source

Jaspis stellifera
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Stellettin B Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Stellettin B184885-91-4AutophagyApoptosisPI3KAktmTORFAKPhosphoinositide 3-kinasePKBProtein kinase BMammalian target of RapamycinPTK2 protein tyrosine kinase 2PTK2Focal adhesion kinaseapoptosisautophagyFAK/PI3K/AKT/mTORtumorInhibitorinhibitorinhibit

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