2. Anti-infection Apoptosis
  3. Bacterial HIV Apoptosis
  4. Aeroplysinin 1

Aeroplysinin 1  (Synonyms: (+)-Aeroplysinin-1)

Cat. No.: HY-19827 Purity: 95.0%
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Aeroplysinin 1 ((+)-Aeroplysinin-1), a secondary metabolite isolated from marine sponges, shows potent antibiotic effects on Gram-positive bacteria and exerts antiviral activity against HIV-1 (IC50=14.6 μM). Aeroplysinin 1 has anti-inflammatory, anti-angiogenic and anti-tumor activities. Aeroplysinin 1 induces apoptosis in endothelial cells.

For research use only. We do not sell to patients.

Aeroplysinin 1 Chemical Structure

Aeroplysinin 1 Chemical Structure

CAS No. : 28656-91-9

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100 μg USD 270 In-stock

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Based on 1 publication(s) in Google Scholar

Aeroplysinin 1 Related Antibodies

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Description

Aeroplysinin 1 ((+)-Aeroplysinin-1), a secondary metabolite isolated from marine sponges, shows potent antibiotic effects on Gram-positive bacteria and exerts antiviral activity against HIV-1 (IC50=14.6 μM). Aeroplysinin 1 has anti-inflammatory, anti-angiogenic and anti-tumor activities. Aeroplysinin 1 induces apoptosis in endothelial cells[1][2].

IC50 & Target[1]

Bacterial

 

HIV-1

14.6 μM (IC50)

Apoptosis

 

Cellular Effect
Cell Line Type Value Description References
HeLa S3 IC50
18.8 μM
Compound: 1, aeroplysinin-1
Cytotoxicity against human HeLaS3 cells after 2 hrs by MTT assay
Cytotoxicity against human HeLaS3 cells after 2 hrs by MTT assay
[PMID: 8786366]
HeLa S3 IC50
2 μM
Compound: 1, aeroplysinin-1
Dose enhancement factor, ratio of IC50 for human HeLaS3 cells after 4 days to IC50 for buthionine sulfoximine-pretreated human HeLaS3 cells after 4 days by MTT assay
Dose enhancement factor, ratio of IC50 for human HeLaS3 cells after 4 days to IC50 for buthionine sulfoximine-pretreated human HeLaS3 cells after 4 days by MTT assay
[PMID: 8786366]
HeLa S3 IC50
2.8 μM
Compound: 1, aeroplysinin-1
Cytotoxicity against buthionine sulfoximine-pretreated human HeLaS3 cells after 4 days by MTT assay
Cytotoxicity against buthionine sulfoximine-pretreated human HeLaS3 cells after 4 days by MTT assay
[PMID: 8786366]
HeLa S3 IC50
27.5 μM
Compound: 1, aeroplysinin-1
Cytotoxicity against human HeLaS3 cells after 2 weeks by clonogenic assay
Cytotoxicity against human HeLaS3 cells after 2 weeks by clonogenic assay
[PMID: 8786366]
HeLa S3 IC50
3.5 μM
Compound: 1, aeroplysinin-1
Dose enhancement factor, ratio of IC50 for human HeLaS3 cells after 2 hrs to IC50 for buthionine sulfoximine-pretreated human HeLaS3 cells after 2 hrs by MTT assay
Dose enhancement factor, ratio of IC50 for human HeLaS3 cells after 2 hrs to IC50 for buthionine sulfoximine-pretreated human HeLaS3 cells after 2 hrs by MTT assay
[PMID: 8786366]
HeLa S3 IC50
5.4 μM
Compound: 1, aeroplysinin-1
Cytotoxicity against buthionine sulfoximine-pretreated human HeLaS3 cells after 2 hrs by MTT assay
Cytotoxicity against buthionine sulfoximine-pretreated human HeLaS3 cells after 2 hrs by MTT assay
[PMID: 8786366]
HeLa S3 IC50
5.6 μM
Compound: 1, aeroplysinin-1
Cytotoxicity against human HeLaS3 cells after 4 days by MTT assay
Cytotoxicity against human HeLaS3 cells after 4 days by MTT assay
[PMID: 8786366]
In Vitro

Aeroplysinin 1 shows anti-proliferative effect against tumor cells (HT-1080, HTC-116, HeLa, THP-1, NOMO-1 and HL-60 cells), with IC50s ranging from 2.3 to 17 μM[1].
Aeroplysinin-1 also exhibits an antiviral activity toward HIV-1 caused by inhibition of its reverse transcriptase activity[1].
Aeroplysinin 1 inhibits P. phosphoreum, C. wailesii, P. minimum and HIV with IC50s of 3.5, 5.6, 7.0 and 14.6 μM[1].
Aeroplysinin 1 inhibits human endothelial cells (EVLC-2, HMEC, RF-24, and HUVEC cells), with IC50s ranging from 2.6 to 4.7 μM[2].
(+)-Aeroplysinin-1 (0.25-0.5 μM) blocks the EGF-dependent proliferation of both MCF-7 and ZR-75-1 human breast cancer cells and inhibits the ligand-induced endocytosis of the EGF receptor in vitro[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Aeroplysinin 1 Related Antibodies
Molecular Weight

338.98

Formula

C9H9Br2NO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N#CC[C@]1(O)C=C(Br)C(OC)=C(Br)[C@@H]1O
Structure Classification
Initial Source

marine sponge
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 3.39 mg/mL (10.00 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9500 mL 14.7501 mL 29.5003 mL
5 mM 0.5900 mL 2.9500 mL 5.9001 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 95.0%

SDS (252 KB)

COA (251 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9500 mL 14.7501 mL 29.5003 mL 73.7507 mL
5 mM 0.5900 mL 2.9500 mL 5.9001 mL 14.7501 mL
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Aeroplysinin 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aeroplysinin 128656-91-9(+)-Aeroplysinin-1Aeroplysinin1Aeroplysinin-1BacterialHIVApoptosisHuman immunodeficiency virussecondarymetabolitevirusangiogenicinfectionproliferationtumorInhibitorinhibitorinhibit

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