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  2. Marine natural products Alkaloids
  3. Sponge Pyridine Alkaloids
  4. Amphimedine

Amphimedine is a polycyclic alkaloid isolated from the marine sponge Amphimedon sp. and belongs to the pyridoindole alkaloid class. Amphimedine has cytotoxic activity and has been studied as an anticancer metabolite along with neoamphimedine. Studies have shown that deoxyamphimedine damages DNA by generating reactive oxygen species, a mechanism different from that of amphimedine.

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Amphimedine Chemical Structure

Amphimedine Chemical Structure

CAS No. : 86047-14-5

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Description

Amphimedine is a polycyclic alkaloid isolated from the marine sponge Amphimedon sp. and belongs to the pyridoindole alkaloid class. Amphimedine has cytotoxic activity and has been studied as an anticancer metabolite along with neoamphimedine. Studies have shown that deoxyamphimedine damages DNA by generating reactive oxygen species, a mechanism different from that of amphimedine.

Molecular Weight

313.31

Formula

C19H11N3O2

CAS No.
SMILES

O=C(C1=NC=CC2=C3C=CC=CC3=NC(C4=CC5=O)=C12)C4=CN5C

Structure Classification
Initial Source

Xestospongia sponges

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Amphimedine
Cat. No.:
HY-121014
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