2. Apoptosis Autophagy Metabolic Enzyme/Protease Immunology/Inflammation NF-κB Cell Cycle/DNA Damage
  3. Apoptosis Autophagy Reactive Oxygen Species CDK
  4. Fascaplysin

Fascaplysin is an antimicrobial and cytotoxic red pigment, that can come from the marine sponge (Fascaplysinopsis sp.). Fascaplysin has been synthesized in seven steps from indole (65% yield). Fascaplysin can induces apoptosis and autophagy in human leukemia HL-60 cells. Fascaplysin shows anti-tumor activity.

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Fascaplysin Chemical Structure

Fascaplysin Chemical Structure

CAS No. : 114719-57-2

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Based on 1 publication(s) in Google Scholar

Fascaplysin Related Antibodies

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

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Description

Fascaplysin is an antimicrobial and cytotoxic red pigment, that can come from the marine sponge (Fascaplysinopsis sp.). Fascaplysin has been synthesized in seven steps from indole (65% yield). Fascaplysin can induces apoptosis and autophagy in human leukemia HL-60 cells. Fascaplysin shows anti-tumor activity[1][2].

IC50 & Target

CDK4

 

Cellular Effect
Cell Line Type Value Description References
A549 IC50
0.69 μM
Compound: 2
Growth inhibition of p53+, pRb+ human A549 cells after 48 hrs by MTT assay
Growth inhibition of p53+, pRb+ human A549 cells after 48 hrs by MTT assay
[PMID: 25368960]
Calu-1 IC50
1.3 μM
Compound: 2
Growth inhibition of p53 null, pRb+ human Calu1 cells after 48 hrs by MTT assay
Growth inhibition of p53 null, pRb+ human Calu1 cells after 48 hrs by MTT assay
[PMID: 25368960]
LS174T IC50
0.88 μM
Compound: 2
Growth inhibition of p53+, pRb+ human LS 174T cells after 48 hrs by MTT assay
Growth inhibition of p53+, pRb+ human LS 174T cells after 48 hrs by MTT assay
[PMID: 25368960]
PC-3 IC50
0.92 μM
Compound: 2
Growth inhibition of p53 null,pRb+ human PC3 cells after 48 hrs by MTT assay
Growth inhibition of p53 null,pRb+ human PC3 cells after 48 hrs by MTT assay
[PMID: 25368960]
Sf9 IC50
0.35 μM
Compound: Fascaplysin
Inhibition of CDK4/Cyclin D (unknown origin) expressed in baculovirus infected insect Sf9 cells using human pRB as substrate in presence of [gamma-32P]ATP
Inhibition of CDK4/Cyclin D (unknown origin) expressed in baculovirus infected insect Sf9 cells using human pRB as substrate in presence of [gamma-32P]ATP
[PMID: 26741853]
Sf9 IC50
0.55 μM
Compound: 4
Inhibition of human CDK4/ Cyclin D1 catalytic subunit expressed in Sf9 insect cells assessed as GST-RB152 fusion protein phosphorylation-associated depletion in ATP level by luminescence assay
Inhibition of human CDK4/ Cyclin D1 catalytic subunit expressed in Sf9 insect cells assessed as GST-RB152 fusion protein phosphorylation-associated depletion in ATP level by luminescence assay
[PMID: 19632122]
Sf9 IC50
500 μM
Compound: 4
Inhibition of human CDK2/ Cyclin A catalytic subunit expressed in Sf9 insect cells assessed as histone H1 phosphorylation-associated depletion in ATP level by luminescence assay
Inhibition of human CDK2/ Cyclin A catalytic subunit expressed in Sf9 insect cells assessed as histone H1 phosphorylation-associated depletion in ATP level by luminescence assay
[PMID: 19632122]
In Vitro

Fascaplysin induces autophagy as a cytoprotective response via ROS and p8 in vascular endothelial cells (VECs)[2].
Fascaplysin targets metabolic activity of the prostate cancer cells, without disrupting cell membrane's integrity[2].
. Fascaplysin induces caspase mediated crosstalk between apoptosis and autophagy through the inhibition of PI3K/AKT/mTOR signaling cascade in human leukemia HL-60 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fascaplysin Related Antibodies
In Vivo

Fascaplysin suppresses the growth of S180 cell-implanted tumors in vivo[2]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

306.75

Formula

C18H11ClN2O
CAS No.
SMILES

O=C1C2=C3NC4=C(C=CC=C4)C3=CC=[N+]2C5=C1C=CC=C5.[Cl-]
Structure Classification
Initial Source

sponge
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Fascaplysin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fascaplysin114719-57-2ApoptosisAutophagyReactive Oxygen SpeciesCDKCyclin dependent kinaseS180 cellHL-60 cellsVascular endothelial cells (VECs)LeukemiaAnti-tumor activityInhibitorinhibitorinhibit

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