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Results for "

ryanodine receptors

" in MedChemExpress (MCE) Product Catalog:

36

Inhibitors & Agonists

6

Peptides

6

Natural
Products

3

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W339331
    Flubendiamide

    NNI-0001

    		 Others Others
    Flubendiamide is a 1,2-diamide insecticide via action mode of action action by activating the ryanodine receptor .
    Flubendiamide
  • HY-113920A
    Azumolene

    EU4093 free base

    		 Calcium Channel Metabolic Disease
    Azumolene (EU4093 free base), a Dantrolene analog, is a muscle relaxant. Azumolene is a ryanodine receptor (RyR) modulator and inhibits the calcium-release through ryanodine receptor. Azumolene can be used for malignant hyperthermia research .
    Azumolene
  • HY-155394
    RyRs activator 5

    		Others Metabolic Disease
    RyRs activator 5 (Compd A-1) is an active ryanodine receptor agonist against Spodoptera frugiperda .
    RyRs activator 5
  • HY-W339331R
    Flubendiamide (Standard)

    		Others Others
    Flubendiamide (Standard) is the analytical standard of Flubendiamide. This product is intended for research and analytical applications. Flubendiamide is a 1,2-diamide insecticide via action mode of action action by activating the ryanodine receptor .
    Flubendiamide (Standard)
  • HY-146109
    RyRs activator 1

    		Parasite Infection
    RyRs activator 1 (compound 7f) is a potent activator of ryanodine receptors (RyRs). RyRs activator 1 at 0.5 mg/L displays 100% larvicidal activity. The larvicidal activity of RyRs activator 1 is 90% at 0.01 mg/L .
    RyRs activator 1
  • HY-155334
    RyRs activator 4

    		Others Others
    RyRs activator 4 (compound B18) is an insect ryanodine receptor activator. RyRs activator 4 has a larvicidal activity of Mythimna separata with an LC50 value of 1.32 mg/L .
    RyRs activator 4
  • HY-110312
    JTV-519 fumarate

    K201 fumarate

    		 Others Cardiovascular Disease
    JTV-519 fumarate (K201 fumarate) is a Ca 2+-dependent blocker of sarcoplasmic reticulum Ca 2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. JTV-519 fumarate is a cardioprotective agent with antiarrhythmic effects .
    JTV-519 fumarate
  • HY-146110
    RyRs activator 2

    		Parasite Infection
    RyRs activator 2 (compound 7o) is a potent activator of ryanodine receptors (RyRs). RyRs activator 2 is 30% larvicidal activity, comparable to chlorantraniliprole (30%) and better than cyantraniliprole (10%) .
    RyRs activator 2
  • HY-163157
    Insecticidal agent 7

    		Parasite Others
    Insecticidal agent 7 (Compound 21m) is an insecticide that targets the insect ryanodine receptors (RyRs) with a LC50 of 0.0937 mg/L for the Plutella xylostella. Insecticidal agent 7 (Compound 21m) exhibits good selectivity and low toxicity towards non-target organisms .
    Insecticidal agent 7
  • HY-156082
    RyRs activator 3

    		Parasite Calcium Channel Others
    RyRs activator 3 (compound A4) is an effective insecticide against diamondback moths (M. separata) and diamondback moths (P. xylostella). The LC50 value of RyRs activator 3 against diamondback moth is 3.27 mg/L. RyRs activator 3 can bind to ryanodine receptor, increase cytoplasmic Ca2+ concentration, and produce biological toxicity .
    RyRs activator 3
  • HY-N7491A
    Ent-(+)-Verticilide

    		Calcium Channel Cancer
    ent-(+)-verticilide is a potent and selective inhibitor of cardiac ryanodine receptor (RyR2) calcium release channels with antiarrhythmic activity. ent-(+)-verticilide inhibits RyR2-mediated diastolic Ca 2+?leak and exhibits higher potency and a distinct mechanism of action compared with theDantrolene and Tetracaine.?ent-(+)-verticilide is a useful tool to investigate the therapeutic potential of targeting RyR2 hyperactivity in heart and brain pathologies .
    Ent-(+)-Verticilide
  • HY-N7491
    Verticilide

    		Calcium Channel Inflammation/Immunology
    Verticilide is a ryanodine-binding inhibitor and inhibits ryanodine binding to ryanodine receptors in the cockroach at an IC50 value of 4.2 ?μM (whereas inhibition against mouse ryanodine receptors was weak (IC50=53.9?μM)) .
    Verticilide
  • HY-103306
    Ryanodine
    4 Publications Verification

    		 Others Neurological Disease
    Ryanodine is a cell permeant ryanodine receptor modulator. Ryanodine can either stimulate or inhibit Ryanodine-mediated Ca 2+ release depending on its concentrations. Poisonous diterpenoid found in Ryania speciosa.
    Ryanodine
  • HY-12542
    Dantrolene
    Maximum Cited Publications
    8 Publications Verification

    F 368

    		 Calcium Channel Autophagy Neurological Disease Inflammation/Immunology
    Dantrolene is an orally active, non-competitive glutathione reductase inhibitor with a Ki of 111.6 μM and an IC50 of 52.3 μM. Dantrolene is a ryanodine receptor (RyR) antagonist and Ca2+ signaling stabilizer. Dantrolene is a direct-acting skeletal muscle relaxant. Dantrolene can be used for the research of muscle spasticity, malignant hyperthermia, Huntington's disease and other neuroleptic malignant syndrome .
    Dantrolene
  • HY-159502
    Surlorian

    		Parasite Infection
    Surlorian is a ryanodine receptor (RyR) stabilizer .
    Surlorian
  • HY-12542A
    Dantrolene sodium hemiheptahydrate
    Maximum Cited Publications
    8 Publications Verification

    Dantrolene sodium hydrate

    		 Calcium Channel Autophagy Others
    Dantrolene sodium hemiheptahydrate is an orally active, non-competitive glutathione reductase inhibitor with a Ki of 111.6 μM and an IC50 of 52.3 μM. Dantrolene sodium hemiheptahydrate is a ryanodine receptor (RyR) antagonist and Ca2+ signaling stabilizer. Dantrolene sodium hemiheptahydrate is a direct-acting skeletal muscle relaxant. Dantrolene sodium hemiheptahydrate can be used for the research of muscle spasticity, malignant hyperthermia, Huntington's disease and other neuroleptic malignant syndrome .
    Dantrolene sodium hemiheptahydrate
  • HY-12542R
    Dantrolene (Standard)

    		Calcium Channel Autophagy Neurological Disease Inflammation/Immunology
    Dantrolene (Standard) is the analytical standard of Dantrolene. This product is intended for research and analytical applications. Dantrolene is an orally active, non-competitive glutathione reductase inhibitor with a Ki of 111.6 μM and an IC50 of 52.3 μM. Dantrolene is a ryanodine receptor (RyR) antagonist and Ca2+ signaling stabilizer. Dantrolene is a direct-acting skeletal muscle relaxant. Dantrolene can be used for the research of muscle spasticity, malignant hyperthermia, Huntington's disease and other neuroleptic malignant syndrome .
    Dantrolene (Standard)
  • HY-12542AR
    Dantrolene sodium hemiheptahydrate (Standard)

    		Calcium Channel Autophagy Others
    Dantrolene (sodium hemiheptahydrate) (Standard) is the analytical standard of Dantrolene (sodium hemiheptahydrate). This product is intended for research and analytical applications. Dantrolene sodium hemiheptahydrate is an orally active, non-competitive glutathione reductase inhibitor with a Ki of 111.6 μM and an IC50 of 52.3 μM. Dantrolene sodium hemiheptahydrate is a ryanodine receptor (RyR) antagonist and Ca2+ signaling stabilizer. Dantrolene sodium hemiheptahydrate is a direct-acting skeletal muscle relaxant. Dantrolene sodium hemiheptahydrate can be used for the research of muscle spasticity, malignant hyperthermia, Huntington's disease and other neuroleptic malignant syndrome .
    Dantrolene sodium hemiheptahydrate (Standard)
  • HY-112820
    Chlorantraniliprole
    1 Publications Verification

    		 Others Others
    Chlorantraniliprole is an insecticide that potently and selectively activates insect ryanodine receptor, with EC50s of 40 nM and 50 nM for Drosophila melanogaster and H. virescens ryanodine receptor, and ～300-fold more potent than that in the mouse myoblast cell line, C2C12 (EC50, 14 μM).
    Chlorantraniliprole
  • HY-W016498
    Paraxanthine
    2 Publications Verification

    		 Drug Metabolite Endogenous Metabolite Neurological Disease
    Paraxanthine, a caffeine metabolite, provides protection against Dopaminergic cell death via stimulation of Ryanodine Receptor Channels.
    Paraxanthine
  • HY-112820R
    Chlorantraniliprole (Standard)

    		Others Others
    Chlorantraniliprole (Standard) is the analytical standard of Chlorantraniliprole. This product is intended for research and analytical applications. Chlorantraniliprole is an insecticide that potently and selectively activates insect ryanodine receptor, with EC50s of 40 nM and 50 nM for Drosophila melanogaster and H. virescens ryanodine receptor, and ～300-fold more potent than that in the mouse myoblast cell line, C2C12 (EC50, 14 μM).
    Chlorantraniliprole (Standard)
  • HY-P5114
    Maurocalcine

    		Calcium Channel Others
    Maurocalcine is an agonist of ryanodine receptor (RyR) channel types 1, 2 and 3 with cellular permeability. Maurocalcine induces [ 3H]ryanodine binding on RyR1 with an EC50 value of 2558 nM. Maurocalcine exhibits a apparent affinity of 14 nM for RyR2. Maurocalcine can be applied to in vivo cell tracking or other cell imaging techniques .
    Maurocalcine
  • HY-W016498S
    Paraxanthine-d6

    		Isotope-Labeled Compounds Endogenous Metabolite Neurological Disease
    Paraxanthine-d6 is the deuterium labeled Paraxanthine. Paraxanthine, a caffeine metabolite, provides protection against Dopaminergic cell death via stimulation of Ryanodine Receptor Channels.
    Paraxanthine-d6
  • HY-P5114A
    Maurocalcine TFA

    		Calcium Channel Others
    Maurocalcine TFA is an agonist of ryanodine receptor (RyR) channel types 1, 2 and 3 with cellular permeability. Maurocalcine TFA induces [ 3H]ryanodine binding on RyR1 with an EC50 value of 2558 nM. Maurocalcine TFA exhibits a apparent affinity of 14 nM for RyR2. Maurocalcine TFA can be applied to in vivo cell tracking or other cell imaging techniques .
    Maurocalcine TFA
  • HY-W016498R
    Paraxanthine (Standard)

    		Drug Metabolite Endogenous Metabolite Neurological Disease
    Paraxanthine (Standard) is the analytical standard of Paraxanthine. This product is intended for research and analytical applications. Paraxanthine, a caffeine metabolite, provides protection against Dopaminergic cell death via stimulation of Ryanodine Receptor Channels.
    Paraxanthine (Standard)
  • HY-P3037
    Imperatoxin A

    		Calcium Channel Neurological Disease
    Imperatoxin A, a peptide toxin derived from the venom of the African scorpion Pandinus imperator, activator of Ca 2+-release channels/ryanodine receptors (RyRs) enhances the influx of Ca 2+ from the sarcoplasmatic reticulum into the cell .
    Imperatoxin A
  • HY-138806
    PAQ

    		Others Neurological Disease
    PAQ (Compound 4c) is a quinoxaline derivative. PAQ is an orally active neuroprotective agent, which targets dopamine (DA) neurons and activates reticulum endoplasmic ryanodine receptor (RyR) channels, without effects on glia cells .
    PAQ
  • HY-15293
    JTV-519

    K201

    		 Calcium Channel Cardiovascular Disease
    JTV-519 (K201) is a Ca 2+-dependent blocker of sarcoplasmic reticulum Ca 2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties .
    JTV-519
  • HY-W016498S1
    Paraxanthine-13C4,15N3

    		Isotope-Labeled Compounds Endogenous Metabolite Neurological Disease
    Paraxanthine- 13C4, 15N3 is the 13C-labeled and 15N-labeled Paraxanthine. Paraxanthine, a caffeine metabolite, provides protection against Dopaminergic cell death via stimulation of Ryanodine Receptor Channels.
    Paraxanthine-13C4,15N3
  • HY-15293B
    JTV-519 hemifumarate

    K201 hemifumarate

    		 Calcium Channel Cardiovascular Disease
    JTV-519 hemifumarate (K201 hemifumarate) is a Ca 2+-dependent blocker of sarcoplasmic reticulum Ca 2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties .
    JTV-519 hemifumarate
  • HY-15293A
    JTV-519 free base

    K201 free base

    		 Calcium Channel Cardiovascular Disease
    JTV-519 free base (K201 free base) is a Ca 2+-dependent blocker of sarcoplasmic reticulum Ca 2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties .
    JTV-519 free base
  • HY-P3037A
    Imperatoxin A TFA

    		Calcium Channel Neurological Disease
    Imperatoxin A TFA is a peptide toxin derived from the venom of the African scorpion Pandinus imperator. Imperatoxin A TFA is a Ca 2+-release channels/ryanodine receptors (RyRs) activator. Imperatoxin A TFA enhances the influx of Ca 2+ from the sarcoplasmatic reticulum into the cell .
    Imperatoxin A TFA
  • HY-149697
    Insecticidal agent 6

    		Parasite Others
    Insecticidal agent 6 (Compound Im) is an insect ryanodine receptors (RyRs) inhibitor, with an EC50 value of 0.6308 µM against S. frugiperda RyRs. Insecticidal agent 6 has excellent insecticidal activity against lepidopteran pests and can be used for research on pests and diseases .
    Insecticidal agent 6
  • HY-N7395
    Cyclic ADP-​ribose

    cADPR

    		 Calcium Channel TRP Channel Endogenous Metabolite Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Endocrinology
    Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD + by an ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels .
    Cyclic ADP-​ribose
  • HY-N7395A
    Cyclic ADP-​ribose ammonium

    cADPR ammonium

    		 Calcium Channel TRP Channel Endogenous Metabolite Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Endocrinology
    Cyclic ADP-ribose ammonium (cADPR ammonium) is a potent second messenger for calcium mobilization that is synthesized from NAD + by an ADP-ribosyl cyclase. Cyclic ADP-ribose ammonium increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels .
    Cyclic ADP-​ribose ammonium
  • HY-12542S
    Dantrolene-13C3

    F 368-13C3

    		 Isotope-Labeled Compounds Glutathione Reductase Neurological Disease Inflammation/Immunology
    Dantrolene- 13C3 is the 13C3 labeled Dantrolene. Dantrolene (F368), a muscle relaxant, non-competitively inhibits human erythrocyte glutathione reductase. Ki and IC50 values are 111.6 μM and 52.3 μM, respectively. Dantrolene is a ryanodine receptor antagonist and Ca2+ signaling stabilizer. Dantrolene can be used for the research of muscle spasticity, malignant hyperthermia, Huntington's disease and other neuroleptic malignant syndrome.
    Dantrolene-13C3

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