2. Neuronal Signaling Membrane Transporter/Ion Channel Metabolic Enzyme/Protease
  3. Calcium Channel TRP Channel Endogenous Metabolite
  4. Cyclic ADP-​ribose

Cyclic ADP-​ribose  (Synonyms: cADPR)

Cat. No.: HY-N7395 Purity: 92%
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Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD+ by an ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels.

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Cyclic ADP-​ribose Chemical Structure

Cyclic ADP-​ribose Chemical Structure

CAS No. : 119340-53-3

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500 μg USD 760 In-stock

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Based on 1 publication(s) in Google Scholar

Other Forms of Cyclic ADP-​ribose:

Cyclic ADP-​ribose Related Antibodies

Top Publications Citing Use of Products

View All Calcium Channel Isoform Specific Products:

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

View All TRP Channel Isoform Specific Products:

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TRPC TRPM TRPV TRPA TRPML

  • Biological Activity

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Description

Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD+ by an ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels[1][2][3].

IC50 & Target

Calcium mobilization[1]
TRPM2 channels[3]
Endogenous metabolite[1]
In Vitro

cADPR (20 nM) elicits a large rapid Ca2+ release in sea urchin eggs homogenates[1].
cADPR (100 μM; 10 min) induces a sustained elevation of intracellular calcium concentration in a subset (64%) of cultured astrocytes[4].
cADPR (100 μM) and heat (35-38.5 ℃) stimulates oxytocin OT release from the isolated hypothalami of male mice in culture[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cyclic ADP-​ribose Related Antibodies
In Vivo

cADPR (100 μM; push-pull type of brain microperfusion) elevats OT concentrations in ordinate or subordinate mice[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

541.30

Formula

C15H21N5O13P2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@H](O)[C@H](N(C=N2)C3=C2C(N(C=N3)[C@@H]([C@H](O)[C@@H]4O)O[C@@H]4CO5)=N)O[C@@H]1COP(OP5(O)=O)(O)=O
Structure Classification
Initial Source
Shipping

Shipping with dry ice.
Storage

-80°C
Solvent & Solubility
In Vitro: 

H2O : 5 mg/mL (9.24 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8474 mL 9.2370 mL 18.4740 mL
5 mM 0.3695 mL 1.8474 mL 3.6948 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months. When stored at -80°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥96.0%

SDS (393 KB)

COA (261 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months. When stored at -80°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.8474 mL 9.2370 mL 18.4740 mL 46.1851 mL
5 mM 0.3695 mL 1.8474 mL 3.6948 mL 9.2370 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Cyclic ADP-​ribose Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclic ADP-​ribose119340-53-3cADPRCalcium ChannelTRP ChannelEndogenous MetaboliteCa2+ channelsCa channelsTransient receptor potential channelsCD38calcium-mobilizingmessengerTRPM2RyanodineendoplasmicreticulumdifferentiationinflammatoryimmuneInhibitorinhibitorinhibit

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