Paraxanthine-¹³C₄,¹⁵N₃

Name: Paraxanthine- 13 C 4 , 15 N 3
Brand: MedChemExpress
SKU: HY-W016498S1
Rating: 4.5 (1 reviews)

Cat. No.: HY-W016498S1 Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

Paraxanthine-¹³C₄,¹⁵N₃ is the ¹³C-labeled and ¹⁵N-labeled Paraxanthine. Paraxanthine, a caffeine metabolite, provides protection against Dopaminergic cell death via stimulation of Ryanodine Receptor Channels.

For research use only. We do not sell to patients.

Paraxanthine-<sup>13</sup>C<sub>4</sub>,<sup>15</sup>N<sub>3</sub> Chemical Structure

Paraxanthine-¹³C₄,¹⁵N₃ Chemical Structure

CAS No. : 1173018-79-5

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	Get quote
10 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Paraxanthine-¹³C₄,¹⁵N₃:

Paraxanthine Get quote

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

187.11

Formula

C₃¹³C₄H₈N¹⁵N₃O₂

CAS No.

1173018-79-5

Appearance

Solid

Color

White to light yellow

SMILES

CN1C=[15N][13C]([15NH][13C]2=O)=[13C]1[13C]([15N]2C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 30 mg/mL (160.33 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF : ≥ 20 mg/mL (106.89 mM)

Ethanol : ≥ 0.5 mg/mL (2.67 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.3444 mL	26.7222 mL	53.4445 mL
5 mM	1.0689 mL	5.3444 mL	10.6889 mL
10 mM	0.5344 mL	2.6722 mL	5.3444 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (279 KB) SDS (252 KB)

COA (257 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Guerreiro S, et al. Paraxanthine, the primary metabolite of caffeine, provides protection against dopaminergic cell death via stimulation of ryanodine receptor channels. Mol Pharmacol. 2008 Oct;74(4):980-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Ethanol / DMF / DMSO	1 mM	5.3444 mL	26.7222 mL	53.4445 mL	133.6112 mL
DMF / DMSO	5 mM	1.0689 mL	5.3444 mL	10.6889 mL	26.7222 mL
	10 mM	0.5344 mL	2.6722 mL	5.3444 mL	13.3611 mL
	15 mM	0.3563 mL	1.7815 mL	3.5630 mL	8.9074 mL
	20 mM	0.2672 mL	1.3361 mL	2.6722 mL	6.6806 mL
	25 mM	0.2138 mL	1.0689 mL	2.1378 mL	5.3444 mL
	30 mM	0.1781 mL	0.8907 mL	1.7815 mL	4.4537 mL
	40 mM	0.1336 mL	0.6681 mL	1.3361 mL	3.3403 mL
	50 mM	0.1069 mL	0.5344 mL	1.0689 mL	2.6722 mL
	60 mM	0.0891 mL	0.4454 mL	0.8907 mL	2.2269 mL
	80 mM	0.0668 mL	0.3340 mL	0.6681 mL	1.6701 mL
	100 mM	0.0534 mL	0.2672 mL	0.5344 mL	1.3361 mL