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steroidal saponins

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Amyloid-β (1) Apoptosis (5) Autophagy (4) Bacterial (1) Bcl-2 Family (1) Caspase (1) COX (1) Endogenous Metabolite (3) ERK (1) Fungal (2) MEK (1) MicroRNA (2) NF-κB (1) NO Synthase (1) P-glycoprotein (1) p38 MAPK (1) PARP (1) Reactive Oxygen Species (1) STAT (2)
By Research Areas:	Cancer (13) Cardiovascular Disease (3) Infection (3) Inflammation/Immunology (6) Metabolic Disease (3) Neurological Disease (3)

Inhibitors & Agonists

Natural
Products

Targets Recommended: Steroid Sulfatase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N5135

Liriopesides B Nolinospiroside F	Others	Others
Liriopesides B (Nolinospiroside F) is a steroidal saponin isolated from Ophiopogon japonicas. Liriopesides B has anti-oxidative and anti-aging effects .

HY-N2386

Polyphyllin E	Others	Others
Polyphyllin E is a steroidal saponin that can be isolated from Paris polyphylla .

HY-N12355

Disporoside C	Others	Others
Disporoside C is a steroidal saponin can be isolated from Disporopsis pernyi .

HY-N4272

Protodeltonin	Others	Cancer
Protodeltonin is a steroidal saponin from Dioscorea zingiberensis Wright, with anti-proliferation activity .

HY-N12065

Parisyunnanoside H	Others	Others
Parisyunnanoside H is a steroidal saponin isolated from Paris polyphylla Smith var. yunnanensis* .*

HY-N11983

(25R)-Ruscogenin-3-yl α-L-rhamnopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→4)]-β-D-glucopyranoside	Others	Others
(25R)-Ruscogenin-3-yl α-L-rhamnopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→4)]-β-D-glucopyranoside (compound 1) is a steroidal saponin , can be isolated from the roots of Ophiopogon japonicus .

HY-N7614

Anemarrhenasaponin A2 Schidigerasaponin F2; Timosaponin AII	Others	Cardiovascular Disease
Anemarrhenasaponin A2 (Schidigerasaponin F2) is a steroidal saponin isolated from the rhizomes of Anemarrhena asphodeloides. Anemarrhenasaponin A2 inhibits ADP-induced platelet aggregation .

HY-N3323

Mannioside A	Others	Inflammation/Immunology
Mannioside A is a steroidal saponin. Mannioside A is a nature product that could be isolated from Dracaena mannii. Mannioside A has anti-inflammatory effect .

HY-N8804

Shatavarin IV Asparanin B	Reactive Oxygen Species	Neurological Disease Cancer
Shatavarin IV is a steroidal saponin, that can be isolated from the roots of Asparagus racemosus (Liliaceae). Shatavarin IV shows anticancer activity. Shatavarin IV elicits lifespan extension and alleviates Parkinsonism in Caenorhabditis elegans .

HY-N12128

Ophiopogonin R	Others	Cancer
Ophiopogonin R (compound 3) is a steroid saponin. Ophiopogonin R was isolated and purified from natural ophiopogonin. Ophiopogonin R was not cytotoxic to five human tumor cell lines (HepG2, HLE, BEL7402, BEL7403 and Hela) .

HY-N12002

Diosgenin-3-O-rhamnosyl(1→2)[glucosyl(1→6)]glucoside	Others	Others
Diosgenin-3-O-rhamnosyl(1→2)[glucosyl(1→6)]glucoside (compound 9) is a steroidal saponin, which can be obtained from Paris polyphylla var., Yunnan pine (yunnanensis) Isolated .

HY-N4271

Protogracillin	Others	Cardiovascular Disease
Protogracillin is a steroidal saponin isolated from Dioscorea zingiberensis Wright (DZW). Steroidal saponins from DZW rhizomes have the potential to reduce the risk of cardiovascular diseases by anti-thrombotic action .

HY-N4270

Pseudoprotogracillin	Others	Others
Pseudoprotogracillin is a steroidal saponin isolated Dioscoreae species .

HY-107284

Officinalisinin I	Others	Others
Officinalisinin I is a steroidal saponin, isolated from Anemarrhena asphodeloides.

HY-121593

Ruizgenin	Others	Others
Ruizgenin is a new steroidal saponin diol extracted from Agave lecheguilla.

HY-N13104

Dracaenoside F	Others	Others
Dracaenoside F is a steroidal saponin that can be isolated from Dracaena cochinchinensis .

HY-N6079

Timosaponin A1	Others	Others
Timosaponin A1 is a coprostane type steroidal saponin isolated from Rhizoma Anemarrhenae.

HY-133237

Anemarrhenasaponin III	Others	Others
Anemarrhenasaponin III is a steroidal saponin isolated from the rhizome of Anemarrhena asphodeloides Bunge (Liliaceae) .

HY-N12424

Elephanoside D	Others	Others
Elephanoside D (compound 8) is a steroidal saponin isolated from the stems of Yucca elephantipes Regel.

HY-N13137

Timosaponin N	Others	Metabolic Disease
Timosaponin N is a natural steroidal saponin. Timosaponin N can be used in diabetes-related research .

HY-N5078

Terrestrosin K	Others	Cardiovascular Disease
Terrestrosin K, a steroidal saponin from Tribulus terrestris L., has potential to treat cardiovascular and cerebrovascular diseases .

HY-N2283

Deltonin 1 Publications Verification	ERK Akt Endogenous Metabolite	Cancer
Deltonin, a steroidal saponin, isolated from Dioscorea zingiberensis, has antitumor activity; Deltonin inhibits ERK1/2 and AKT activation.

HY-N5074

Terrestrosin D	Apoptosis	Cancer
Terrestrosin D, a steroidal saponin from Tribulus terrestris L., induces cell cycle arrest and cancer cells apoptosis. Terrestrosin D has antiangiogenic activities .

HY-N0706

Gracillin 1 Publications Verification	Apoptosis Autophagy	Cancer
Gracillin is a steroidal saponin that can be extracted from the roots of the plant and has anti-tumor properties. Gracillin can induce cancer cell apoptosis and autophagy .

HY-N0812

Timosaponin BII Prototimosaponin A III	Amyloid-β	Neurological Disease Inflammation/Immunology Cancer
Timosaponin BII (Prototimosaponin A III) is a steroid saponin found in the rhizomes of Anemarrhena asphodeloides. Timosaponin BII has neuronal protective, anti-inflammatory and antioxidant activities .

HY-N0799

Protodioscin	Endogenous Metabolite	Cancer
Protodioscin, a major steroidal saponin in Trigonella foenum-graecum Linn., has been shown to exhibit multiple biological actions, such as anti-hyperlipidemia, anti-cancer, sexual effects and cardiovascular properties.

HY-N3584

Paris saponin VII 2 Publications Verification Chonglou Saponin VII	Akt p38 MAPK P-glycoprotein Bcl-2 Family Caspase PARP Autophagy Apoptosis	Cancer
Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .

HY-N6806

Timosaponin B III	Others	Neurological Disease Inflammation/Immunology
Timosaponin B III is a major bioactive steroidal saponin isolated from Anemarrhena asphodeloides Bge, and exhibits anti-inflammatory, anti-platelet aggregative and anti-depressive effects .

HY-N1422

Hecogenin	Fungal	Infection Inflammation/Immunology
Hecogenin is a steroid saponin isolated from Agave sisalana and is a selective inhibitor of human UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities, including anti-inflammatory, antifungal and gastroprotective effects .

HY-N0706R

Gracillin (Standard)	Apoptosis Autophagy	Cancer
Gracillin (Standard) is the analytical standard of Gracillin. This product is intended for research and analytical applications. Gracillin is a steroidal saponin that can be extracted from the roots of the plant and has anti-tumor properties. Gracillin can induce cancer cell apoptosis and autophagy .

HY-N0799R

Protodioscin (Standard)	Endogenous Metabolite	Cancer
Protodioscin (Standard) is the analytical standard of Protodioscin. This product is intended for research and analytical applications. Protodioscin, a major steroidal saponin in Trigonella foenum-graecum Linn., has been shown to exhibit multiple biological actions, such as anti-hyperlipidemia, anti-cancer, sexual effects and cardiovascular properties.

HY-N13136

Timosaponin D	Others	Cancer
Timosaponin D, a natural steroid saponin, can be obtained from the rhizome of Anemarrhena asphodeloides. The IC₅₀ values of Timosaponin D against HepG2 and SGC7901 cells are 43.90 and 57.90 μM, respectively. Timosaponin D can be used in anticancer research .

HY-N0177

Diosgenin 5 Publications Verification	STAT MicroRNA	Metabolic Disease
Diosgenin, a steroidal saponin, can inhibit STAT3 signaling pathway . Diosgenin is an exogenous activator of Pdia3/ERp57 . Diosgenin inhibits aortic atherosclerosis progression by suppressing macrophage miR-19b expression .

HY-N1422R

Hecogenin (Standard)	Fungal	Infection Inflammation/Immunology
Hecogenin (Standard) is the analytical standard of Hecogenin. This product is intended for research and analytical applications. Hecogenin is a steroid saponin isolated from Agave sisalana and is a selective inhibitor of human UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities, including anti-inflammatory, antifungal and gastroprotective effects .

HY-N1654

2',3'-Dehydrosalannol	Bacterial	Infection
2',3'-Dehydrosalannol is a potent antibacterial agent. 2',3'-Dehydrosalannol shows antibacterial activity against K. pneumonia ATCC 13883, P. aeruginosa ATCC 27853, S. aureus ATCC 25922, E. coli ATCC 11775, and E. faecalis ATCC 10541, with MIC values of 0.78, 1.56, 1.56, 6.25, and 25 µg/mL, respectively .

HY-N0177R

Diosgenin (Standard)	STAT MicroRNA	Metabolic Disease
Diosgenin (Standard) is the analytical standard of Diosgenin. This product is intended for research and analytical applications. Diosgenin, a steroidal saponin, can inhibit STAT3 signaling pathway . Diosgenin is an exogenous activator of Pdia3/ERp57 . Diosgenin inhibits aortic atherosclerosis progression by suppressing macrophage miR-19b expression .

HY-N0124

Dioscin Maximum Cited Publications 10 Publications Verification Collettiside III; CCRIS 4123	Autophagy Apoptosis	Cancer
Dioscin (CCRIS 4123; Collettiside III) is a natural plant-derived steroidal saponin that has good anti-cancer activity against a variety of cancer cells. Dioscin causes DNA damage and induces apoptosis in HeLa and SiHa cells. Dioscin regulates ROS-mediated DNA damage and mitochondrial signaling pathways, exerting anticancer activity .

HY-N0811

Anemarsaponin B	NO Synthase COX NF-κB MEK	Inflammation/Immunology
Anemarsaponin B is a steroidal saponin. Anemarsaponin B decreases the protein and mRNA levels of iNOS and COX-2. Anemarsaponin B reduces the expressions and productions of pro-inflammatory cytokines, including TNF-a and IL-6. Anemarsaponin B inhibits the nuclear translocation of the p65 subunit of NF-κB by blocking the phosphorylation of IκBα. Anemarsaponin B also inhibits the phosphorylation of MAP kinase kinases 3/6 (MKK3/6) and mixed lineage kinase 3 (MLK3). Anti-inflammatory effect .

Liriopesides B Nolinospiroside F	Structural Classification Liliaceae Classification of Application Fields Anti-aging Source classification Other Diseases Liriope spicata (Thunb.) Lour. Plants Disease Research Fields Steroids	Others
Liriopesides B (Nolinospiroside F) is a steroidal saponin isolated from Ophiopogon japonicas. Liriopesides B has anti-oxidative and anti-aging effects .

Polyphyllin E	Structural Classification Natural Products Source classification Plants Melanthiaceae Paris polyphylla var. yunnanensis (Franch.) Hand.-Mzt.	Others
Polyphyllin E is a steroidal saponin that can be isolated from Paris polyphylla .

Disporoside C	Structural Classification Source classification Disporopsis pernyi (Hua) Diels Plants Steroids Asparagaceae Juss.	Others
Disporoside C is a steroidal saponin can be isolated from Disporopsis pernyi .

Protodeltonin	Liliaceae Lilium longiflorum Thunb. Classification of Application Fields Source classification Plants Disease Research Fields Steroids Cancer	Others
Protodeltonin is a steroidal saponin from Dioscorea zingiberensis Wright, with anti-proliferation activity .

Parisyunnanoside H	Structural Classification Polysaccharides Liliaceae Source classification Paris polyphylla Smith Plants Saccharides	Others
Parisyunnanoside H is a steroidal saponin isolated from Paris polyphylla Smith var. yunnanensis* .*

(25R)-Ruscogenin-3-yl α-L-rhamnopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→4)]-β-D-glucopyranoside	Ophiopogon japonicus (L. f.) Ker-Gawl. Structural Classification Liliaceae Source classification Plants Steroids	Others
(25R)-Ruscogenin-3-yl α-L-rhamnopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→4)]-β-D-glucopyranoside (compound 1) is a steroidal saponin , can be isolated from the roots of Ophiopogon japonicus .

Anemarrhenasaponin A2 Schidigerasaponin F2; Timosaponin AII	Cardiovascular Disease Liliaceae Classification of Application Fields Source classification Anemarrhena asphodeloides Bunge Plants Disease Research Fields Steroids	Others
Anemarrhenasaponin A2 (Schidigerasaponin F2) is a steroidal saponin isolated from the rhizomes of Anemarrhena asphodeloides. Anemarrhenasaponin A2 inhibits ADP-induced platelet aggregation .

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steroidal saponins

Inhibitors & Agonists

NaturalProducts

Natural
Products