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  4. Hecogenin

Hecogenin is a steroid saponin isolated from Agave sisalana and is a selective inhibitor of human UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities, including anti-inflammatory, antifungal and gastroprotective effects.

For research use only. We do not sell to patients.

Hecogenin Chemical Structure

Hecogenin Chemical Structure

CAS No. : 467-55-0

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10 mg USD 60 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Hecogenin:

Hecogenin Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Hecogenin is a steroid saponin isolated from Agave sisalana and is a selective inhibitor of human UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities, including anti-inflammatory, antifungal and gastroprotective effects[1].

IC50 & Target

Human UDP-glucuronosyltransferases[1]
Cellular Effect
Cell Line Type Value Description References
A549 IC50
> 40 μM
Compound: Hecogenin
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 33735799]
BT-474 IC50
38.2 μM
Compound: 1
Antiproliferative activity against human BT474 cells after 72 hrs by MTT assay
Antiproliferative activity against human BT474 cells after 72 hrs by MTT assay
[PMID: 29066046]
HT-29 IC50
> 40 μM
Compound: Hecogenin
Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 33735799]
HUVEC IC50
> 100 μM
Compound: Hecogenin
Cytotoxicity against human HUVEC cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human HUVEC cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 33735799]
MCF7 IC50
28.7 μM
Compound: Hecogenin
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 33735799]
MCF7 IC50
31 μM
Compound: 1
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 29066046]
MDA-MB-231 IC50
28.7 μM
Compound: 1
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
[PMID: 29066046]
MDA-MB-231 IC50
31.21 μM
Compound: Hecogenin
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 33735799]
MDA-MB-231 IC50
37.1 μM
Compound: 1
Antiinvasive activity against human MDA-MB-231 cells after 24 hrs by cell invasion assay
Antiinvasive activity against human MDA-MB-231 cells after 24 hrs by cell invasion assay
[PMID: 29066046]
MDA-MB-468 IC50
35.2 μM
Compound: 1
Antiproliferative activity against human MDA-MB-468 cells after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-468 cells after 72 hrs by MTT assay
[PMID: 29066046]
SK-BR-3 IC50
33.3 μM
Compound: 1
Antiproliferative activity against human SKBR3 cells after 72 hrs by MTT assay
Antiproliferative activity against human SKBR3 cells after 72 hrs by MTT assay
[PMID: 29066046]
T47D IC50
36.6 μM
Compound: 1
Antiproliferative activity against human T47D cells after 72 hrs by MTT assay
Antiproliferative activity against human T47D cells after 72 hrs by MTT assay
[PMID: 29066046]
In Vivo

Hecogenin (3.1-90 mg/kg; oral administration; for 15 hours; male Swiss mice) acutely administered, before ethanol, exhibits a potent gastroprotective effect. The Hecogenin pretreatment normalizes GSH levels and significantly reduces lipid peroxidation and nitrite levels in the stomach, as evaluated by the ethanol-induced gastric lesion model. Hecogenin also decreases MPO release and significantly protects the gastric mucosa[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss mice (20-30 g) with ethanol[1]
Dosage: 3.1 mg/kg, 7.5 mg/kg, 15 mg/kg, 30 mg/kg, 60 mg/kg and 90 mg/kg
Administration: Oral administration; for 15 hours
Result: Normalized GSH levels and significantly reduced lipid peroxidation and nitrite levels in the stomach, as evaluated by the ethanol-induced gastric lesion model. Decreased MPO release and significantly protected the gastric mucosa.
Molecular Weight

430.62

Formula

C27H42O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[H][C@]1(O[C@@]2(OC[C@H](C)CC2)[C@@H](C)[C@@]1([C@]34C)[H])C[C@@]3([H])[C@]5([H])CC[C@@]6([H])C[C@@H](O)CC[C@]6(C)[C@@]5([H])CC4=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMF : 16.67 mg/mL (38.71 mM; ultrasonic and warming and heat to 60°C)

H2O : < 0.1 mg/mL (insoluble)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3222 mL 11.6112 mL 23.2223 mL
5 mM 0.4644 mL 2.3222 mL 4.6445 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.85%

SDS (392 KB)

COA (252 KB) RP-HPLC (217 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF 1 mM 2.3222 mL 11.6112 mL 23.2223 mL 58.0558 mL
5 mM 0.4644 mL 2.3222 mL 4.6445 mL 11.6112 mL
10 mM 0.2322 mL 1.1611 mL 2.3222 mL 5.8056 mL
15 mM 0.1548 mL 0.7741 mL 1.5482 mL 3.8704 mL
20 mM 0.1161 mL 0.5806 mL 1.1611 mL 2.9028 mL
25 mM 0.0929 mL 0.4644 mL 0.9289 mL 2.3222 mL
30 mM 0.0774 mL 0.3870 mL 0.7741 mL 1.9352 mL
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Hecogenin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hecogenin467-55-0FungalInhibitorinhibitorinhibit

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