Bismuth Subsalicylate (Synonyms: Bismuth oxysalicylate; Bismuth(III) salicylate basic)

Cat. No.: HY-B0550 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

Bismuth Subsalicylate is a potent and orally active antacid and anti-diarrheal agent. Bismuth Subsalicylate reduces inflammation/irritation of stomach and intestinal lining through inhibition of prostaglandin synthesis in vivo. Bismuth Subsalicylate is widely used for the research of diarrheal disorders, including indigestion,?diarrhoea, nausea, et al.

For research use only. We do not sell to patients.

Bismuth Subsalicylate Chemical Structure

CAS No. : 14882-18-9

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500 mg	In-stock	Estimated Time of Arrival: December 31
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Other Forms of Bismuth Subsalicylate:

Bismuth Subsalicylate (Standard) Get quote

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Biological Activity
Purity & Documentation
References
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Description

Bismuth Subsalicylate is a potent and orally active antacid and anti-diarrheal agent. Bismuth Subsalicylate reduces inflammation/irritation of stomach and intestinal lining through inhibition of prostaglandin synthesis in vivo^[1]. Bismuth Subsalicylate is widely used for the research of diarrheal disorders, including indigestion,?diarrhoea, nausea, et al^[1]^[2].

In Vivo

In the gastrointestinal tract, Bismuth Subsalicylate can be converted to salicylic acid and insoluble bismuth salts. Salicylic acid reduces inflammation/irritation of stomach and intestinal lining through inhibition of prostaglandin G/H synthase 1/2^[1].
Bismuth Subsalicylate (oral gavage; 100 mg/kg-350 mg/kg) significantly decreases castor oil-induced movement of a charcoal test meal along the small intestine of the mouse and rat and also decreases both the fecal output (dry or wet weight) and the frequency of diarrhea in mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

362.09

Formula

C₇H₅BiO₄

CAS No.

14882-18-9

Appearance

Solid

Color

White to off-white

SMILES

O=C1O[Bi](O)OC2=CC=CC=C12

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

H₂O : 10 mg/mL (27.62 mM; ultrasonic and adjust pH to 2 with CH3COOH)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7617 mL	13.8087 mL	27.6174 mL
5 mM	0.5523 mL	2.7617 mL	5.5235 mL
10 mM	0.2762 mL	1.3809 mL	2.7617 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (251 KB)

Handling Instructions (2659 KB)

References

[1]. Bismuth subsalicylate. Drug.bank

[2]. Alejandra Orona-Ortiz, et al. Mucoadhesive effect of Curcuma longa extract and curcumin decreases the ranitidine effect, but not bismuth subsalicylate on ethanol-induced ulcer model. Sci Rep. 2019 Nov 12;9(1):16622. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.7617 mL	13.8087 mL	27.6174 mL	69.0436 mL
	5 mM	0.5523 mL	2.7617 mL	5.5235 mL	13.8087 mL
	10 mM	0.2762 mL	1.3809 mL	2.7617 mL	6.9044 mL
	15 mM	0.1841 mL	0.9206 mL	1.8412 mL	4.6029 mL
	20 mM	0.1381 mL	0.6904 mL	1.3809 mL	3.4522 mL
	25 mM	0.1105 mL	0.5523 mL	1.1047 mL	2.7617 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Bismuth Subsalicylate Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bismuth Subsalicylate14882-18-9Bismuth oxysalicylate Bismuth(III) salicylate basicPGE synthaseProstaglandin E synthaseheartburnacid reflux,?indigestion,?diarrhoeasickantacidnausea,?salicylateinflammationInhibitorinhibitorinhibit

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