2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Amine N-methyltransferase

Amine N-methyltransferase

Amine N-methyltransferase

Amine N-methyltransferase is an enzyme that catalyzes the N-methylation reaction of amine compounds. According to the substrates of Amine N-methyltransferase, it can be classified into PNMT, NNMT, GNMT and HNMT. Amine N-methyltransferase is involved in physiological processes such as neurotransmitter metabolism and bioactive natural products synthesis. Changes in the activity of amine Amine N-methyltransferase are related to the occurrence and development of diseases such as neurological diseases and cancers[1].

Amine N-methyltransferase Isoform Specific Products:

Amine N-methyltransferase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-112584
    JBSNF-000088
    		Inhibitor 99.94%
    JBSNF-000088 (6-Methoxynicotinamide), a analog of nicotinamide (NA), is a potent and orally active Nicotinamide N-methyltransferase (NNMT) inhibitor with IC50s of 1.8 µM, 2.8 µM, and 5.0 µM for human NNMT, monkey NNMT and mouse NNMT, respectively. JBSNF-000088 inhibits NNMT activity, reduces MNA levels and drives insulin sensitization, glucose modulation and body weight reduction in animal models of metabolic disease.
    JBSNF-000088
  • HY-131042
    NNMTi
    		Inhibitor 99.80%
    NNMTi is a potent nicotinamide N-methyltransferase (NNMT) inhibitor (IC50=1.2 μM) and selectively binds to the NNMT substrate-binding site residues. NNMTi  promotes myoblast differentiation in vitro and enhances fusion and regenerative capacity of muscle stem cells (muSCs) in aged mice.
    NNMTi
  • HY-148904
    Allylic-SAM
    Allylic-SAM is an S-adenosyl methionine (SAM) analog for the enrichment and detection of methyltransferase target sites in RNA.
    Allylic-SAM
  • HY-151500B
    JBSNF-000028 hydrochloride
    		Inhibitor
    JBSNF-000028 hydrochloride is an orally active nicotinamide N-methyltransferase (NNMT) inhibitor with IC50s of 0.033 μM, 0.19 μM and 0.21 μM against human NNMT (hNNMT), monkey NNMT (mkNNMT), and mouse NNMT (mNNMT), respectively. JBSNF-000028 hydrochloride can be used for the research of metabolic disorders.
    JBSNF-000028 hydrochloride
  • HY-151500A
    JBSNF-000028 TFA
    		Inhibitor 99.47%
    JBSNF-000028 TFA is an orally active nicotinamide N-methyltransferase (NNMT) inhibitor with IC50s of 0.033 μM, 0.19 μM and 0.21 μM against human NNMT (hNNMT), monkey NNMT (mkNNMT), and mouse NNMT (mNNMT), respectively. JBSNF-000028 TFA can be used for the research of metabolic disorders.
    JBSNF-000028 TFA
  • HY-W093017
    4-Chloropyridine
    		Inhibitor
    4-Chloropyridine is an inhibitor of nicotinamide N-methyltransferase (NNMT). It can act as a substrate for NNMT and, during its catalytic reaction, enhances the electrophilicity of the C4 position by methylating the nitrogen atom of the pyridine ring. This promotes an aromatic nucleophilic substitution reaction with the non-catalytic cysteine (C159) in NNMT, ultimately leading to the suicide inhibition of NNMT's activity. 4-Chloropyridine holds potential for the development of NNMT activity-based probes .
    4-Chloropyridine
  • HY-W1006754
    NNMT-IN-7
    		Inhibitor
    NNMT-IN-7 (Compound 4e) is a NNMT inhibitor (IC50 = 505.7 µM). NNMT-IN-7 can be used in studies of metabolic and chronic diseases.
    NNMT-IN-7
  • HY-151500
    JBSNF-000028 free base
    		Inhibitor 99.20%
    JBSNF-000028 is an orally active nicotinamide N-methyltransferase (NNMT) inhibitor with IC50s of 0.033 μM, 0.19 μM and 0.21 μM against human NNMT (hNNMT), monkey NNMT (mkNNMT), and mouse NNMT (mNNMT), respectively. JBSNF-000028 can be used for the research of metabolic disorders.
    JBSNF-000028 free base
  • HY-163174
    II399
    		Inhibitor
    II399 is a potent, selective NNMT bisubstrate inhibitor containing an unconventional SAM mimic, with a Ki of 5.9 nM. II399 exhibits an explicit pattern of competitive inhibition for NAM. II399 occupies both the substrate and cofactor binding pockets. II399 has the potential for the research of cancers, metabolic, cardiovascular, and neurodegenerative diseases.
    II399
  • HY-151193
    NNMT-IN-3
    		Inhibitor
    NNMT-IN-3 (compound 14) is a potent and selective nicotinamide N-methyltransferase NNMT inhibitor with IC50 values of 1.1 nM and 0.4 μM in cell-free and cell-based assays, respectively. NNMT-IN-3 can be used to research obesity, type 2 diabetes, alcohol-related liver disease, cancer, sarcopenia and so on.
    NNMT-IN-3
Amine N-methyltransferase Isoform Comparison

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