IPK Superfamily

Inositiol Polyphosphate Kinase (IPK) Superfamily

Inositiol Polyphosphate Kinase (IPK) Superfamily is a family of enzymes that have a similar 3-dimensional structure. All members of the family catalyze the transfer of phosphate groups from ATP to various inositol phosphates. Members of the family include inositol-polyphosphate multikinases (IPMK), inositol-hexakisphosphate kinases, inositol-trisphosphate 3-kinases (PI3K) and inositol-pentakisphosphate 2-kinase (IP5P2K). Members of the IPK superfamily play important roles in various signaling pathways by altering the phosphorylation state of the second messenger inositol phosphates. Some members of the IPK superfamily are involved in regulating inositol phosphate metabolism related to vesicle transport, ensuring the accurate progress of intracellular substance transport. Abnormal functions of IPK superfamily members are closely related to the occurrence and development of various diseases, such as cancer, neurological diseases, and metabolic diseases^[1]^[2]^[3].

References:

[1]. Xiong T, et al. Origin, evolution, and diversification of inositol 1,4,5-trisphosphate 3-kinases in plants and animals. BMC Genomics. 2024 Apr 8;25(1):350.

[2]. Malabanan MM, et al. Inositol polyphosphate multikinase (IPMK) in transcriptional regulation and nuclear inositide metabolism. Biochem Soc Trans. 2016 Feb;44(1):279-85. [Content Brief]

[3]. Kim E, et al. IPMK: A versatile regulator of nuclear signaling events. Adv Biol Regul. 2016 May;61:25-32. [Content Brief]

IPK Superfamily Related Products (5):

By Effects:	Inhibitors (3) Agonists (2)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-110079

TNP	Inhibitor	99.29%
TNP is a cell-permeable inhibitor of IP6K1 and IP3K, with IC₅₀ values of 0.55 µM and 10.2 µM for IP3K, respectively. TNP binds to the ATP-binding sites of both enzymes.

HY-P4195A

[K15,R16,L27]VIP(1-7)/GRF(8-27) acetate	Agonist
[K15,R16,L27]VIP(1-7)/GRF(8-27) (acetate) is the acetate of [K15,R16,L27]VIP(1-7)/GRF(8-27) (HY-P4195). [K15,R16,L27]VIP(1-7)/GRF(8-27) (acetate), a VIP₁ selective agonist, exhibits IC₅₀ values of binding of 2 nM, 1 nM, 30,000 nM for the human VIP₁, rat VIP₁, rat VIP₂ receptors, respectively. VIP: VASOACTIVE Intestinal Polypeptide

HY-P4195

[K15,R16,L27]VIP(1-7)/GRF(8-27)	Agonist
[K15,R16,L27]VIP(1-7)/GRF(8-27), a VIP₁ selective agonist, exhibits IC₅₀ values of binding of 2 nM, 1 nM, 30,000 nM for the human VIP₁, rat VIP₁, rat VIP₂ receptors, respectively. VIP: VASOACTIVE Intestinal Polypeptide

HY-122706A

IP6K2-IN-2	Inhibitor
IP6K2-IN-2 (Compound 6) is an IP6K2 inhibitor, with IC₅₀ values of 0.58 μM (IP6K2), 0.86 μM (IP6K1) and 3.08 μM (IP6K3). IP6K2-IN-2 can be used in research of obesity.

HY-162016

IP6K-IN-1	Inhibitor
IP6K-IN-1 (compound 24) is a potent and selective inhibitor of IP6K with an IC₅₀ of 0.896 μM. IP6K-IN-1 can used in study metabolic disease.

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