Indoleamine 2,3-Dioxygenase (IDO)

Indoleamine 2,3-Dioxygenase (IDO) Related Products (47):

By Effects:	Inhibitors (43) Antagonist (1) Activator (1)

Cat. No.	Product Name	Effect	Purity

HY-145280A

IDO1/2-IN-1 hydrochloride	Inhibitor
IDO1/2-IN-1 hydrochloride (compound 4t) is the first potent IDO1/IDO2 dual inhibitor with IC₅₀s of 28 nM and 144 nM for IDO1 and IDO2, respectively. IDO1/2-IN-1 hydrochloride exhibits antitumor activies. Orally active.

HY-151978

ZC0109	Inhibitor	99.32%
ZC0109 is a dual inhibitor of IDO1 and thioredoxin reductase 1 (TrxR1) with IC₅₀s of 50 nM and 3.0 μM, respectively. ZC0109 induces ROS accumulation and cell cycle arrest at G1/S phase, thus leads to cancer cells apoptosis.

HY-148173

NUCC-0223619	Inhibitor
NUCC-0223619 is an IDO1 inhibitor, induce degradation of IDO protein. NUCC-0223619 can be used to synthesis PROTAC.

HY-146674

IDO1/TDO-IN-3	Inhibitor
IDO1/TDO-IN-3 is a potent inhibitor of IDO1/TDO. IDO1/TDO-IN-3 exhibits significant activities against IDO1 (IC₅₀: 0.005 μM) and TDO (IC₅₀: 0.004 μM). IDO1/TDO-IN-3 shows considerable in vivo anti-tumor activity and no obvious toxicity is observed.

HY-139883

IDO-IN-15	Inhibitor
IDO-IN-15 is an IDO1 inhibitor (IC₅₀ < 0.51 nM).

HY-112164A

IACS-8968 R-enantiomer	Inhibitor	98.48%
IACS-8968 (R-enantiomer) is the R-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor, with pIC₅₀s of 6.43 for IDO and <5 for TDO, respectively.

HY-160025

IDO antagonist-1	Antagonist
IDO antagonist-1 (compound 163) is an antagonist of IDO . IDO antagonist-1 inhibits pancreatic adenocarcinoma cells growth in C57BL/6 mice.

HY-156400

IDO1-IN-23	Inhibitor
IDO1-IN-23 (compound 41) is a potent human IDO1 inhibitor with an IC₅₀ value of 13 μM.

HY-129749

IDO-IN-13	Inhibitor
IDO-IN-13 is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an EC₅₀ of 17 nM, extracted from patent WO2019040102A1, example 43.

HY-146673

IDO1/TDO-IN-2	Inhibitor
IDO1/TDO-IN-2 (Compound 1) is a potent inhibitor of IDO1/TDO with IC₅₀s of 0.1 and 0.07 μM. IDO1/TDO-IN-2 has the potential for the research of cancer diseases.

HY-142933

IDO-IN-16	Inhibitor
IDO-IN-16 (compound 5) is an IDO inhibitor, with an IC₅₀ of 36 nM.

HY-P4149

Imsamotide	Inhibitor
Imsamotide (IDO194-214) is a Indoleamine 2,3-Dioxygenase (IDO) peptide with sequences of DTLLKALLEIASCLEKALQVF, the IDO194-214. Imsamotide is also an immunological agent for active immunization, as well as an antineoplastic agent.

HY-146261

HI5	Inhibitor
HI5 is a potent tublin and IDO inhibitor, with an IC₅₀ value of 70 nM in HeLa cells. HI5 inhibit IDO expression and decrease kynurenine production, leading to stimulating T cells activation and proliferation. HI5 can inhibit tubulin polymerization and cell migration, cause G2/M phase arrest, and induce apoptosis via the mitochondrial dependent apoptosis pathway and cause reactive oxidative stress generation in HeLa cells. HI5 can be used for researching anticancer.

HY-146215

IDO1-IN-20
Hy-146215 is an enzyme that catalyzes the oxidative metabolism of tryptophan. It can immunosuppress tumors in the tumor microenvironment.

HY-163520

IDO1-IN-24	Inhibitor
IDO1-IN-24 (compound 2c) inhibits IDO1 production in cell-based assay with an IC₅₀ value of 17 μM.

HY-N0110R

Palmatine chloride (Standard)	Inhibitor
Palmatine (chloride) (Standard) is the analytical standard of Palmatine (chloride). This product is intended for research and analytical applications. Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities.

HY-N11451

Lacto-N-fucopentaose III	Activator
Lacto-N-fucopentaose III (LNFP-III) is an immune modulator. Lacto-N-fucopentaose III reduces the severity of experimental autoimmune encephalomyelitis (EAE) and CNS inflammation.

HY-145355

IDO1-IN-12	Inhibitor
IDO1-IN-12 is a potent and orally available IDO1 inhibitor.

HY-149982

IDO1-IN-22	Inhibitor
IDO1-IN-22 (Compound 3) is a IDO1 inhibitor (biochemical hIDO1 IC₅₀: 67.4 nM, HeLa hIDO1 IC₅₀: 17.6 nM). IDO1-IN-22 has excellent antitumor efficacy in LLC xenograft model, as well as desirable pharmacokinetic (PK) profile.

HY-151425

TDO-IN-1	Inhibitor	99.07%
TDO-IN-1 is an orally active and selective inhibitor of tryptophan 2,3-dioxygenase (TDO), shows excellent selectivity over indoleamine-2,3-dioxygenase (IDO), with an IC₅₀ value of 0.62 μM (IDO). TDO-IN-1 reverse the local immune tolerance of tumor tissue to inhibit tumor growth in vivo.

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