2. Metabolic Enzyme/Protease
  3. Indoleamine 2,3-Dioxygenase (IDO)
  4. IACS-8968 R-enantiomer

IACS-8968 R-enantiomer  (Synonyms: IDO/TDO Inhibitor (R-enantiomer))

Cat. No.: HY-112164A Purity: 98.48% ee.: 99.78%
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IACS-8968 (R-enantiomer) is the R-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor, with pIC50s of 6.43 for IDO and <5 for TDO, respectively.

For research use only. We do not sell to patients.

IACS-8968 R-enantiomer Chemical Structure

IACS-8968 R-enantiomer Chemical Structure

CAS No. : 2239305-67-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 743 In-stock
Solution
10 mM * 1 mL in DMSO USD 743 In-stock
Solid
1 mg USD 220 In-stock
5 mg USD 675 In-stock
10 mg USD 1100 In-stock
25 mg USD 2200 In-stock
50 mg USD 3400 In-stock
100 mg   Get quote  
200 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Other Forms of IACS-8968 R-enantiomer:

IACS-8968 R-enantiomer Related Antibodies

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View All Indoleamine 2,3-Dioxygenase (IDO) Isoform Specific Products:

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IDO1 IDO2 IDO

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Description

IACS-8968 (R-enantiomer) is the R-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor, with pIC50s of 6.43 for IDO and <5 for TDO, respectively.

IC50 & Target

IDO, TDO[1].
Molecular Weight

381.35

Formula

C17H18F3N5O2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N1)N[C@]2(C(C)(C)CN(C3=CC(C(F)(F)F)=CC4=CN=CN34)CC2)C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (131.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6223 mL 13.1113 mL 26.2226 mL
5 mM 0.5245 mL 2.6223 mL 5.2445 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6223 mL 13.1113 mL 26.2226 mL 65.5566 mL
5 mM 0.5245 mL 2.6223 mL 5.2445 mL 13.1113 mL
10 mM 0.2622 mL 1.3111 mL 2.6223 mL 6.5557 mL
15 mM 0.1748 mL 0.8741 mL 1.7482 mL 4.3704 mL
20 mM 0.1311 mL 0.6556 mL 1.3111 mL 3.2778 mL
25 mM 0.1049 mL 0.5245 mL 1.0489 mL 2.6223 mL
30 mM 0.0874 mL 0.4370 mL 0.8741 mL 2.1852 mL
40 mM 0.0656 mL 0.3278 mL 0.6556 mL 1.6389 mL
50 mM 0.0524 mL 0.2622 mL 0.5245 mL 1.3111 mL
60 mM 0.0437 mL 0.2185 mL 0.4370 mL 1.0926 mL
80 mM 0.0328 mL 0.1639 mL 0.3278 mL 0.8195 mL
100 mM 0.0262 mL 0.1311 mL 0.2622 mL 0.6556 mL
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IACS-8968 R-enantiomer Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IACS-8968 R-enantiomer2239305-67-8IDO/TDO Inhibitor (R-enantiomer)Indoleamine 2,3-Dioxygenase (IDO)Inhibitorinhibitorinhibit

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