Ligands for E3 Ligase Degrader

Ligands for E3 Ligase Degrader (1):

Cat. No.	Product Name	CAS No.	Purity	Chemical Structure

Ru-Poma
Ru-Poma is a Ru(II)-based photosensitizer, which attenuates Cisplatin (HY-17394)-resistant tumor through photodynamic therapy (PDT). Ru-Poma photodegrades CRBN through a Pomalidomide (HY-10984) moiety. Ru-Poma induces ferroptosis, through an increase in lipid peroxide, downregulation of GPX4 and GAPDH expression. Ru-Poma exhibits cytotoxicity in A549, with IC₅₀ of 18.46 μM and 0.37 μM in dark and upon irradiation, respectively.

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