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  4. Disodium 5'-inosinate

Disodium 5'-inosinate  (Synonyms: IMP disodium salt; Disodium inosinate)

Cat. No.: HY-D0887 Purity: 99.74%
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Disodium 5'-inosinate (IMP disodium salt) is a nucleotide-based umami agent. Disodium 5'-inosinate can bind to umami receptors and stimulate taste nerves, allowing the brain to perceive umami. In addition, Disodium 5'-inosinate produces a transient behavioral excitement in mice.

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Disodium 5'-inosinate Chemical Structure

Disodium 5'-inosinate Chemical Structure

CAS No. : 4691-65-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 44 In-stock
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10 mM * 1 mL in Water USD 44 In-stock
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1 g USD 40 In-stock
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Based on 1 publication(s) in Google Scholar

Disodium 5'-inosinate Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Disodium 5'-inosinate

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Disodium 5'-inosinate (IMP disodium salt) is a nucleotide-based umami agent. Disodium 5'-inosinate can bind to umami receptors and stimulate taste nerves, allowing the brain to perceive umami. In addition, Disodium 5'-inosinate produces a transient behavioral excitement in mice[1][2].

In Vivo

Disodium 5'-inosinate (0.001 M 2 mL; Oral catheterization; Single dose) responds to oral stimulation in rat solitary-tract nucleus neurons and is involved in encoding umami taste[1].
Disodium 5'-inosinate (500 mg/kg; Intravenous injection; Single dose) produces a transient behavioral excitement in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice[2]
Dosage: 500 mg/kg
Administration: Intravenous injection (i.v.); Single dose
Result: Produced a behavioral excitement, showing an increased movement, jumping and squeaking in response to tactile stimuli and enhanced preening and increased reflex response, but the animals became sedate after 60 min.
Molecular Weight

392.17

Formula

C10H11N4Na2O8P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=P(OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C(N=CN=C32)O)O1)O)O)(O[Na])O[Na]
Structure Classification
Initial Source

Corynebacterium stationis?KCCM 80235
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (637.48 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5499 mL 12.7496 mL 25.4991 mL
5 mM 0.5100 mL 2.5499 mL 5.0998 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (127.50 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.74%

SDS (393 KB)

COA (255 KB) LCMS (120 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.5499 mL 12.7496 mL 25.4991 mL 63.7479 mL
5 mM 0.5100 mL 2.5499 mL 5.0998 mL 12.7496 mL
10 mM 0.2550 mL 1.2750 mL 2.5499 mL 6.3748 mL
15 mM 0.1700 mL 0.8500 mL 1.6999 mL 4.2499 mL
20 mM 0.1275 mL 0.6375 mL 1.2750 mL 3.1874 mL
25 mM 0.1020 mL 0.5100 mL 1.0200 mL 2.5499 mL
30 mM 0.0850 mL 0.4250 mL 0.8500 mL 2.1249 mL
40 mM 0.0637 mL 0.3187 mL 0.6375 mL 1.5937 mL
50 mM 0.0510 mL 0.2550 mL 0.5100 mL 1.2750 mL
60 mM 0.0425 mL 0.2125 mL 0.4250 mL 1.0625 mL
80 mM 0.0319 mL 0.1594 mL 0.3187 mL 0.7968 mL
100 mM 0.0255 mL 0.1275 mL 0.2550 mL 0.6375 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Disodium 5'-inosinate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Disodium 5'-inosinate4691-65-0IMP disodium Disodium inosinateBiochemical Assay ReagentsFood AdditiveUmami agentInhibitorinhibitorinhibit

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