ADH6 - alcohol dehydrogenase 6 (class V) Gene

Homo sapiens

Also known as ADH-5

Gene ID: 130 | Gene type: protein coding

About ADH6

Cytogenetic location: 4q23 Genomic coordinates (GRCh38): 4:99,202,639-99,219,246 (from NCBI)

This gene has 8 transcripts (splice variants), 375 orthologues and 17 paralogues. Biased expression in liver (RPKM 139.0), duodenum (RPKM 20.7) and 2 other tissues.

Summary

This gene encodes class V alcohol dehydrogenase, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, Other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This gene is expressed in the stomach as well as in the liver, and it contains a glucocorticoid response element upstream of its 5' UTR, which is a steroid hormone receptor binding site. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ADH6 Products(2)

mRNA	Protein	Name
NM_000672.4	NP_000663.1	alcohol dehydrogenase 6 isoform 2
NM_001102470.2	NP_001095940.1	alcohol dehydrogenase 6 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables alcohol dehydrogenase (NAD+) activity	IDA IDA: Inferred from direct assay	1755855	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADH6 Protein Structure

ADH_N

ADH_zinc_N

0
100
200
300
368 a.a.

Protein Preferred Names

Protein Names

alcohol dehydrogenase 6

aldehyde reductase

Related Diseases

Diseases

Alias

Proliferative Type Fibrocystic Change Of Breast

Fibrocystic Change, Proliferative Type With Atypia	Fibrocystic Disease, Proliferative Type With Atypia
Proliferating Lesion Of Breast Without Atypia	Proliferating Lesion Of The Breast Without Atypia
Proliferative Fibrocystic Change	Breast Fibrocystic Change, Proliferative Type

Amed Syndrome, Digenic

Amed Syndrome	AMEDS
Bone Marrow Failure Syndrome 7, Digenic	Bmfs7
Aplastic Anemia-Intellectual Disability-Dwarfism Syndrome

Breast Intraductal Proliferative Lesion

Intraductal Proliferative Lesion

Intraductal Proliferative Lesion Of The Breast

Alcohol Dependence

Alcoholism	Alcohol Dependence, Susceptibility To
Alcohol Dependence, Protection Against	Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against
Alcoholism, Susceptibility To	Alcoholic Intoxication, Chronic
Pharyngeal Neoplasms	Chronic Alcoholism
Dipsomania	Alcohol Addiction
Ethanol Dependence	Chronic Ethanolism
Chronic Alcoholic Disease Nos	Alcoholic Disease Nos
Alcoholic

Alzheimer Disease 3

AD3	Alzheimer Disease, Type 3
Alzheimer Disease, Type 3, With Spastic Paraparesis And Apraxia	Alzheimer Disease, Type 3, With Spastic Paraparesis And Unusual Plaques
Alzheimer'S Disease 3	Alzheimer Disease, Familial, 3, With Spastic Paraparesis And Apraxia
Alzheimer Disease 3, Early-Onset	Alzheimer Disease, Familial, 3
Alzheimer Disease, Protection Against, Due To Apoe3-Christchurch	Alzheimer Disease 3, Early Onset
Alzheimer Disease Familial 3	Early-Onset Familial Alzheimer Disease 3
Familial Alzheimer Disease 3	Familial Alzheimer Disease 3 With Spastic Paraparesis And Apraxia
Familial Alzheimer Disease 3 With Spastic Paraparesis And Unusual Plaques	Alzheimer Disease, Familial, 3, With Spastic Paraparesis And Unusual Plaques
Alzheimer Disease, Familial, Type 3

Focal Dermal Hypoplasia

Goltz Syndrome	Goltz-Gorlin Syndrome
FDH	FODH
Dhof	Goltz Gorlin Syndrome
Hypoplasia, Dermal, Focal

Substance Dependence

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145785A	ADH-6 TFA		99.91%	Unkown
HY-145785	ADH-6		/	Unkown
HY-RS00373	ADH6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ADH6	RGD	RGD:1306313
Mus musculus	ADH6	MGD	MGI:2446626

Name
Email *

	Sorry, but the email address you supplied was invalid.