ANKRD6 - ankyrin repeat domain 6 Gene

Homo sapiens

Gene ID: 22881 | Gene type: protein coding

About ANKRD6

Cytogenetic location: 6q15 Genomic coordinates (GRCh38): 6:89,433,152-89,633,834 (from NCBI)

This gene has 22 transcripts (splice variants), 220 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 8.1), ovary (RPKM 5.5) and 25 other tissues.

Summary

Predicted to be involved in negative regulation of canonical Wnt signaling pathway and positive regulation of JNK cascade. Predicted to act upstream of or within positive regulation of Wnt signaling pathway, planar cell polarity pathway. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022]

ANKRD6 Products(5)

mRNA	Protein	Name
NM_001242809.2	NP_001229738.1	ankyrin repeat domain-containing protein 6 isoform a
NM_001242811.1	NP_001229740.1	ankyrin repeat domain-containing protein 6 isoform a
NM_001242813.1	NP_001229742.1	ankyrin repeat domain-containing protein 6 isoform c
NM_001242814.1	NP_001229743.1	ankyrin repeat domain-containing protein 6 isoform d
NM_014942.4	NP_055757.3	ankyrin repeat domain-containing protein 6 isoform b

ANKRD6 Protein Structure

Ank_2

Ank

Ank_2

0
200
400
600
727 a.a.

Protein Preferred Names

Protein Names

ankyrin repeat domain-containing protein 6

diego homolog

Related Diseases

Diseases

Alias

Neural Tube Defects

Spina Bifida	Neural Tube Defect
NTD	Neural Tube Defects, Susceptibility To
Spinal Dysraphism	Spina Bifida, Susceptibility To
Rachischisis	Cleft Spine
Open Spine	Hydrocele Spinalis
Neural Tube Defect Nos	Sb - [Spina Bifida]
Spinal Hernia Nos	Spinal Fissure Nos

Ocular Motility Disease

Ocular Motility Disorders	Abnormality Of Eye Movement
Disorder Of Eye Movements	Eye Movement Disorder
Eye Movement Disorders

Strabismus

Strabismus, Susceptibility To	Strabismus, Susceptibility To, 1
Strabismus 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00733	ANKRD6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ANKRD6	VGNC	VGNC:53781
Rattus norvegicus	ANKRD6	RGD	RGD:1583731
Canis familiaris	ANKRD6	VGNC	VGNC:52103
Mus musculus	ANKRD6	MGD	MGI:2154278
Macaca mulatta	ANKRD6	VGNC	VGNC:81023
Felis catus	ANKRD6	VGNC	VGNC:102380

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