GH2 - growth hormone 2 Gene

Homo sapiens

Also known as GHL; GHV; GH-V; GHB2; hGH-V

Gene ID: 2689 | Gene type: protein coding

About GH2

Cytogenetic location: 17q23.3 Genomic coordinates (GRCh38): 17:63,880,215-63,881,944 (from NCBI)

This gene has 5 transcripts (splice variants), 202 orthologues and 5 paralogues. Restricted expression toward placenta (RPKM 103.3).

Summary

The protein encoded by this gene is a member of the somatotropin/Prolactin family of Hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth Hormones, leading to further diversity and potential for specialization. As in the case of its pituitary counterpart, growth hormone 1, the predominant isoform of this particular family member shows similar somatogenic activity, with reduced lactogenic activity. Mutations in this gene lead to placental growth hormone/lactogen deficiency. [provided by RefSeq, Jul 2008]

GH2 Products(4)

mRNA	Protein	Name
NM_002059.5	NP_002050.1	growth hormone variant isoform 1 precursor
NM_022556.4	NP_072050.1	growth hormone variant isoform 4 precursor
NM_022557.4	NP_072051.1	growth hormone variant isoform 2 precursor
NM_022558.4	NP_072052.1	growth hormone variant isoform 3 precursor

GH2 Protein Structure

Hormone_1

0
100
200
217 a.a.

Protein Preferred Names

Protein Names

growth hormone variant

growth hormone B2

Related Diseases

Diseases

Alias

Protein-Deficiency Anemia

Anemia Due To Protein Deficiency	Protein-Deficiency Anaemia
Amino-Acid Deficiency Anaemia	Anaemia Due To Amino-Acid Disorder

Choriocarcinoma

Chorioepithelioma

Diencephalic Astrocytoma

Astrocytoma Of Diencephalon

Adermatoglyphia

ADERM	Immigration Delay Disease
Absence Of Fingerprints	Adg
Congenital Absence Of Fingerprints	Isolated Congenital Adermatoglyphia
Fingerprints, Absence Of	Skin Abnormalities

Gaba Aminotransferase Deficiency

Gamma-Aminobutyric Acid Transaminase Deficiency	Gamma Aminobutyric Acid Transaminase Deficiency
Gaba Transaminase Deficiency	Gamma-Amino Butyric Acid Transaminase Deficiency
4 Alpha Aminobutyrate Transaminase Deficiency	Abat
Gabat	Gamma Aminobutyrate Transaminase Deficiency

Enterocele

Vaginal Enterocele	Hernia
Hernias

Prolapse Of Female Genital Organ

Hyperpituitarism

Isolated Growth Hormone Deficiency, Type Ii

Ighd Ii	Isolated Growth Hormone Deficiency Type Ii
IGHD2	Growth Hormone Deficiency, Isolated, Type Ii
Congenital Ighd Type Ii	Congenital Isolated Gh Deficiency Type Ii
Congenital Isolated Growth Hormone Deficiency Type Ii	Pituitary Dwarfism Due To Isolated Growth Hormone Deficiency Autosomal Dominant
Growth Hormone Deficiency, Isolated, Autosomal Dominant	Pituitary Dwarfism Due To Isolated Growth Hormone Deficiency, Autosomal Dominant
Autosomal Dominant Isolated Growth Hormone Deficiency	Autosomal Dominant Pituitary Dwarfism Due To Isolated Growth Hormone Deficiency
Isolated Growth Hormone Deficiency Type 2	Growth Hormone Deficiency, Isolated Autosomal Dominant
Growth Hormone Deficiency, Isolated, 2	Growth Hormone Deficiency Isolated Autosomal Dominant

Pituitary Gland Disease

Pituitary Diseases	Pituitary Dysfunction
Pituitary Disease	Pituitary Deficiency
Pituitary Disorders

Deficiency Anemia

Anemia	Deficiency Anemias
Anaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05409	GH2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GH2	MGD	MGI:95707

Name
Email *

	Sorry, but the email address you supplied was invalid.