RBMS3 - RNA binding motif single stranded interacting protein 3 Gene

Homo sapiens

Gene ID: 27303 | Gene type: protein coding

About RBMS3

Cytogenetic location: 3p24.1 Genomic coordinates (GRCh38): 3:29,281,071-30,010,395 (from NCBI)

This gene has 20 transcripts (splice variants), 264 orthologues and 24 paralogues. Broad expression in thyroid (RPKM 7.8), fat (RPKM 6.1) and 23 other tissues.

Summary

This gene encodes an RNA-binding protein that belongs to the c-Myc gene single-strand binding protein family. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. These proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and Apoptosis. The encoded protein was isolated by virtue of its binding to an upstream element of the alpha2(I) collagen promoter. The observation that this protein localizes mostly in the cytoplasm suggests that it may be involved in a cytoplasmic function such as controlling RNA metabolism, rather than transcription. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

RBMS3 Products(6)

mRNA	Protein	Name
NM_001003792.3	NP_001003792.1	RNA-binding motif, single-stranded-interacting protein 3 isoform 3
NM_001003793.3	NP_001003793.1	RNA-binding motif, single-stranded-interacting protein 3 isoform 1
NM_001177711.2	NP_001171182.1	RNA-binding motif, single-stranded-interacting protein 3 isoform 5
NM_001177712.2	NP_001171183.1	RNA-binding motif, single-stranded-interacting protein 3 isoform 4
NM_001330696.1	NP_001317625.1	RNA-binding motif, single-stranded-interacting protein 3 isoform 6
NM_014483.4	NP_055298.2	RNA-binding motif, single-stranded-interacting protein 3 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables mRNA 3'-UTR AU-rich region binding	IDA IDA: Inferred from direct assay	10675610	GOA
enables poly(A) binding	IDA IDA: Inferred from direct assay	10675610	GOA
enables poly(U) RNA binding	IDA IDA: Inferred from direct assay	10675610	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in defense response to tumor cell	IMP IMP: Inferred from mutant phenotype	28409548	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	28409548	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	28409548	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	28409548	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10675610	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBMS3 Protein Structure

RRM_1

0
100
200
300
400
437 a.a.

Protein Preferred Names

Protein Names

RNA-binding motif, single-stranded-interacting protein 3

RNA binding motif, single stranded interacting protein

Related Diseases

Diseases

Alias

Osteonecrosis Of The Jaw

Heimler Syndrome 2

HMLR2	Peroxisome Biogenesis Disorder 4c
Pbd4c	Peroxisomal Biogenesis Disorder 4c
Heimler Syndrome, Type 2

Intellectual Disability-Severe Speech Delay-Mild Dysmorphism Syndrome

Foxp1 Syndrome	Mental Retardation With Language Impairment And With Or Without Autistic Features
Foxp1 Related Global Developmental Delay, Intellectual Disability And Speech Defects	Intellectual Disability With Language Impairment And With Or Without Autistic Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11747	RBM3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11762	RBMS3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RBMS3	VGNC	VGNC:33811
Mus musculus	RBMS3	MGD	MGI:2444477
Macaca mulatta	RBMS3	VGNC	VGNC:76474
Rattus norvegicus	RBMS3	RGD	RGD:1588240
Felis catus	RBMS3	VGNC	VGNC:64537
Canis familiaris	RBMS3	VGNC	VGNC:45429

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