ENPP5 - ectonucleotide pyrophosphatase/phosphodiesterase family member 5 Gene

Homo sapiens

Also known as NPP5; NPP-5

Gene ID: 59084 | Gene type: protein coding

About ENPP5

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:46,159,185-46,170,980 (from NCBI)

This gene has 3 transcripts (splice variants), 198 orthologues and 6 paralogues. Biased expression in thyroid (RPKM 24.6), testis (RPKM 20.9) and 13 other tissues.

Summary

This gene encodes a type-I Transmembrane Glycoprotein. Studies in rat suggest the encoded protein may play a role in neuronal cell communications. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2014]

ENPP5 Products(3)

mRNA	Protein	Name
NM_001290072.2	NP_001277001.1	ectonucleotide pyrophosphatase/phosphodiesterase family member 5 isoform 1 precursor
NM_001290073.2	NP_001277002.1	ectonucleotide pyrophosphatase/phosphodiesterase family member 5 isoform 2
NM_021572.6	NP_067547.1	ectonucleotide pyrophosphatase/phosphodiesterase family member 5 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables NAD+ diphosphatase activity	IDA IDA: Inferred from direct assay	28898552	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	28898552	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ENPP5 Protein Structure

Phosphodiest

0
100
200
300
400
477 a.a.

Protein Preferred Names

Protein Names

ectonucleotide pyrophosphatase/phosphodiesterase family member 5

E-NPP 5

Recombinant ENPP5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75734	ENPP-5 Protein, Human (HEK293, His)	Q9UJA9 (P25-G429)	≥95%

Related Diseases

Diseases

Alias

Ceroid Lipofuscinosis, Neuronal, 6a

Neuronal Ceroid Lipofuscinosis 6	CLN6
Vlincl	Cln6 Disease
Ceroid Lipofuscinosis, Neuronal, 6	Late-Infantile Neuronal Ceroid Lipofuscinosis
CLN6A	Neuronal Ceroid Lipofuscinosis, Late Infantile, Variant
Neuronal Ceroid Lipofuscinosis 6a	Neuronal Ceroid Lipofuscinosis 6 Variable Age Of Onset
Cln6 Disease, Adult Kufs Type A	Cln6 Disease, Late Infantile
Neuronal Ceroid Lipofuscinosis, Gypsy/Indian Early Juvenile Variant	Ceroid Lipofuscinosis Neuronal 6
Cln6-Related Neuronal Ceroid Lipofuscinosis	Late Infantile Neuronal Ceroid Lipofuscinosis
Jansky-Bielschowsky Disease	Lincl
Late Infantile Ncl	Neuronal Ceroid Lipofuscinosis 6 With Variable Age At Onset
Variant Late-Onset Infantile Neuronal Ceroid Lipofuscinosis	Ceroid Lipofuscinosis, Neuronal, Late Infantile, Variant
Lipofuscinosis, Ceroid, Neuronal, Type 6	Ceroid Lipofuscinosis, Neuronal, 5

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04391	ENPP5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ENPP5	RGD	RGD:1359199
Macaca mulatta	ENPP5	VGNC	VGNC:104375
Canis familiaris	ENPP5	VGNC	VGNC:58978
Mus musculus	ENPP5	MGD	MGI:1933830
Felis catus	ENPP5	VGNC	VGNC:61875
Bos taurus	ENPP5	VGNC	VGNC:58979

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