2. Gene
  3. ARFGAP2 - ADP ribosylation factor GTPase activating protein 2 Gene

ARFGAP2 - ADP ribosylation factor GTPase activating protein 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as IRZ; ZFP289; ZNF289; NBLA10535

Gene ID: 84364 | Gene type: protein coding

About ARFGAP2

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:47,164,301-47,176,879 (from NCBI)

This gene has 30 transcripts (splice variants), 221 orthologues and 28 paralogues. Ubiquitous expression in skin (RPKM 24.0), brain (RPKM 23.0) and 25 other tissues.

Summary

Predicted to enable GTPase activator activity. Predicted to be involved in COPI coating of Golgi vesicle. Located in Golgi apparatus; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

ARFGAP2 Products(3)

mRNA Protein Name
NM_001242832.2 NP_001229761.1 ADP-ribosylation factor GTPase-activating protein 2 isoform 2
NM_001410995.1 NP_001397924.1 ADP-ribosylation factor GTPase-activating protein 2 isoform 3
NM_032389.6 NP_115765.2 ADP-ribosylation factor GTPase-activating protein 2 isoform 1

ARFGAP2 Protein Structure

ArfGap

ArfGap: Putative GTPase activating protein for Arf (12 - 117)

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  • 521 a.a.
Protein Preferred Names Protein Names

ADP-ribosylation factor GTPase-activating protein 2

GTPase-activating protein ZNF289

Related Diseases

Diseases Alias
Autoimmune Lymphoproliferative Syndrome

ALPS

Canale-Smith Syndrome

Autoimmune Lymphoproliferative Syndrome, Type Ia

Autoimmune Lymphoproliferative Syndrome, Type Ib

Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant

Css

Autoimmune Lymphoproliferative Syndrome, Type 1b

Autoimmune Lymphoproliferative Syndrome, Type 1a

Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant

Fas Deficiency

Autoimmune Lymphoproliferative Syndrome 1a

ALPS1A

Autoimmune Lymphoproliferative Syndrome Type Ia

Autoimmune Lymphoproliferative Syndrome 1b

ALPS1B

Autoimmune Lymphoproliferative Syndrome Type Ib
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00900 ARFGAP2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ARFGAP2 RGD RGD:1306177
Canis familiaris ARFGAP2 VGNC VGNC:38033
Macaca mulatta ARFGAP2 VGNC VGNC:69823
Mus musculus ARFGAP2 MGD MGI:1924288
Bos taurus ARFGAP2 VGNC VGNC:26062
Felis catus ARFGAP2 VGNC VGNC:59867