HMG-CoA Reductase-IN-1

Cat. No.: HY-155668: FAQs
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HMG-CoA Reductase-IN-1 is a HMG-CoA reductase inhibitor. HMG-CoA Reductase-IN-1has high HMGR inhibitory activity and OATP1B1 affinity with pIC₅₀ and pKm values of 8.54 and 1.98, respectively. HMG-CoA Reductase-IN-1 can be used for the research of hypercholesterolemia.

For research use only. We do not sell to patients.

HMG-CoA Reductase-IN-1 Chemical Structure

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Description	HMG-CoA Reductase-IN-1 is a HMG-CoA reductase inhibitor. HMG-CoA Reductase-IN-1has high HMGR inhibitory activity and OATP1B1 affinity with pIC₅₀ and pKm values of 8.54 and 1.98, respectively. HMG-CoA Reductase-IN-1 can be used for the research of hypercholesterolemia^[1].
IC₅₀ & Target	pIC50: 8.54 (HMGR); pKm: 1.98 (OATP1B1)^[1]
Molecular Weight	507.54
Formula	C₂₇H₂₉N₃O₇
SMILES	OC1=CC=C(C=C1)NC(C2=C(/C=C/[C@H](C[C@@H](O)CC(O)=O)O)C(C(C)C)=NC(C3=CC=C(C=C3)O)=N2)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (268 KB) Handling Instructions (2659 KB)
References	[1]. Samizo S, et al. Predictive Modeling of HMG-CoA Reductase Inhibitory Activity and Design of New HMG-CoA Reductase Inhibitors. ACS Omega. 2023 Jul 18;8(30):27247-27255. [Content Brief]