1. Inhibitory Antibodies
  2. Idactamab

Idactamab  (Synonyms: INT-001)

Cat. No.: HY-P99654 Purity: 95.00%
COA

Idactamab (INT-001) is an IgG1-κ antibody with in vivo activity across a spectrum of hematological malignancies. Idactamab can be used for prepare MEDI7247, a potent and specific ADC, targeting ASCT2 (SLC1A5).

For research use only. We do not sell to patients.

CAS No. : 2245205-37-0

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1 mg USD 400 In-stock
5 mg USD 1040 In-stock
10 mg USD 1665 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Idactamab (INT-001) is an IgG1-κ antibody with in vivo activity across a spectrum of hematological malignancies. Idactamab can be used for prepare MEDI7247, a potent and specific ADC, targeting ASCT2 (SLC1A5)[1][2].

Isotype

Human IgG1 kappa

Recommend Isotype Controls
Species

Human

IC50 & Target

ASCT2 (SLC1A5)[1]

In Vitro

Idactamab inhibits different heme cancer cell lines with IC50 of 0.05-65 ng/mL[1].
ASCT2 (SLC1A5) is a multi-pass, Na+-dependent neutral amino acid transporter that mediates the uptake of amino acids required for tumor growth and progression[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Idactamab improves 3 disseminated Acute Myeloid Leukemia (AML) cell line models: The survival rates of TF1α (high expression of ASCT2), MOLM-13 (low expression of ASCT2) and M.V.411 (high expression of ASCT2) were 0.05 mg/kg, 0.1 mg/kg, and 0.1 mg/kg, respectively[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Idactamab]

Shipping

Shipping with dry ice.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • Human IgG1 kappa
Purity & Documentation

Purity: 95.00%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Idactamab
Cat. No.:
HY-P99654
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