JN403

Cat. No.: HY-111051: FAQs
Data Sheet Handling Instructions

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JN403 is an orally active and selective α7 nicotinic acetylcholine receptor agonist. JN403 can be used in the study of central nervous system disorders.

For research use only. We do not sell to patients.

JN403 Chemical Structure

CAS No. : 942606-12-4

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Description

JN403 is an orally active and selective α7 nicotinic acetylcholine receptor agonist. JN403 can be used in the study of central nervous system disorders^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
GH3	EC₅₀	100 nM Compound: 30, JN403	Agonist activity at human recombinant alpha7 nAChR expressed in human GH3 cells by calcium flux assay Agonist activity at human recombinant alpha7 nAChR expressed in human GH3 cells by calcium flux assay	[PMID: 21919481]

Molecular Weight

292.35

Formula

C₁₆H₂₁FN₂O₂

CAS No.

942606-12-4

SMILES

C[C@@H](C1=C(C=CC=C1)F)OC(N[C@H]2C3CCN(CC3)C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Feuerbach D, et al. The selective nicotinic acetylcholine receptor alpha7 agonist JN403 is active in animal models of cognition, sensory gating, epilepsy and pain. Neuropharmacology. 2009 Jan;56(1):254-63.

JN403 Related Classifications

Neurological Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JN403942606-12-4JN 403JN-403nAChRNicotinic acetylcholine receptorsα7 nicotinic acetylcholine receptornAChR alpha7Inhibitorinhibitorinhibit

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