2. Academic Validation
  3. Antimicrobial activity of isoprenoid-substituted xanthones from Cudrania cochinchinensis against vancomycin-resistant enterococci

Antimicrobial activity of isoprenoid-substituted xanthones from Cudrania cochinchinensis against vancomycin-resistant enterococci

  • Phytomedicine. 2005 Jun;12(6-7):510-3. doi: 10.1016/j.phymed.2004.03.010.
T Fukai 1,  Y Oku,  A J Hou,  M Yonekawa,  S Terada
Affiliations

Affiliation

  • 1 Department of Biophysical Chemistry, School of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan. fukai@phar.toho-u.ac.jp
PMID: 16008130 DOI: 10.1016/j.phymed.2004.03.010
Abstract

Ten Xanthones with one or two isoprenoid groups and a prenylated benzophenone isolated from roots of Cudrania cochinchinensis (Moraceae) were tested for their antimicrobial activities against vancomycin-resistant enterococci (VRE). Among these compounds, gerontoxanthone H exhibited considerable Antibacterial activity against five VRE strains (VanA, VanB and VanC) (MICs = 1.56 microg/ml). Four Xanthones, 1,3,7-trihydroxy-2-prenylxanthone, gerontoxanthone I, alvaxanthone and isoalvaxanthone, showed weaker Antibacterial activity against these VREs (MICs = 3.13-6.25 microg/ml). .

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