2. Academic Validation
  3. Neoclerodane diterpenoids from Scutellaria barbata with cytotoxic activities

Neoclerodane diterpenoids from Scutellaria barbata with cytotoxic activities

  • Nat Prod Res. 2020 May;34(10):1345-1351. doi: 10.1080/14786419.2018.1514399.
Maolin Wang 1,  Yayun Chen 1,  Peng Hu 1,  Junyang Ji 1,  Xiang Li 1 2,  Jianwei Chen 1 3
Affiliations

Affiliations

  • 1 College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
  • 2 Jiangsu Key Laboratory for Chinese Material Medica Processing, Nanjing, China.
  • 3 Jiangsu Key Laboratory for TCM Formulae Research, Nanjing, China.
PMID: 30449170 DOI: 10.1080/14786419.2018.1514399
Abstract

Two new neoclerodane Diterpenoids, barbatin F (1), barbatin G (2) together with four known compounds, scutebata A (3), scutebata B (4), scutebata C (5) and scutebata P (6) were isolated from the whole plant of Scutellaria barbata D.Don. Their structures were elucidated on the basis of spectroscopic studies. In vitro cytotoxicity of selected compounds against Cancer cell lines LoVo, SMMC-7721, HCT-116, and MCF-7 were evaluated, compound 1 and 2 showed weak cytotoxic activities against HCT-116 colon Cancer cell lines with IC50 value of 44.3, 32.3 μM, respectively, while compound 3 and 4 exhibited moderate cytotoxic activities against four tested human Cancer cell lines with IC50 values of 5.31～28.5 μM.

Keywords

Scutellaria barbata; barbatin F-G; cytotoxicity activities; neoclerodane diterpenoids.

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